Interpreting ECG – Echocardiography Principles

An ECG is a ‘snapshot’ of the electrical activity of the heart presented on a graph. When interpreting ECG one can note the heart rate and rhythm, normal/abnormal conduction of both the atria or ventricles, structural changes within the heart such as atrial or ventricular enlargement, as well as an indication of a past Myocardial Infarction.

ECG Principles

The ECG’s value is magnified when recorded during a stress test eg. when the patient is running on a treadmill, or when recorded for a long period of time as in with a Holter.

The pumping action of the heart:

  1. DEPOLARISATION – is initiated by an electrical activation of the myocardium
  2. AUTOMATICITY – causes heart action
  3. EXCITABILITY – responds to the electrical impulse
  4. CONDUCTIVITY – conducts an electrical impulse
  5. CONTRACTILITY – initiates contraction

Repolarisation in an ECG acts as an indication for diagnosis of ischaemia, myocardial stretch, pharmacological effects, electrolyte imbalance, and congenital ionic diseases able to cause a sudden cardiac arrest and imminent death.

interpreting ECG
Motor Unit Action Potential showing Depolarization, Repolarization and Resting Potential – Retrieved from https://www.researchgate.net/figure/Motor-Unit-Action-Potential-showing-Depolarization-Repolarization-and-Resting-Potential_fig2_340126449 on 8th January 2023

In both depolarisation and repolarisation, cardiac myocytes act like electric generators that cause electric currents to flow out into the body and back again into the heart. This produces various electrical potentials on the body’s surface, which are then recorded and represented on an ECG.

The ECG graph is usually set up at a speed of 25mm/s:

  • 1 small square = 0.04 sec
  • 1 large square = 0.2 sec
  • 5 large squares = 1 sec
  • 15 large squares = 3 sec
interpreting ECG
Retrieved from https://www.practicalclinicalskills.com/ekg-course-contents?courseid=301 on 8th January 2023

Each ECG lead used represents the heart from a different point of view on an ECG strip. The horizontal base line recorded is referred to as the iso-electric line, and a deflection from it signals electrical activity of the heart.

A normal ECG strip features the following:

  • P Wave = electrical activity within the atrial chamber
  • QRS Complex = ventricular depolarisation
  • T Wave = ventricular repolarisation

The heart’s conductive system functions through the:

  • SA Node (Sinus Node a.k.a. sino-atrial node) – The pacemaker of the heart, firing about 60-100 times per minute;
  • AV Node (Atrio-Ventricular Junction) – Fires at a rate of 40-60 times per minute. The AV node takes charge whenever the SA node experiences impulse issues;
  • AV Bundle (Bundle of His), Left Bundle and Right Bundle Branches, and the Purkinje Fibres – Fire at 20-40 times per minute if both the AV and the SA node experience impulse issues.

Interpreting ECG

Heart Rate

  • The Rule of 300: when the rhythm is regular = 300 / (number of boxes between R to R wave)
  • Six Second Method: when the rhythm is irregular = number of R waves per 6 seconds X 10

ECG Recording

Limb Connection Points – Retrieved from https://www.pngegg.com/en/search?q=ecg+Monitor on 8th January 2023
Accessed from https://slideplayer.com/slide/10943937/ on 24th January 2021

Deflections

The direction of the electrical current determines the upward or downward deflection of an ECG waveform.

Major deflections include:

  • P Wave – atrial depolarisation
  • QRS Complex – ventricular depolarisation
  • T Wave – ventricular repolarisation
Retrieved from https://ijdr.in/article.asp?issn=0970-9290;year=2014;volume=25;issue=3;spage=386;epage=389;aulast=Anoop;type=3 on 8th January 2023
Retrieved from https://aneskey.com/ecg-basics/ on 8th January 2023

P Wave should be small, rounded, and positive, visible through leads I, II, aVF, and V2-V6, with an amplitude of 0.5-2.5mm and duration of <120ms; there should be only 1 P Wave preceding the QRS Complex.

QRS Normal Interval should be less than 3 small squares on the ECG graph.

ST Segment is normally isoelectric and gently upsloping.

interpreting ECG
Retrieved from https://www.aclsmedicaltraining.com/basics-of-ecg/ on 8th January 2023

QT Prolonged could be indicating Hypokalaemia, Hypocalcaemia, Bradycardia, Drugs, issues with the CNS, Left Ventricular Hypertrophy and Pericarditis.

ST Elevation could be indicating MI or Myocardial Injury, Coronary Vasospasm or Pericarditis.

