The Endocrine System – Pancreas Anatomy and Physiology

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The pancreas, which is located in the curve of the duodenum, is a flat organ measuring between 12.5cm-15cm. It is a composite gland – both an exocrine and an endocrine gland: Exocrine acini secrete digestive enzymes into the duodenum, while the Islets of Langerhans help with carbohydrate metabolism.

pancreas anatomy and physiology
Retrieved from https://en.wikipedia.org/wiki/Pancreas on 7th March 2022

Pancreas Blood Supply

The Splenic Artery supplies the pancreas with blood, while venous return is completed through small veins within the Splenic Vein.

pancreas anatomy and physiology
Retrieved from https://epos.myesr.org/posterimage/esr/ecr2014/120564/mediagallery/539242?deliveroriginal=1 on 7th March 2022

Pancreas Nerve Supply

The Autonomic Nervous System (ANS) innervates the pancreas. Parasympathetic Vagal Fibres stimulate exocrine secretion, while Sympathetic Vasoconstrictor Impulses travel through nerves derived from spinal cord segments T6-T10 which pass through blood vessels within the pancreas. This reflects why pancreatic pain frequently radiates these nerve pathways.

pancreas anatomy and physiology
Retrieved from https://clinicalgate.com/thorax-2/ on 7th March 2022

The Endocrine Portion

The Islets of Langerhans contain 4 types of cells:

  1. Alpha Cells – make up 15% of the pancreatic islet cells; secrete Glucagon
  2. Beta Cells – make up 80% of the pancreatic islet cells; secrete Insulin
  3. Delta Cells – make up 5% of the pancreatic islet cells; secrete Somatostatin
  4. F Cells – secrete Pancreatic Polypeptide
Retrieved from https://slideplayer.com/slide/7426531/ on 7th March 2022
  • Glucagon INCREASES blood glucose level
  • Insulin DECREASES blood glucose level
  • Somatostatin INHIBITS insulin and glucagon, acting as a regulator
  • Pancreatic Polypeptide INHIBITS somatostatin secretion, gallbladder contraction, and digestive enzyme secretion (Pancreatic Polypeptide is secreted near the end of the digestive system)

Glucagon

The main function of glucagon is that of increasing blood glucose level. This is carried out through the following process:

  1. Glucagon increases glycogen conversion into glucose within the liver (glycogenolysis) AND increases nutrient (amino acids, glycerol and lactic acid) conversion into glucose within the liver (gluconeogenesis)
  2. Liver releases glucose into the blood, causing an increase in blood sugar level
  3. Blood sugar level controls secretion of glucagon through a negative feedback mechanism

lysis = breaking down of glycogen

neo = new

genesis = production

Secretion of glucagon is STIMULATED by:

  • decreased blood glucose level
  • protein-based foods
  • exercise

Secretion of glucagon is INHIBITED by:

  • somatostatin
  • insulin

Insulin

Islet beta cells produce insulin, which increases protein build-up within the cells. Insulin regulation is controlled by a negative feedback mechanism based on the blood sugar level.

Insulin decreases blood sugar level through the following process:

  1. increases glucose transportation from the blood into the cells
  2. increases glucose conversion into glycogen (glycogenesis)
  3. decreases glycogenolysis and gluconeogenesis
  4. stimulates glucose conversion to fatty acids
  5. stimulates protein synthesis

Secretion of insulin is STIMULATED by:

  • increased blood glucose level
  • acetylcholine (released by parasympathetic vagus nerve fibres)
  • amino acids (arginine and leucine)
  • growth hormone (GH) (which causes increase in blood sugar level)
  • ACTH (adrenocorticotropic hormone) (stimulates glucocorticoids secretion leading to hyperglycaemia, indirectly stimulating insulin release)

Secretion of insulin is INHIBITED by:

  • somatostatin (GIF – growth hormone inhibiting factor)

Insulin production is also AFFECTED by:

  • stomach and intestinal gastrin
  • secretin
  • cholecystokinin
  • gastric inhibitory peptide (GIP)

Insulin vs Glucagon

Somatostatin

Somatostatin is secreted by delta cells in the Islets of Langerhans following an increase in blood glucose, fatty acids, and amino acids due to an ingested meal. Somatostatin travels in the blood, slowing down the absorption of nutrients from the GIT, acting as paracrine secretion, diffusing into tissue fluid targeting nearby cells, and inhibiting both insulin and glucagon release from nearby alpha and beta cells.

Somatostatin secretion is INHIBITED by pancreatic polypeptide.

Pancreatic Polypeptide

Pancreatic Polypeptide inhibits secretion of somatostatin, gallbladder contraction, and secretion of pancreatic digestive enzymes.

Secretion of pacreatic polypeptide is STIMULATED by:

  • protein-containing meals
  • fasting
  • exercise
  • hypoglycaemia

Secretion of pancreatic polypeptide is INHIBITED by:

  • somatostatin
  • hyperglycaemia

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The Endocrine System – Hypothalamus & Pituitary Gland

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The endocrine system is made up of hormone-producing glands within the body which facilitate communication between cells. Glands that make up the endocrine system include the hypothalamus, pituitary gland, and pineal gland, all of which can be found within the brain; the thyroid and parathyroid glands which can be found in the neck; the thymus which is situated between the lungs; the adrenals, which sit on the kidneys; the pancreas, which is found behind the stomach; and the ovaries (women) or testes (men) which are in the pelvic region.

endocrine system hypothalamus and pituitary gland
Retrieved from https://www.blendspace.com/lessons/tv-3ufAxEQI3pQ/group-3-307-313-331-endocrine-system on 3rd March 2022

Within the endocrine system, an endocrine gland or tissue releases an amount of hormone, which amount is determined by the body’s need for that hormone. Through sensing and signalling systems, hormone-producing cells receive information and regulate hormone release amount and duration. Released hormones are carried by the blood to target cells, which contain receptors that bind the hormone, leading to the desired effect. This effect is then recognised by secretory cells through a feedback signal. Once the required hormonal effect is fully accomplished, the hormones are either removed by the liver or the kidneys, or else degraded by the target cells.

Hormonal secretion is regulated by negative feedback control so homeostasis within the body is maintained.

