Diuretics – Anti-Hypertensives in Cardiovascular Pharmacology

Here you can find videos featuring Diuretics through a visual approach to anti-hypertensive drugs for Cardiovascular Pharmacology use

Cardiovascular pharmacology deals with the study of the effects of drugs upon the heart or circulatory system. Cardiovascular medicines help to prevent and treat cardiovascular disease, slow the progression of it as well as treat its symptoms whilst providing a better quality of life and increasing life expectancy.

Types of Cardiovascular Drugs include:

  • Anti-Hypertensive Drugs
  • Anti-Angina Drugs
  • Anti-Arrhythmic Drugs
  • Anti-Coagulants
  • Anti-Hyperlipidaemic Drugs

Anti-Hypertensive Drugs are further sub-divided into 4 categories, namely:

Renin-Angiotensin Aldosterone Inhibitors

Adrenergic System Inhibitors

Diuretics

Direct Vasodilators

Below you can find a collection of videos that can help provide a more visual approach to cardiovascular pharmacology, specifically on the Anti-Hypertensive DrugsDiuretics

Diuretics: Promote the production of urine, thus increasing urine volume and the excretion of water from the body.

Before starting patient on diuretics, take baseline data of fluid and electrolyte disturbances, hepatorenal diseases, glucose tolerance abnormalities; Assess skin for oedema and skin tugor status; Assess cardiopulmonary status (blood pressure, pulse, heart and lung sounds); Measure body weight to monitor fluid loss or retention.

Monitor intake and output of voiding; monitor lab tests especially K+, Ca+ uric acid and glucose levels; monitor LFTs and renal function.

ADVERSE EFFECTS: electrolyte imbalance, hyperglycaemia, hyperuricemia, acid base disturbances.

Thiazide Diuretics: Bendroflumethazide, Hydrochlorthiazide, Indapamide

  • Most commonly used diuretic.
  • Milder effect when compared to loop diuretics.
  • Causes lower peripheral vascular resistance as well as the excretion of sodium, water, chloride and potassium.
  • INDICATIONS: pulmonary oedema, forced diuresis.

Loop: Bumetanide, Furosemide

  • Causes greatest possible amount of diuresis.
  • Bumetanide is 40% more potent in producing rapid diuresis.
  • Available in oral, IV and IM formulation.
  • INDICATIONS: hypertension, heart failure, oedema.

Potassium Sparing: Spironolactone, Amiloride.

  • Stops sodium reabsorption by interfering with the sodium potassium pump in the distal convoluted tubule.
  • Used along with Thiazides or Loops when increased diuretic effect is desired.
  • INDICATIONS: ideal for patients with low potassium level (hypokalaemia).

Thiazide Diuretics

Loop Diuretics

Potassium Sparing Diuretics

Special thanks to the creator of the featured videos on this post, specifically Youtube Channel Registered Nurse RN

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