Common Kidney Diseases

In normal renal physiology, the kidneys remove waste and excess water from the body and release hormones such as renin (which regulates blood pressure), erythropoietin (which stimulates red blood cell production), and vitamin D (which promotes normal bone structure). However, when kidney disease is involved, renal function becomes compromised and waste products and toxic materials start to accumulate rather than get excreted. This may cause permanent irreversible damage to the body’s cells, tissues, and organs. In this blogpost we are going to go through the most common kidney diseases.

Common Kidney Diseases

  • Polycystic Kidney Disease
  • Hypertensive Nephrosclerosis
  • Glomerulonephritis / Glomeruloscleroisis
  • Urinary Tract Infections
  • Kidney Stones
  • Diabetic Kidney Disease
  • Analgesic Nephropathy

Polycystic Kidney Disease

common kidney diseases
Retrieved from https://medicaldialogues.in/nephrology/news/melatonin-is-effective-against-polycystic-kidney-disease-find-researchers-73960 on 24th December 2021

One of the most common kidney diseases is polycystic kidney disease, which is acquired genetically. In polycystic kidney disease, fluid-filled cysts develop within the kidneys. These cysts replace normal kidney tissue, leading to end-stage renal disease.

Polycystic Kidney Disease can be either DOMINANT or RECESSIVE. In the Dominant form, a parent who has the genetic disease passes it to the child (50% chance).

Signs & Symptoms

  • dull pain at the side of the abdomen and the back
  • upper abdominal discomfort
  • frequent UTIs
  • haematuria (blood in the urine)
  • hypertension

Treatment

  1. control hypertension
  2. treat UTIs with antibiotics
  3. maintain kidney health if diagnosed with chronic kidney disease
  4. provide dialysis or opt for kidney transplantation if diagnosed with end-stage renal disease
  5. administer analgesics for pain relief or opt for the shrinking or resection of the cysts through surgery

Hypertensive Nephrosclerosis

Hypertensive Nephrosclerosis is progressive kidney damage resulting from untreated longstanding hypertension due to blood vessel thickening.

Signs & Symptoms

  • headaches
  • neck discomfort
  • nausea
  • vomiting
  • easily tired
  • proteinuria (protein in the urine)

Treatment

  1. encourage regular exercise
  2. encourage decrease in dietary salt (maximum 2g daily)
  3. administer hypertensives to control hypertension

Glomerulonephritis & Glomerulosclerosis

Glomerulonephritis is the inflammation of the glomeruli (where filtration takes place) in the kidneys. The onset of glomerulonephritis can be either chronic or acute. It can be caused by IgA nephropathy (inflammation in the kidney tissue), Streptococcus bacteria, and autoimmune disease. Similarly, Glomerulosclerosis is the scarring of the glomeruli in the kidneys.

Signs & Symptoms

  • swelling in the leg/s
  • haematuria
  • proteinuria (produces frothy urine)
  • dark or pink-coloured urine
  • additional signs in relation to comorbidities such as diabetes or autoimmune disease eg. weight loss, skin rash, arthritis…

Treatment

  1. control hypertension
  2. suggest dietary modifications
  3. promote a better lifestyle
  4. administer medication for the reduction of urinary protein
  5. administer medication for inflammation suppression eg. steroids

Urinary Tract Infections (UTI)

Urinary Tract Infections occur when microorganisms attach to the urethra and start multiplying. This is a common occurrence in women. If left untreated, urinary tract infections may result in pyelonephritis – an infection of the kidneys, which can cause permanent kidney damage.

Conditions such as diabetes, use of a urinary catheter, abnormalities of the urinary tract, pregnancy, or obstructed urine flow (due to kidney stones or an enlarged prostate) increase the risk of acquiring a urinary tract infection.

Signs & Symptoms

  • increased frequency of urination
  • increased urgency to urinate
  • painful urination
  • pain in the lower abdomen
  • hot foul-smelling urine
  • nausea
  • vomiting
  • haematuria
  • fever

Treatment

  1. encourage increased fluid intake
  2. administer antibiotics to treat infection

Kidney Stones

Kidney stones a.k.a. renal calculi, nephrolithiasis or urolithiasis, are hard deposits of minerals and salts which form within the kidneys. Kidney stones are more common in men between 20-40 years of age.

Signs & Symptoms

  • extreme localised pain
  • painful and/or difficult urination
  • inability to pass urine (if kidney stone obstructs urine outlet completely due to large size)
  • haematuria (due to abrasion caused by the traveling kidney stone)

Treatment

  1. encourage increased water intake (most stones may pass through if not too big)
  2. administer pain relief
  3. administer medication to break down large kidney stones
  4. shockwave therapy
  5. surgery (cystoscopy or open surgery)

Diabetic Kidney Disease

One of the most common kidney diseases is Diabetic Kidney Disease. Diabetes is the most common cause of end-stage renal disease. Diabetes (type 1 and type 2) damage the blood vessels in the kidneys. Additionally, hypertension in diabetics increase the risk for diabetic nephropathy. Diabetic Kidney Disease is most commonly found in chronic and poorly controlled diabetics.