The Hypothalamus

The hypothalamus, which is located below the thalamus, acts as a link between the nervous system and the endocrine system. It receives inputs from various parts of the brain, and sensory signals from internal organs and the retina. Changes are triggered in the hypothalamic activity due to pain, stress, and other emotional factors. The hypothalamus controls the autonomic nervous system and regulates various bodily factors such as temperature, hunger and thirst, sexual behaviour, and defensive reactions.

The Endocrine System - Hypothalamus & Pituitary Gland
Retrieved from https://kids.frontiersin.org/articles/10.3389/frym.2021.534184 on 3rd March 2022

Within the hypothalamus are clusters of specialised neurons – neurosecretory cells, which synthesise the hypothalamic hormones in their cell body. The hormones are transported inside vesicles by axonal transport.

Hypothalamus-Released Hormones

The hypothalamus is an important endocrine gland that produces hormones which, after being released into the blood, travel in the portal veins to a secondary capillary bed found in the anterior lobe of the pituitary, where their effects are produced. Hormones released in this way include:

  • Thyrotropin-releasing hormone (TRH) – related to thyroid gland growth and function
  • Gonadotropin-releasing hormone (GnRH) – related to the reproductive system
  • Growth hormone-releasing hormone (GHRH) – related to growth
  • Corticotropin-releasing hormone (CRH) – related to hormone secretion
  • Somatostatin – related to the growth hormone
  • Dopamine – acts as a neurotransmitter

Hormones which travel in the neurons to the posterior lobe of the pituitary before being released into circulation include:

  • Antidiuretic Hormone (ADH) / Vasopressin – promotes regulation of the amount of water within the body
  • Oxytocin – involved in childbirth and breastfeeding

The Pituitary Gland

The pituitary gland, which measures just about 1.3cm in diameter, is located in the cella turcica of the sphenoid bone. It is attached to the hypothalamus via the infundibulum – a stalklike structure. Pituitary gland hormones regulate body activities. The pituitary gland is divided into two lobes: the anterior lobe and the posterior lobe.

The pituitary gland anterior lobe accounts to around 80% of the pituitary gland. It is involved in growth regulation, metabolism, and reproduction, through its produced hormones. Hormone production happens through stimulation or inhibition by chemical messages originating from the hypothalamus. Thus, hypothalamic hormones act as a link between the nervous system and the endocrine system. They reach the anterior pituitary through the Hypophyseal Portal System.

The pituitary gland posterior lobe is involved in hormone transmission. Hormones originating from neurons within the region of the hypothalamus are secreted directly into peripheral circulation.

The lobes are divided by the pars intermedia – a relatively avascular zone.

The Endocrine System - Hypothalamus & Pituitary Gland
Retrieved from https://www.nature.com/articles/nrdp201692 on 5th March 2022

The 5 Types of Glandular Cells

  1. Somatotroph Cells – produce GH (growth hormone) which is responsible for general body growth
  2. Lactotroph Cells – synthesise PRL (prolactin) which promotes milk production by the mammary glands
  3. Corticolipothroph Cells – synthesise ACTH (adrenocorticotropic hormone) which stimulates hormone secretion, and MSH (melanocyte-stimulating hormone) which is responsible for skin pigmentation
  4. Thyrothroph Cells – produce TSH (thyroid-stimulating hormone), which controls the thyroid gland
  5. Gonadotroph Cells – produce FSH (follicle-stimulating hormone), which stimulates egg and sperm production in the ovaries and testes, and LH (luteinizing hormone), which stimulates other sexual and reproductive activities.
The Endocrine System - Hypothalamus & Pituitary Gland
Retrieved from http://www.pharmacy180.com/article/pituitary-gland-3595/ on 5th March 2022

Growth Hormone (GH)

  • is released through two regulating factors from the hypothalamus, namely GHRF (growth hormone releasing factor) and GHIF (growth hormone inhibiting factor) or Somatostatin
  • causes cells to grow and multiply by increasing the rate at which amino acids enter the cells to be built up into proteins
  • acts on the skeleton and the skeletal muscles firstly by increasing their growth rate, and then maintaining their size when growth is attained
  • increases the rate of protein synthesis a.k.a. protein anabolism
  • promotes fat catabolism by causing cells to change from burning carbohydrates to burning fats to produce energy
  • accelerates rate at which glycogen stored within the liver converts into glucose and releases itself into the blood
  • converts other factors into growth-promoting substances – somatomedins and insulin-like growth factors (IGF), both of which are similar to insulin yet more potent than insulin

Growth Hormone Secretion Stimuli and Inhibition

Retrieved from https://basicmedicalkey.com/normal-endocrine-function/ on 5th March 2022

Prolactin (PRL)

  • requires priming of the mammary glands through oestrogens, progesterone, corticosteroids, growth hormone, thyroxine, and insulin
  • initiates and maintains milk secretion by the mammary glands (amount of milk is determined by oxytocin)
  • has an inhibitory and an excitatory negative control system
  • level rises during pregnancy, falls right after delivery, and rises again during breastfeeding, which is why in the 1st two days following birth, mothers do not produce milk but colostrum

NOTE: women on oral contraceptives may experience lack of milk production due to their hormonal effect.

Melanocyte-Stimulating Hormone (MSH)

  • increases skin pigmentation through the stimulation of melanin granules dispersion in melanocytes
  • secretion is stimulated by the melanocyte-stimulating hormone releasing factor (MRF), or inhibited by the melanocyte-stimulating hormone inhibiting factor (MIF)
  • lack causes the skin to look pallid
  • excess causes the skin to look dark

Thyroid-stimulating factor (TSH)

  • stimulates the synthesis and secretion of hormonal production within the thyroid gland
  • secretion is controlled by the thyrotropin releasing factor (TRF), which is released based on thyroxine blood level, metabolic rate of the body, and other factors through a negative feedback system

Adrenocorticotropic Hormone (ACTH)

  • controls the production and secretion of some adrenal cortex hormones
  • is secreted by the hypothalamic regulating factor called corticotropin releasing factor (CRF), which is released depending on stimuli and hormones through a negative feedback system

Follicle-Stimulating Hormone (FSH)

