Metabolic Syndrome and Obesity

obesity and metabolic syndrome
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Obesity is a disease which involves excessive body fat that increases the risk of additional diseases and health issues, such as cardiovascular disease, diabetes, hypertension, and cancer. Metabolic syndrome is closely linked to obesity and inactivity, as well as insulin resistance.

Retrieved from https://twitter.com/gainalliance/status/854273300389916672?lang=bn on 28th March 2022

Obesity

Obesity is “a chronic relapsing progressive disease progress” (Bray et al., 2017). It is determined by the following factors:

  1. Energy Balance
  2. Obesogenic Environment
  3. Nature VS Nurture

eNERGY BALANCE

Energy In (dietary intake) VS Energy Out (physical activity)

Obesogenic Environment

An environment that promotes weight gain and is not conducive to weight loss.

Nature vs Nurture

Genes affect the metabolic rate, fuel use, brain chemistry, and body shape. Over-eating is learned earlier on in childhood eg. encouraging child to eat whatever is on the plate. Environmental factors add to weight gain influences. Social status affects weight status eg. poverty may lead to unhealthy food choices.

Nutrition Assessment of Obesity

Obesity is characterised by excessive body fat: women with >35% body fat and men with >25% body fat. Excessive body fat puts the individual at increased risk for health problems. Body fat is calculated by measuring skin folds using calipers.

BMI calculation = weight (kg) / height (m2). BMI should ideally be between 18.5 and 24.9kg/m2

Retrieved from https://bjcardio.co.uk/2014/11/obesity-module-1-management-in-primary-care/4/ on 28th March 2022
Retrieved from https://www.researchgate.net/publication/346569912_Obesity_Weight_Loss_and_Cardiovascular_Risk/figures?lo=1&utm_source=google&utm_medium=organic on 28th March 2022

Obesity Health Risks

(Adapted from Bray GA. Gray DS, Obesity, part 1: Pathogenesis. West J Med 149:429, 1988; and Lew EA, Garfinkle L; Variations in mortality by weight among 750,000 men and women. J Clin Epidemiol 32:563, 1979.) Retrieved from https://slideplayer.com/slide/5330508/ on 28th March 2022

Android vs Gynoid Body Fat Distribution

ANDROID

  • obesity centered in the upper-body area – apple shape
  • abdominal fat is released into the liver
  • associated with cardiovascular disease, hypertension and type 2 diabetes
  • related hormone at play – testosterone

GYNOID

  • obesity centered in the lower-body area – pear shape
  • not as risky as android
  • related hormones at play – estrogen and progesterone
Retrieved from https://edu.glogster.com/glog/android-and-gynoid-body-types/2b8qtfg5144 on 28th March 2022
Retrieved from http://www.myhealthywaist.org/index.php?id=56&tx_nurebook_pi1[page]=9&cHash=644d9e5b11 on 28th March 2022

Health Problems Associated with Obesity

  • cardiovascular disease
  • hypertension
  • type 2 diabetes
  • pulmonary disease
  • cancer of the breast,colon, pancreas and gallbladder
  • sleep apnea
  • gallstones
  • bone/joint disorders
  • infertility
  • difficult delivery following pregnancy
  • increased surgical risk
  • reduced agility
  • poor quality of life
  • early death
Retrieved from https://slidetodoc.com/obesity-pathophysiology-risk-assessment-and-prevalence-obesity-excessive/ on 29th March 2022
In women, the incidence of coronary heart disease increased with increasing body mass index levels for both age groups. Among women older than 50 years, the heaviest group experienced 292 incidents of coronary heart disease compared with 223 in the BMI group < 25. In women younger than 50 years of age, the group of 30+ BMI experienced 179 incidents compared with only 76 in the < 25 BMI category. BMI Levels. Adapted from Hubert HB et al. Circulation 1983;67: Metropolitan Relative Weight of 110 is a BMI of approximately 25. Retrieved from https://slideplayer.com/slide/5330508/ on 29th March 2022
Obesity as an independent risk factor for cardiovascular disease was reexamined by Helen Hubert in the 5,209 men and women of the original Framingham cohort. Observations of disease occurrence over the 26 years indicate that obesity was an independent predictor of CVD, particularly among the younger members of the cohort and in women more than men. This study also showed that weight gain after the young adult years conveyed an increased risk of CVD in both sexes that could not be attributed to the initial weight or the levels of the risk factors that may have resulted from the weight gain. This slide shows the increasing incidence of coronary heart disease with increasing body mass index levels for both age groups of men. However, the gradient of risk was steeper among the younger men and women (< 50 years) . Among men younger than 50 years, the heaviest group experienced twice the risk of coronary disease compared with the leanest group. BMI Levels. Retrieved from https://slideplayer.com/slide/12116399/ on 29th March 2022