ST Depression could be indicating Ischaemia, Digitalis Glycocides use (eg. Digoxin), block in the left or right Bundle Branch, or left or right ventricular hypertrophy. ST Depression is a sign of a narrowed blood vessel.

interpreting ECG
Accessed from https://www.pinterest.com/pin/428967933232415341/ on 24th January 2021
interpreting ECG
Retrieved from https://www.cvphysiology.com/CAD/CAD012 on 8th January 2023
interpreting ECG
Retrieved from https://www.cvphysiology.com/CAD/CAD012 on 8th January 2023
interpreting ECG
Retrieved from https://www.washingtonhra.com/arrhythmias/long-qt-syndrome.php on 8th January 2023

NOTE: Some drugs such as antibiotics, anti-psychotic and anti-arrhythmic drugs, prolong depolarisation and repolarisation time.


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Electrical Activity of the Heart

Cardiac muscle cells contract spontaneously, independently, regularly and continuously. Autorhythmic fibres generate action potentials that trigger heart contractions repeatedly, acting as the natural pacemaker of the heart throughout the electrical activity of the heart.

SA Node a.k.a. Sinoatrial Node is the pacemaker of the heart, exactly where cardiac excitation begins. It fires 60-100 electrical impulses per minute (approx. one every 0.8 secs). The SA Node cells DEPOLARISE repeatedly to threshold spontaneously; SPONTANEOUS DEPOLARISATION = PACEMAKER POTENTIAL.

AV Node a.k.a. gatekeeper of the heart acts as an electrical gateway to the ventricles. It fires 40-60 electrical impulses per minute (approx. one every 0.5 secs), evidently having slowed down due to having thinner myocytes with fewer gap junctions over which signals are transmitted. This delay allows the ventricles to fill up with blood before contracting.

The Bundle of His a.k.a. AV Bundle is where action potentials can conduct from the atria to the ventricles, entering both the right and left bundle branches.

Here the Purkinje Fibres conduct the action potential from the apex of the heart up to the rest of they ventricular myocardium, causing the ventricles to contract at the fastest speed of the whole conduction system (4m/s), pushing blood towards the semilunar valves.

Ventricular Myocyte Action Potential

Cardiac myocytes have a stable resting membrane potential of -90mV, depolarising only when stimulated. Ventricular Myocytes’ action potential has 3 phases:

DEPOLARIZATION – a stimulus opens voltage-gated Na+ channels, causing depolarisation as they enter the cells. The threshold voltage opens additional Na+ channels triggering a positive feedback cycle, peaking at almost +30mV. In response the Na+ channels close abruptly, causing the rising phase of the action potential to be very short.

PLATEAU – here is where depolarisation is maintained while the myocytes contract. Voltage-gated slow Ca2+ channels open up allowing small amounts of Ca2+ ions from within the ECF to enter the myocytes. With the binding action of Ca2+ ions to the ligand-gated Ca2+ channels on the sarcoplasmic reticulum, more channels open allowing more Ca2+ ions into the cytoplasm, which then bind to troponin, causing the ventricular myocyte to contract by the stimulus. Finally Ca2+ channels close and K+ channels reopen, causing K+ ions to difuse out of the cell and the Ca2+ ions to return to the ECF.

REPOLARIZATION – The negative resting membrane potential is now restored to -90mV.

Baroreceptors in the Cardiovascular Centre

Baroreceptors are found in the aorta and the internal carotid arteries.

Increase in HR = Increase in CO = Increase in BP = Baroreceptors sense changes & signal to the cardiac centre = cardiac centre Decreases HR.

Decrease in HR = Decrease in CO = Decrease in BP = Baroreceptors sense changes & signal to the cardiac centre = cardiac centre Increases HR & re-stabilises CO & BP.

Chemoreceptors in the Cardiovascular Centre

Chemoreceptors are found in the aortic arch, carotid arteries and the medulla oblongata. These are sensitive to blood pH, Carbon Dioxide and Oxygen.

Chemoreceptors can sense Hypercapnia and Acidosis, which then stimulate the cardiac centre, increasing the HR and restores perfusion of the tissues. Accumulated Carbon Dioxide is then removed.

In response to Hypoxaemia, chemoreceptors lead to a slowing down of the HR.

Below you can find a collection of videos that can help provide a more visual approach to the electrical activity of the heart.

Electrical Activity of the Heart

Ventricular Myocyte Action Potential

Regulation of the Heart Activity Through the ans (autonomic nervous system)

Heart Activity Regulation

role of the cardiovascular centre

baroreceptor reflex

baroreceptor reflex animation

baroreceptors and blood pressure

chemoreceptors

Special thanks to the creators of the featured videos on this post, specifically Youtube Channels Registered Nurse RN, Khan Academy Medicine, DrBruce Forciea, PhysioPathoPharmaco, Khan Academy and Alila Medical Media.

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