  • in females initiates the development of an ova every month, and stimulates cells within the ovaries to secrete oestrogens
  • in males stimulates the testes to produce sperm
  • secretion depends on the hypothalamic regulating factor gonadotropin releasing factor (GnRF), which is released in response to oestrogens in females, and to testosterone in males through a negative feedback system

Luteinizing Hormone (LH)

  • along with oestrogens, in females it stimulates the release of an ovum within the ovary, prepares the uterus for the implantation of the fertilised ovum, stimulates the formation of the corpus luteum in the ovary to secrete progesterone, and prepares the mammary glands for milk secretion
  • in males it stimulates the interstitial endocrinocytes in the testes to develop and secrete testosterone
  • secretion is controlled by GnRF, which works through a negative feedback system

Pituitary Gland Posterior Lobe

The posterior lobe of the pituitary gland a.k.a. neurohypophysis, does not synthesise hormones. It releases hormones to the circulation via the posterior hypophyseal veins to be distributed to target cells in other tissues. The cell bodies of the neurosecretory cells produce Oxytocin (OT) and Antidiuretic Hormone (ADH) / Vasopressin.

Oxytocin (OT)

  • is released in high amounts just before birth
  • stimulates contraction of smooth muscle cells in the pregnant uterus
  • stimulates the contractile cells around the mammary gland ducts
  • affects milk ejection
  • works through a positive feedback cycle which is broken following birthing
  • is inhibited by progesterone, but can work in conjunction to oestrogens

Antidiuretic hormone (ADH)

  • affects urine volume; it causes the kidneys to excrete water from fresh urine and return it to the bloodstream, reducing urine volume
  • absence causes an increase in urine output
  • raises blood pressure by constricting arterioles
  • secretion varies based on the body’s needs
  • causes a decrease in sweat
Retrieved from https://slideplayer.com/slide/10623655/ on 6th March 2022

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Suicide Facts and Interventions

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According to the World Health Organisation, suicide is responsible for approximately 2200 deaths per day, which amount to 800,000 deaths per year, or 1 death per 40 seconds (WHO, 2016). In addition, with every successful attempt there are many more attempted suicides. The highest suicide rate can be attributed to the elderly.

4/5ths of individuals who die from suicide have attempted to do it at least once before.

Whilst attempts are three times more often performed by women, men are three times more likely than men to complete it.

Some researchers claim that people with low levels of serotonin are up to ten times more likely to commit suicide than those with normal serotonin levels.

Other researchers claim that 25% of drivers who die in car accidents actually cause them subconsciously, hence the term ‘autocides’, meaning suicides in which individuals crash their cars with the aim of ending their lives.

Psychiatric In-Patient Suicide

Up to 0.4% of suicides take place in a mental health hospital.

Psychiatric inpatients are at particular risk for suicide. Studies show that the inpatients who are most at risk for suicide are those with affective disorders and schizophrenia. Precautions should be taken to reduce the risk of inpatient suicide, and following a suicide, the impact on the individual’s family as well as the other inpatients and staff should be considered.

Level 1 supervision is highly intrusive, but can also be therapeutic. Level 3 supervision is more related to care eg. to prevent falls, not just related to mental health. Based on past observations however, even constant supervision can fail at stopping or avoiding suicide.

suicide
Retrieved from http://blog.needymeds.org/2018/09/12/suicide-prevention-awarness/ on 22nd January 2022
suicide
Retrieved from https://www.facebook.com/NCSBNLearningExt/posts/10157330874509113:0 on 22nd January 2022

Suicide Nursing Assessment

Suicide nursing assessment depth depends on the setting, ability and willingness of the person to provide information about previous and current mental health state, and availability of further information from other healthcare professionals in relation to the same person.

The SAFE-T card pictured below lists key risks and protective factors to be considered while evaluating the person’s suicide risk level. It provides guidance in conducting a comprehensive assessment and triage, risk estimation, and development of treatment plans and interventions based on the person’s mental health state.

SAFE-T assessment
Retrieved from https://store.samhsa.gov/product/SAFE-T-Pocket-Card-Suicide-Assessment-Five-Step-Evaluation-and-Triage-for-Clinicians/sma09-4432 on 22nd January 2022

Suicide enquiry should ideally include questioning about thoughts, plans, behaviours and intent in relation to suicide:

  • Ideation: frequency, intensity and duration
  • Planning: timing, location, lethality, availability, preparation
  • Behaviour: past attempts, rehearsing, self injury
  • Intent: how the person plans to carry out the act, whether the person believes the attempt will be lethal or injuring, and for what reason/s does the person think he should die

NOTE: In Malta, teenagers from 14 years up can ask for treatment even if parents refuse to accept that their child needs treatment, and this is possible thanks to the Mental Health Act.

SAFE-T assessment
Retrieved from https://slideplayer.com/slide/13630104/ on 22nd January 2022

Protective Factors

Protective factors that may help the person during contemplation phase include:

  • ability to cope with stress
  • religious/spiritual beliefs
  • tolerance to frustration
  • responsibilities eg. children and pets
  • positive therapeutic relationships with healthcare professionals who can provide guidance and help
  • social support eg. support groups or family help

Documentation

Documentation should include assessed risk level and the rationale behind the level assigned. It should contain interventions to reduce risk as well as plans for follow-up treatment. Psychotherapy, medication, treatment setting contact with others, and consultation with other past or present healthcare providers should be considered to reduce the possibility of suicide.

Retrieved from https://alea-research.com/suicide-prevention-the-columbia-protocol/ on 22nd January 2022

Are You Contemplating Suicide?

If you landed on this blogpost and you are contemplating suicide, please know that there are people who do care about you and your well-being. Please seek professional support. You can contact Richmond Foundation on 1770, Kellimni.com and Victim Support Malta.


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Psychiatric Emergency VS Mental Health Crisis

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A psychiatric emergency is when an individual experiences an acute disturbance of behaviour, thought or mood. If untreated, a psychiatric emergency may lead the individual to harm self or others. It may happen anywhere in any person, whether diagnosed with a mental health problem or not, and requires intervention by another person (not necessarily by mental health professionals).

A mental health crisis is a situation in which an individual’s actions, feelings, and behaviors can lead them to hurt themselves or others. During a mental health crisis, the individual is at risk of becoming unable to self-care and function in a healthy way within the community.