Signs & Symptoms

  • itching
  • lethargy
  • nausea
  • vomiting
  • weight loss
  • nocturia (increased need for urination at night)
  • swelling in the leg/s
  • proteinuria (produces frothy urine)
  • hypertension

Treatment

  1. treat urinary tract infections if present (common occurrence in diabetics)
  2. diabetes control
  3. blood pressure control
  4. encourage low protein diet
  5. administer medication to reduce protein excretion

Analgesic Nephropathy

Long-standing analgesic ingestion is a risk factor for chronic kidney disease. Analgesics such as NSAIDs are commonly used by individuals with conditions that require constant need of pain relief, but such medications increase the risk of end-stage renal disease.

Signs & Symptoms

  • haematuria
  • proteinuria (produces frothy urine)
  • lethargy
  • lack of appetite
  • nausea
  • vomiting
  • swelling of the leg/s

Treatment

  1. reduce as much as possible the use of analgesics
  2. special precaution should be taken by individuals with known kidney disease so as to reduce or possibly eliminate the use of analgesics

Additional Notes…

In patients with kidney disease:

  • teach patient about the importance of fluid restriction – patient should not drink more than 1.5ltr per day
  • teach patient about sodium restriction
  • with regards to nursing documentation, food charting as well as intake & output charting are important

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Benign Prostatic Hyperplasia BPH Nursing Care

Benign Prostatic Hyperplasia is a benign enlargement of the prostate gland. This occurs in around 50% of 50+ males and in over 90% of 80+ males, with a quarter of men requiring some type of treatment by the age of 80. Benign Prostatic Hyperplasia is known as the most common urologic problem encountered in adult males.

Etiology and Pathophysiology of Benign Prostatic Hyperplasia

In ageing males, an imbalance within the endocrine system (gradual decline in hormones during the andropause phase and/or accumulation of dihydroxytestosterone and/or decrease in testosterone resulting in greater estrogen proportion in the blood) may cause Benign Prostatic Hyperlasia.

Risk Factors for Benign Prostatic Hyperplasia

  • ageing
  • obesity
  • sedentary lifestyle
  • alcohol consumption
  • smoking
  • diabetes
  • family history of BPH in first-degree relatives (parent or sibling)

Clinical Manifestations of BPH

Clinical manifestations of Benign Prostatic Hyperplasia are usually gradual in onset, resulting from urinary obstruction by the enlarged prostate. These include:

  • urinary stream caliber and force decrease
  • difficulty in initiating voiding
  • intermittent voiding
  • dribbling a few cc’s of urine following complete urination
  • increased frequency of urination
  • a sense of urination urgency
  • dysuria (burning, tingling, or stinging sensation in the urethra and meatus whilst voiding)
  • pain in the bladder
  • incontinence
  • nocturia (waking up multiple times at night to urinate)

(American Urological Association)

Complications of BPH

  • UTIs
  • residual urine in bladder due to incomplete voiding
  • urinary obstruction that requires a catheter
  • calculi (stones) in the bladder
  • pyelonephritis (kidney/s infection)
  • hydronephrosis (swelling of one or both kidneys) leading to renal failure

Benign Prostatic Hyperplasia Diagnosis

  • patient history
  • physical examination
  • digital rectal examination
  • urinalysis (with culture)
  • serum creatinine
  • post-void residual
  • transrectal ultrasound
  • uroflowmetry
  • cystoscopy
  • rectal prostate ultrasound
  • blood investigations (PSA – prostate-specific antigen; BUN – blood urea nitrogen; creatinine)

Post-Void Residual Bladder

Transrectal Ultrasound (TRUS)

Uroflowmetry

Cystoscopy

BPH Care Aims

  1. Restore bladder function
  2. Relieve symptoms
  3. Prevent and treat BPH complications

NUTRITION: A decreased intake of caffeine, artificial sweeteners, spicy and acidic foods is recommended.

FLUID INTAKE: Individuals with BPH should restrict fluid intake in the evening as this may improve their symptoms.

MEDICATIONS: Ideally individuals with BPH should avoid decongestants and anti-cholinergic drugs.