Weight Loss Benefits & Guidelines

Metabolic Syndrome and Obesity
Retrieved from https://community.jennycraig.com/healthy-habits-blog/live-life/10-ways-losing-5-10-of-your-body-weight-may-benefit-your-health/ on 29th March 2022

Adult Weight Loss…

  • total energy intake should be less than energy expenditure
  • consider diets with 600kcal/day deficit
  • consider low-fat diets alongside expert support and follow-ups for sustainable weight loss
  • keep in mind that low-calorie diets may not provide all nutritional requirements
  • include behaviour change strategies using a biopsychosocial approach and history in relation to past diet experiences as well as comorbidities
Metabolic Syndrome and Obesity
Retrieved from https://www.nice.org.uk/guidance/cg189/chapter/1-recommendations on 29th March 2022

Metabolic Syndrome

Metabolic Syndrome and Obesity
Retrieved from https://pucketteintegrativehealthcare.com/what-is-syndrome-x/ on 1st April 2022

Metabolic syndrome is a worldwide growing epidemic, affecting about 1 of every 4 or 5 adults in every country. Its incidence increases with age.

The term Metabolic Syndrome refers to a group of risk factors which increase the risk for cardiovascular disease, diabetes, stroke, and other health-related problems.

Metabolic Syndrome Risk Factors

  • hyperglycaemia
  • hypertension
  • abdominal obesity a.k.a. android obesity
  • low HDL cholesterol level
  • high triglyceride level (including individuals on treatment for high triglyceride level)
Metabolic Syndrome and Obesity
Retrieved from https://www.researchgate.net/publication/297600439_A_clinical_perspective_of_obesity_metabolic_syndrome_and_cardiovascular_disease/figures?lo=1 on 1st April 2022

WHO Recommendations

Metabolic Syndrome and Obesity
Retrieved from https://adamvirgile.com/2021/01/19/world-health-organization-2020-guidelines-n-physical-activity-and-sedentary-behaviour/ on 1st April 2022

Insulin Resistance

While a third of all individuals with Metabolic Syndrome have normal insulin sensitivity, the two are still associated with each other. Insulin resistance features high plasma insulin concentration which fails to suppress plasma glucose as normally happens. Contributing factors include unresponsiveness to insulin at a cellular level due to receptor-based mechanisms.

Hypertension

Insulin resistance and hyperinsulinaemia may cause hypertension due to an increase in catecholamine activity, as happens with increased insulin concentration through insulin-mediated renal tubular reabsorption of sodium. Weight loss helps in improving both hypertension and hyperinsulinaemia.

Dyslipidaemia

High trygliceride and low HDL cholesterol levels are key factors for metabolic syndrome, both commonly leading to cardiovascular disease. The term dyslipidemia refers to an increase in plasma cholesterol, triglycerides, both, or low HDL cholesterol level which leads to atherosclerosis development.

Preventing or Reversing Metabolic Syndrome

Reference

Bray, G.A., Kim, K.K., & Wilding, J.P.H. (2017). Obesity: a chronic relapsing progressive disease process. A position statement of the World Obesity Federation. Obesity Reviews, 18: 715-723.


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Claire

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Author: Claire

Claire Galea is a mum of three currently in her final year following a Degree in Nursing at the Faculty of Health Sciences, University of Malta, as a mature student. Claire is keen about public education on health-related subjects as well as holistic patient-centered care. She is also passionate about spreading awareness on the negative effects that domestic abuse leaves on its victims’ mental, emotional, social and physical wellbeing. Claire aspires to continue studying following completion of her Nursing Degree, because she truly believes in lifelong education.