Psychiatric Emergency Features

A person experiencing a psychiatric emergency exhibits the following 4 behavioural elements:

  1. change and the person’s response towards it
  2. intolerance towards change and towards other persons involved in the situation
  3. reaction of significant others
  4. behavioural change being an instant one

During a psychiatric emergency:

  • the person appears to be extremely agitated, possibly tearful, and highly distressed
  • the person may make extreme demands to others
  • the person may take irrational decisions which seem to be lacking rational judgement
  • the person may put self in danger, the consequences of which are not obvious to the person at the time
  • the person may lack the capacity to relate to the surrounding reality
  • those present during the psychiatric emergency may experience distress and fear, and may act spontaneously in a way that may cause emotional pain or anger following the event

(Ward, 1995)

Psychiatric Emergency Risk Factors

A psychiatric emergency may be triggered by the following psychological responses:

  • fear
  • rejection
  • frustration
  • intrusion
  • inferiority
  • embarassment
  • grief
  • reality conflict
  • psychiatric disturbance

Additionally, a person is more susceptible to experience a psychiatric emergency when:

  • experiencing an acute psychological disturbance
  • experiencing a stressful situation
  • undergoing a detox program
  • being admitted to a psychiatric facility
  • recovering from anaesthesia
  • in an intoxicated state
  • medication is being changed
  • unexpected worsening of physical condition occurs eg. infection
  • witnessing another person’s psychiatric emergency
  • being discharged
  • receiving follow-up community care
  • being cared for in an unfamiliar culture incl. different religious background

Psychiatric Emergency Nursing

Psychiatric emergency nursing may require different types of interventions:

  • verbal intervention
  • physical intervention
  • background management

As a nurse witnessing a PE, aim to:

  1. provide immediate support to help the person regain control over feelings and actions
  2. be flexible by treating the person as an individual with different needs
  3. reduce any possible environmental triggering factors, moving away from the immediate area if required
  4. provide psychiatric first aid to try to reduce the emotional tension being experienced by the person, steering away from the immediate feelings
  5. protect the person experiencing a PE and yourself from physical harm
  6. evaluate the event in both a concurrent and retrospective way to determine the best possible support required by the person
  7. Ask for help or assistance if needed

PE Nursing Care Cycle

Assessment > Intervention > Resolution > Support

Assessment

The person experiencing a PE should be continuously monitored, assessed and re-evaluated. Focus on what the person wants, whether the person (or anyone else) is in danger, what was the behavioural cause, whether any similar situation occurred to the person before and how it was handled, and what it meant for the person if it happened before.

Intervention

Intervention should be provided as mediation between the person experiencing the PE and what is immediately available. Mediate between danger and safety, acting reasonably and quickly in a concise and unambiguous way. Focus on the person’s immediate thoughts and beliefs about self and what is currently causing the issue. Most importantly, act in a calm and confident way.

Safety

  • Inform your colleagues about the situation
  • Do not leave the person alone
  • Stay at arm’s length from a potentially aggressive or an aggressive person
  • Do not let the person stand between you and an exit point
  • Approach slowly
  • Speak slowly and calmly in a ‘matter of fact’ tone, but show that you care
  • Expect that the person may not even reply to your questions
  • Be ‘unshockable’
  • Do not retaliate, do not manhandle, do not belittle, do not respond to personal abuse, and never strike a person even if provoked
  • If grabbed by your clothing, move towards the person rather than away
  • If restraining the person is required, do so in a safe manner for all
  • Always treat the person experiencing a PE with dignity and respect

Resolution

Resolution occurs when the intervention produces a positive effect and the situation becomes no longer critical. In this stage, provide positive reassurance and affirm that it is safe for the person to feel better and relieved. Avoid patronising – keep acting in a kind and calm way without giving away your authority as a nurse. Make sure you reassess the person’s mental state.

Support

During this stage the nurse should re-evaluate the incident’s effects, and encourage the person to reflect on the incident and any possible triggers that could have led to the PE. The nurse should provide emotional support to the person, as well as seek professional support or support from other colleagues.


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Substance Misuse and Addictions

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Substance misuse and addictions can be attributed to many reasons other than just an aim of getting high. Studies show that only 20% of individuals who make use of drugs do so with the primary aim of seeking pleasure. Other reasons for substance misuse and addictions include anxiety, depression, anger, boredom, peer pressure, lack of self confidence and lack of self control.

Substance misuse is more probable where there is availability and peer pressure. It is usually obtained either in an illicit way, or else through the chemist (certain drugs such as codeine), shops (such as solvents) and doctors (such as benzodiazepines).

Terminology related To Substance Misuse and Addictions

Acute Intoxication – a transient condition which follows alcohol or psychoactive substance misuse, resulting in disturbances in the individual’s level of consciousness, cognition, perception, judgment, affect or behavior, or other psycho-physiological functions and responses.

Harmful Use – damage incurred by psychoactive substance misuse in the individual as well as the implicated negative effects on the individual’s family and surrounding society eg. at work, in health, etc.

Physiological Dependence – withdrawal symptoms (eg. urgent need for more) and drug tolerance (needing more than before to experience the same ‘high’ effect).

Psychological Dependence – a sense of urgency to take a substance experienced by a drug-dependent individual, even when knowing of its related consequences; social, occupational and recreational activities are usually neglected by an individual with substance psychological dependence. A person with psychological dependence usually becomes addicted to the whole drug-taking process itself – including making sure they’re not being followed.

Diagnosis

Dependence diagnosis requires 3 of the following to be present for at least a year:

  • increased tolerance to a psychoactive drug
  • physiological withdrawal symptoms exhibited when drug is reduced or stopped
  • a sense of urgency to make use of the drug
  • inability to control substance misuse behaviour
  • neglecting other social, occupational and recreational activities
  • increased amount of time required to obtain and make use of the drug, and to recover from its effects
  • persistent use of drug despite knowing its attributed negative consequences

Experimentation/Recreation Drug Use vs Addiction

A recreational drug user is an individual who has tried the drug, enjoyed its use, may want to re-use it, but does not treat it as a priority.