Benign Prostatic Hyperplasia Treatment

Minimal Invasive Therapies:

Dilation of the urethra (repetitive treatment sessions may be required) and Urethral Stents

Transurethral vaporisation of the prostate

  • reduced bleeding complications
  • short recovery period
  • increased risk for retention

Transurethal Microwave Therapy

Transurethral Needle Ablasion

  • burns designated areas of enlarged prostate
  • ideal for patients with comorbidities

Drug Therapy:

  • Androgen-blocking drugs eg. Finasteride, Dutasteride
  • Alpha-Adrenergic Blockers eg. Doxazosin, Terazosin, Alfuzosin, Tamsulosin, Silodosin (urethral-relaxing drugs)

TransUrethral Resection of the Prostate (TURP)

TURP is a surgical procedure in which obstructive prostate tissue is removed through the use of a resectoscope which is inserted via the urethra.

  • TURP increases quality of life
  • TURP is low risk
  • 80-90% excellent outcome due to improvement in symptoms and urinary flow
Retrieved from https://mgmhealthcare.in/our-specialties/renal-sciences/transurethral-resection-of-the-prostate-turp/ on 7th December 2021
  • TURP is performed under anaesthesia (spinal or general) and requires the patient to be kept for up to 2 days at the hospital.
  • A resectoscope is inserted via the urethra and obstructive prostate tissue is removed.
  • Following the procedure, a 3-way indwelling catheter is inserted into the bladder for haemostasis purposes as well as to facilitate urine drainage.
  • During the first 24 hours following the procedure, the bladder is frequently irrigated so as to prevent obstruction from mucus and blood clots.
  • In TURP there is no external surgical incision done, and so, post-op care requires no surgical wound care.

TURP Preoperative Nursing Care

  1. Educate patient about procedure
  2. Discuss possible complications
  3. Inform about incontinence and urine dribbling for up to a year post-surgery, and the role of Kegel exercises in providing assistance with this problem
  4. Inform patient about retrograde ejaculation (sexual climax reached, but semen enters bladder rather than emerging from penis – not harmful, but may cause infertility)
  5. Gain informed consent
  6. Ensure optimum cardiac, respiratory and circulatory status (decreased risk for complications)
  7. Prophylactic antibiotic treatment is prescribed/initiated
  8. Medical pre-op investigations are carried out (CBC, U&E, MSU – midstream specimen urine, blood group, cross match)
  9. ECG and chest x-ray are performed
  10. Anti-coagulants are stopped as per physician orders
  11. Administer bowel preparation
  12. Glycerin suppositories are administered the night prior to surgery
  13. Patient should be kept NBM for 8 hours pre-op

TURP Postoperative Nursing Care

  1. Monitor vital signs every 15 minutes in the first hour post-surgery, followed by re-monitoring every 4 hours
  2. If patient received epidural anaesthesia, monitor epidural site, monitor extremities every hour for the first 12 hours, monitor intake and output, and keep patient on bed-rest as per anaesthetist’s recommendations
  3. Reassure patient so as to avoid/reduce anxiety
  4. Observe for signs of haemorrhage
  5. Maintain urinary drainage
  6. Maintain urethral catheter patency
  7. Avoid over-distention of bladder (may lead to haemorrhage)
  8. Administer pain medication
  9. Administer anti-cholinergic drugs (drugs that block the action of acetylcholine – reduce bladder spasms)
  10. Maintain bed-rest for 24 hours post-op
  11. Promote comfort through appropriate patient positioning
  12. Administer medication to promote soft-stools so as to avoid straining (which may lead to haemorrhage)
  13. Encourage ambulation as soon as possible to prevent complications such as embolism, thrombosis and pneumonia
  14. Encourage patient to talk about sexual dysfunction fears and promote discussion with partner
  15. Teach methods of urinary control eg. kegel exercises
  16. Encourage foods and fluids if tolerated (unless contraindicated, oral fluids should be encouraged from day 1)
  17. Empty urine bag and measure urine output; document on fluid balance chart
  18. Provide catheter care as necessary; If urine is clear, remove catheter on day 1
  19. Assist patient when taking a shower on day 1 (patient should be able to self-care on day 2)
  20. Promote oral care and assist on day 1 if necessary

Precautions

  • If body temperature exceeds 38.5 degrees celsius, blood and urine culture, CBC and chest x-ray should be performed, followed by paracetamol administration and assistance in bringing fever down.
  • In gross haematuria, IV therapy should be maintained, irrigation rate should be increased, temperature and pulse should be monitored hourly, haemoglobin should be checked, and penile tractions with 1 ltr bag of IV fluid for 20 mins on followed by 20 mins off.
  • If catheter is blocked, try to milk catheter according to unit practice; if unsuccessful, irrigate; if unsuccessful, notify surgeon but DO NOT remove catheter (in the 24 hours following TURP, nurses and junior doctors cannot re-catheterise patient).
  • In the case of failed TWOC (trial without catheter), re-insert catheter.
  • In the case of incontinence post TWOC, encourage use of pads and pants and teach pelvic floor exercises.

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