On the other hand, for a drug addict, the drug becomes the main focus of attention, to a point in which other necessities such as nutrition become unimportant compared to the drug. Addiction is a chronic disorder.

substance misuse and addictions
Retrieved from https://greatoaksrecovery.com/cycle-of-addiction/ on 19th January 2022

The Pharmacology of Drugs

Drug pharmacology can be divided into 2 components: desired effects and unwanted effects. Most drug users do not become addicted, dependent or tolerant to the drug. All drugs cause dopamine to be released within the brain‘s nucleus accumbens, which leads to a pleasurable effect. However, it is motivation that may cause cravings for a drug, and drug-seeking behaviour.

Opiates

Opiates such as heroin (illegal), codeine, morphine, and methadone, are analgesic agents which bind to opioid receptors in the central nervous system, causing pain to be reduced or eliminated.

Opiates create a rush sensation of peace followed by CNS depression. Withdrawal symptoms, such as craving, sweating, yawning, diarrhoea, agitation, goose-flesh, abdominal cramping, and flu-like symptoms, can start developing from as early as 24 hours following dose administration.

substance misuse and addictions
Retrieved from https://addictionblog.org/infographics/heroin-metabolism-in-the-body-how-heroin-affects-the-brain-infographic/ on 20th January 2022
Retrieved from https://www.colleaga.org/tools/clinical-opiate-withdrawal-scale on 20th January 2022

Opiate Replacement Therapy

Methadone is an opiate receptor agonist which is given as a replacement to heroin and other opioids in the case of addiction. Methadone has a longer half-life when compared with heroin, which means that withdrawal symptoms and cravings are reduced without providing the same euphoric effect that heroin provides, giving opioid users a better chance of weaning off or reducing their dose of opioids.

Buprenorphine is an opiate partial agonist. Together with naloxone, which is an antagonist that blocks the euphoric effect related to opioids, buprenorphine is given in tablet form as Suboxone, with the aim of preventing relapse.

An opioid overdose may cause miosis (pinpoint pupils) and respiratory depression (hypoventilation). Naloxone may be required to rapidly reverse opioid overdose by binding to opioid receptors, thus blocking the effects of the other opioids.

Hallucinogens

Hallucinogens – drugs (such as LSD) which cause dilated pupils, increased temperature, vasoconstriction, and hallucinations (distortions in an individual’s perception of reality), can be found in some plants and mushrooms (or their extracts) or can be man-made.

Hallucinogens do not cause physiological dependence, but rare adverse effects may include flashbacks, psychosis, and seizures.

Ecstasy (MDMA in powder form) can induce hyperactivity, and dehydration which can be fatal.

Flakka is a synthetic drug which has been changing in the past. It is very common, yet very dangerous. Psychosis is a common effect of Flakka.

Magic Mushrooms are similar to LSD with regards to effects.

Stimulants

Amphetamines (stimulant drugs eg. speed) cause euphoria, increased concentration, increased energy, mydriasis (pupil dilation), tachycardia, and hyperreflexia, followed by depression, fatigue and headache.

Cocaine can be sniffed, chewed, or taken through the IV route. Its effects are similar to hypomania, and may include visual and tactile hallucinations. Crack cocaine is a highly addictive form of cocaine with a relatively short ‘high’ effect, which may cause persecutory delusions as a withdrawal symptom.

substance misuse and addictions
Retrieved from https://addictionblog.org/infographics/cocaine-metabolism-in-the-body-how-coke-affects-the-brain-infographic/ on 20th January 2022

Cannabis

One of cannabis’s active components is THC, which produces psychological effects such as euphoria, relaxation, an overall well-being sensation, omnipotence and hallucinations. Physiologically, THC causes increased appetite and lowered body temperature.

Cannabis is also associated with depression and schizophrenia. However, to develop schizophrenia, the person using cannabis needs to be at a higher risk of developing it due to factors such as genetic predisposition.

Cannabis may also cause adverse effects such as conjunctival (eye) irritation, decreased sperm production, lung disease, transient psychosis, and apathy. It also causes psychological dependence.

substance misuse and addictions
Retrieved from https://addictionblog.org/infographics/marijuana-metabolism-in-the-body-how-marijuana-affects-the-brain-infographic/ on 20th January 2022

Sedatives and Hypnotics

Benzodiazepines such as Ativan and Valium are commonly used addictive drugs which can cause dependence, withdrawal symptoms, and tolerance. They also carry a risk of seizures and respiratory depression. In the hospital setting, Ativan and Valium are two medications that fall under the Dangerous Drug Act (DDAs).

Solvents

Solvents are typically sniffed with the intention of getting high due to the initial euphoria it causes. This however is followed by drowsiness. Chronic solvent sniffing can lead to weight loss, nausea and vomiting, polyneuropathy (widespread malfunction of peripheral nerves), cognitive impairment, and aplastic anaemia (body ceases to produce new blood cells).

Sniffing solvents may cause a red rush around the mouth and nose – this is a good way of detecting sniffing solvent abuse.

Khat

Khat is commonly used by Somali and Yemeni men. It contains cathionone, which is an amphetamine-like stimulant which causes excitement and euphoria. It is typically consumed through chewing.

Alcohol

Alcohol safe drinking limits are 31 units per week in men, 14 units per week in women, with at least 2 drink-free days per week. Whilst rates of alcohol consumption by women and adolescents are increasing rapidly, younger people are more prone to exceed the stipulated safe limits.

Detecting alcohol abuse is important so as to avoid long-term complications and acute withdrawal effects. A good way to detect alcohol abuse is through screening questionnaires such as FAST and CAGE. CAGE is an ideal questionnaire when alcoholism is suspected. Once detected, an alcoholic individual should be referred for counseling.

Retrieved from https://www.researchgate.net/figure/The-Fast-Alcohol-Screening-Test-FAST_tbl2_260423389 on 20th January 2022
Retrieved from http://www.familyvan.org/module-week-9-substance-use on 20th January 2022

Alcoholism-related terminology

Acute Intoxication – a state in which an individual shows signs of slurred speech, impaired coordination, impaired judgement, and labile affect (inappropriate emotion expression). More severe repercussions include hypoglycaemia, stupor and coma.

Acute Withdrawal – following 1-2 days of abstinence, the individual experiences malaise, nausea, autonomic hyperactivity, tremor, labile mood (uncontrollable crying or laughing at an improper time or situation), insomnia, transient (mostly visual) hallucinations, and seizures. In the worst case scenario, delirium tremens, which is a severe withdrawal symptom related only to alcohol withdrawal, may be experienced. This is characterised by altered mental status and sympathetic overdrive that may progress to cardiovascular collapse. Delirium Tremens carries a 15% mortality rate.

Alcohol Dependence – individual experiences cognitive, behavioural and psychological features with compulsion to drink, preoccupation with alcohol, stereotyped drinking pattern, loss in drinking regulation, and tolerance of alcohol intoxicant effect.

Psychotic Disorders – hallucinations with 2nd person threatening voices and at times pathological or morbid jealousy.

Amnesic Syndrome – Korsakoff’s psychosis: a severe, diencephalic amnesia caused by thiamine deficiency, which is typically noted in alcoholic patients with very poor diets.

Alcohol Abuse Residual Problems – residual depression and dementia.

substance misuse and addictions
Retrieved from https://addictionblog.org/infographics/alcohol-in-the-body-from-drinking-to-elimination-infographic/ on 20th January 2022

Alcohol Abuse Detection and Screening

  1. collect collateral history
  2. look for signs of alcohol disease eg. jaundice, palmar erythema (a skin condition that makes the palms of your hands turn red), gynaecomastia (a common condition that causes boys’ and men’s breasts to swell and become larger than normal), and spider naevi (swollen spider-like blood vessels on the skin often containing a central red spot and deep reddish extensions)
  3. blood tests should be performed to check for macrocytosis (red blood cells that are larger than normal), high gamma-glutamyltransferase (GGT – indicative of liver disease), and high blood alcohol levels

Complications related to alcoholism are usually encountered in the acute setting. These include:

  • gastrointestinal complications
  • haematological complications
  • cardiovascular complications
  • wernicke’s encephalopathy (a life-threatening illness caused by thiamine deficiency, which primarily affects the peripheral and central nervous system)
  • korsakoff’s psychosis
  • peripheral neuropathy
  • cerebellar degeneration (a condition in which cerebellar cells a.k.a. neurons, become damaged and progressively weaken in the cerebellum)
  • erectile dysfunction
  • social complications
  • fetal alcohol syndrome (in pregnancy)

Management

  • motivational interviewing
  • detoxification (possibly including hospitalisation with administration of benzodiazepines and thiamine)
  • learning relapse-prevention strategies
  • referral to self-help groups such as Alcoholics Anonymous
  • administration of Disulfiram, which causes an unpleasant reaction if the individual consumes alcohol, and Acamprosate, which reduces cravings
  • public health measures eg. taxation
substance misuse and addictions
Retrieved from https://www.verywellmind.com/symptoms-of-alcohol-withdrawal-63791 on 20th January 2022

Synthetic Drugs

Synthetic drugs are manufactured to chemically resemble illicit drugs such as cocaine, LSD, MDMA, or methamphetamines, yet can be purchased legally as the manufacturers continuously change the chemical structure to circumvent drug laws. They are usually not detected in urine tests.

Synthetic Cannabinoids, which are commonly used in Malta, are products that mimic the effect of Cannabis in a more potent way. These can be found as solids or oils. Smoking mixtures with added cannabinoids are mostly sold in metal-foil sachets.

Synthetic Cannabinoids cause psychotic symptoms such as extreme anxiety, confusion, paranoia, and hallucinations.

Other synthetic drug names include:

  • Spice – synthetic marijuana / cannabinoids
  • Ecstasy – Molly
  • Bath Salts – contain one or more synthetic chemicals related to cathinone
  • Mephedrone – Meow Meow: commonly found in bath salts
  • Krokodil – cheaper heroin substitute which is a synthetic morphine derivative, commonly used in Russia

NOTE: Psychosis following intoxication can usually be reversed.

The Stages of Change Model

substance misuse and addictions
Retrieved from https://researchcor.com/transtheoretical-model-versus-the-health-belief-model/ on 20th January 2022

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Palliative Nursing Care ~ Pain & Symptom Management and Quality of Life

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What is palliative nursing care?

An approach that improves the quality of life of patients and their families facing the problems associated with life-threatening illness, through the prevention and relief of suffering by means of early identification and impeccable assessment and treatment of pain and other problems, physical, psychosocial and spiritual.

WHO, n.d.

Palliative care is not only available for patients with cancer, but also for patients with no possible recovery, such as patients with end-stage organ failure.

palliative nursing care
Retrieved from https://online.stanford.edu/courses/som-xche0017-palliative-care-always-capstone on 18th January 2022

What is suffering in palliative care?

A multidimensional and dynamic experience of severe stress that occurs when there is a significant threat to the whole person and regulatory processes (which would normally enable adaptation) are insufficient.

Krikorian & Limonero, 2012
palliative nursing care
Retrieved from https://ezgif.com/webp-to-jpg/ezgif-7-4e0210900f.webp on 18th January 2022

Promoting Quality of Life in Palliative Nursing Care

Palliative Nursing Care should aim to provide quality of life, which in other words refers to care in all aspects that palliative patients deem necessary for what they perceive quality of life to be. Such aspects include:

  • emotional needs
  • autonomy
  • healthcare
  • cognitive aspects
  • physical aspects
  • social aspects
  • spiritual aspects
  • preparatory aspects

A primary assessment aims to point out all current issues as well as potential ones. Palliative Nursing Care should include the following domains when it comes to patient assessment:

  • symptoms
  • function
  • interpersonal
  • well-being
  • transcendent

These should be measured through assessment, satisfaction and importance…

palliative nursing care
Retrieved from https://www.semanticscholar.org/paper/Measuring-quality-of-life-for-patients-with-the-of-Byock-Merriman/db4f292e8c6c3d301fdaf2cb4735a9e72e7ca7b0/figure/1 on 18th January 2022

Palliative Nursing Care Systematic Symptom Assessment

A systematic symptom assessment provides a deeper insight when compared to a primary assessment…

palliative nursing care
Retrieved from https://www.sciencedirect.com/science/article/pii/S0885392416312131 on 18th January 2022
palliative nursing care
Retrieved from https://www.tomwademd.net/assessing-your-patients-symptoms-with-the-edmonton-symptom-assessment-scale/ on 18th January 2022
palliative nursing care
Retrieved from https://www.tomwademd.net/assessing-your-patients-symptoms-with-the-edmonton-symptom-assessment-scale/ on 18th January 2022

Symptomatic Pain Management

Symptomatic Pain Management needs to be applied through the nursing process:

  1. ASSESSMENT of the pain
  2. PLANNING pain management
  3. IMPLEMENTATION of medical and non-medical regimen
  4. EVALUATION of applied pain management and its effectiveness
palliative nursing care
Retrieved from https://www.rch.org.au/rchcpg/hospital_clinical_guideline_index/nursing-documentation-principles/ on 18th January 2022

Detailed information about the pain being experienced by the patient, such as location, intensity, quality, effect, and impact (even including the patient’s own descriptive words about experienced pain), leads to an accurate diagnosis and thus, better pain management strategies.

Pain can be classified as either Neuropathic Pain or Nociceptive Pain. Nociceptive Pain is a combination of Somatic Pain and Visceral Pain…

Retrieved from https://edu.glogster.com/glog/acutechronic-pain/2afxqocdhjg?=glogpedia-source on 18th January 2022

Medical Pain Management Strategies

Retrieved from https://www.researchgate.net/figure/New-adaptation-of-the-analgesic-ladder_fig2_258112804 on 18th January 2022

(‘weak opioids’ include Codeine)

Retrieved from https://www.uspharmacist.com/article/special-considerations-for-opioid-use-in-elderly-patients-with-chronic-pain on 18th January 2022

Non-Medical Pain Management Strategies

Non-medical pain management strategies may help in conjunction with medical pain management methods. Helpful methods may include:

  • complementary therapy
  • transcutaneous electrical nerve stimulation (TENS)
  • acupuncture
  • music therapy
  • hypnosis
  • reflexology
  • mind-body therapy
  • art therapy

The Nurse’s Role in Pain Management

  • pain assessment
  • pain management
  • evaluation
  • palliative approach
  • patient education
  • support
  • research
  • patient inclusion in pain management choices through provision of information, enabling informed consent for intervention choices

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Cancer Treatments – Chemotherapy, Radiotherapy, Immunotherapy & More

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Cancer treatments can be offered with various aims, depending on which type of cancer, its location, health status, and at what stage and grading it is discovered.

Cancer spreads through lymph nodes. Thus, when cancer is detected, the nearest lymph nodes are checked for signs of cancer, which, if found, would mean that cancer would have started spreading.

Cancer treatments aims include prevention, cure, control (prolonging survival where cure is unattainable), and palliative care (symptom relief), as well as prophylactic care. Active treatment lasts around 8-12 months, however, in some cases, this may take up to 8-10 years.

Cancer treatments include the following options: surgery, chemotherapy, radiotherapy, hormone therapy, targeted therapy, complimentary therapy, bone marrow transplantation, and supportive therapy. Supportive Therapy aims to treat symptoms of cancer through the use of antiemetics, immunotherapy, etc.

The Nurse’s Role in Cancer Treatments

Patient education is a must with regards to patients with cancer. Providing adequate patient education helps minimise risks during cancer treatment. For example, the nurse should teach the patient to avoid areas which are prone to illness if possible, since a patient undergoing certain cancer treatment is considered to be immunocompromised.

A nurse navigator is assigned to patients with cancer, whose role is to look after a patient throughout the whole treatment journey, as well as provide support for both the patient and other family members.

Cancer and its treatment options impact all domains of a patient’s life.

cancer treatments
Retrieved from https://www.researchgate.net/figure/Proposed-Model-of-Cancer-Treatment-Decision-Making-Roles-of-the-Nurse_fig2_283429018 on 16th January 2022

Patient Perspective of Quality Care in Cancer Treatments

cancer treatments
Retrieved from https://www.semanticscholar.org/paper/Perspectives-of-quality-care-in-cancer-treatment%3A-a-Hess-Pohl/b65299948a68709f74a0ea1ef10a20b9280d59da on 16th January 2022

Cancer Grading and Staging

cancer treatments
Retrieved from https://www.radiation-therapy-review.com/Grading_System.html on 16th January 2022
cancer treatments
Retrieved from https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/CA.2008.0001 on 16th January 2022

Cancer Treatments Responses

cancer treatments
Retrieved from https://askhematologist.com/principles-cancer-therapy/ on 16th January 2022

Surgery

As one of the options for cancer treatments, surgery can be chosen for the following reasons:

  • prevention
  • diagnosis and staging
  • to prevent further growth and spread
  • to reduce the tumour’s size if size becomes a burden to the individual
  • to interfere with the tumour’s growth process
  • to correct defects caused by the tumour
  • to provide pain relief

Factors for consideration prior to surgery include:

  • diagnosis
  • prognosis
  • risks
  • health status
  • impact of recommended surgical procedure

In patients who are predisposed to breast cancer, blood testing is performed to check for BRCA1 and BRCA2 cancer genes. Genetic predisposition carries a risk factor of 10-12% for breast cancer development. If the patient is found positive for BRCA, a prophylactic mastectomy may be recommended.

With regards to pain relief, surgery may be an option too. For example, if a patient has a tumor which is pressing on a neuropathic nerve, removing it surgically would reduce the pain.

Cancer Surgical Treatment Perioperative Nursing Care

  • patient assessment
  • provision of health literacy
  • enabling decision-making and informed consent – patients have a right to refuse treatment
  • providing and/or enabling physical, functional, psychological, social, and spiritual supportive care

Chemotherapy

In chemotherapy, cytotoxic chemicals are used with the aim of eradicating or controlling cancer.

Types of chemotherapy include:

  • cytotoxic therapy
  • systemic treatment
  • neoadjunvant
  • adjuvant
  • chemoradiation
  • first-order kinetics – kills almost all cancer cells through cycle treatments
  • primary and secondary tumour resistance

Chemotherapy can be administered via the following routes:

  • oral
  • intravenous (continuous and bolus)
  • intra-arterial
  • intrapleural
  • intravesical (through the bladder)
  • intrathecal/intraventricular (in the subarachnoid space)
  • intraperitoneal
  • topical
Retrieved from https://bio.libretexts.org/Courses/Lumen_Learning/Book%3A_Biology_for_Non-Majors_I_(Lumen)/07%3A_Cell_Division/7.05%3A_Cell_Cycle_Checkpoints on 16th January 2022
Retrieved from https://doctorlib.info/pharmacology/medical-pharmacology-therapeutics/52.html on 16th January 2022

When selecting the ideal chemotherapy for a patient, the following considerations are taken into account:

  • therapy which offers the maximum therapeutic effect and with what is considered as acceptable toxicity levels
  • assessment of the patient’s physiological and psychosocial status
  • benefits vs toxicity
  • in multi-drug regimen, the aim is to kill as many tumour cells as possible, reduce toxicity, and reduce drug resistance possibility

Prior to chemotherapy administration, the patient should be evaluated so as to determine whether he/she is healthy enough to receive chemotherapy treatment.

Histology results provide accurate tumor grading information.

Chemotherapy Side Effects

Chemotherapy side effects include:

  • myelosuppression – a condition which causes a decrease in bone marrow activity that results in less red blood cells, white blood cells and platelets
  • neutropaenia – an abnormal low concentration of neutrophils (white blood cells) in the blood; may lead to febrile neutropaenia which is characterised by a fever and other signs indicating infection
  • thrombocytopaenia – low blood platelet count
  • anaemia – a deficiency in the number and/or quality of red blood cells
  • alopecia – hair loss
  • oral mucositis – tissue swelling in the mouth
  • fatigue
  • nausea and vomiting
Retrieved from https://www.healthline.com/health/cancer/effects-on-body on 16th January 2022

Nurse’s Role During Chemotherapy Administration

  • patient education – enabling informed consent and establishing reachable goals
  • chemotherapy targets cells that multiply fast, hence why it destroys cancer cells as well as other cells in the body which do the same eg. hair cells (causing alopecia with certain chemotherapies), the lining of the digestive system (causing nausea, vomiting, and diarrhoea)
  • if patient loses hair following chemotherapy, advise patient that hair will regrow once all chemotherapy sessions are completed, even if the texture and colour may be different
  • if patient experiences nausea and vomiting, parameters should be taken so as to check for sepsis; antiemetics may be prescribed so as to reduce side effect; tepid-sponging face and neck may also help the patient feel better; prop up patient so as to avoid aspiration in case of vomiting, as this may cause pneumonia; if patient vomits, encourage oral hygiene since gastric contents would contain chemotherapy, which would lead to the oral mucosa to become damaged – encourage to brush teeth, tongue and gums well with toothpaste, mouthwash, and even rinse throughout the day with a solution made out of 1 tsp baking soda in a cup of water – this balances the acidity in the mouth from gastric content, with the alkaline solution used for rinsing
  • if patient experiences fatigue, encourage to rest, but also encourage bed exercises so as to promote mobility and avoid complications (DVT and pneumonia); reassure patient that once chemotherapy is completed, fatigue lessens; teach patient to identify times during the day in which fatigue is lessened, so as to be able to shower and do other tasks at that time; monitor the patient’s haemoglobin level, as if this is very low, a blood transfusion may be needed
  • chemotherapy administration & safety – safe handling and disposing of chemotherapy for the benefit of all; spillage protocol; extravasation protocol
  • prevention of complications
  • management of side effects
  • ongoing support

NOTE: Chemotherapy is excreted through bodily fluids including urine. Thus patient should aim to use a different bathroom than other family members, or else clean well after use, since if another person comes in contact with the patient’s bodily fluid, there would be a risk of developing cancer and killing cells (chemotherapy is cytotoxic).

Radiotherapy

Radiotherapy a.k.a. radiation therapy is a cancer treatment that uses high doses of radiation to kill cancer cells and shrink tumors through the use of Ionising Radiation. This is done either through External Beam Radiotherapy (EBRT) which works through linear accelerators that produce high energy x-rays that can treat deep tumours, or as Internal Radiotherapy / targeted therapy eg. radioisotope therapy, brachytherapy etc).

Retrieved from https://www.researchgate.net/figure/Basic-diagram-of-a-radiotherapy-treatment-workflow_fig2_329362557 on 17th January 2022

Radiotherapy Side Effects

Radiotherapy side effects are usually related to the area being treated for cancer.

Acute side effects usually show up around 10 days following treatment initiation, with its peak effects showing up around 10 days after the full treatment course.

Late side effects usually develop gradually around 6 months following treatment. These side effects are often permanent.

Side Effects of Radiotherapy for Breast Cancer including Axilla

Acute side effects include skin reactions, pain, and fatigue.

Long-term side effects include Brachial Plexopathy (type of peripheral neuropathy in which damage to the brachial plexus is incurred), Lymphoedema (a condition in which build-up of lymph fluid in the body’s soft tissues causes swelling), Lung Fibrosis (damaged and scarred lung tissue), and Bone Necrosis (death of bone tissue).

Skin Reactions to Radiation Therapy

Retrieved from https://www.researchgate.net/figure/RTOG-Scoring-Criteria-for-Acute-Radiation-Skin-Reactions_tbl3_49780739 on 17th January 2022

If skin reactions to radiation therapy are noted:

  • use a gentle washing technique with mild soap
  • use an electric shaver when shaving
  • avoid exposure of affected area to the sun
  • promote skin hydration using aqueous cream twice daily
  • avoid using deodorants, perfumes and other irritants
  • promote adequate hydration
  • encourage clothing made of natural fibre

Nurse’s Role During Radiotherapy Administration

  • holistic assessment – take into consideration side effect risks
  • patient education
  • aiming to minimise side effects through continuous patient assessment

Hormone Receptors and Hormone Manipulation Therapy

Hormone Manipulation Therapy is a treatment which adds, blocks or removes hormones with the aim of stopping or slowing down cancer cell growth which require hormones to grow.

Side effects of hormone manipulation therapy may include:

  • hot flushes
  • sweating
  • physical changes
  • low libido
  • fatigue
  • nausea

Targeted Therapy

Targeted Therapy refers to the use of drugs or substances which target particular molecules to stop cancer cells from growing and/or spreading. Targeted Therapy doesn’t cause harm to cells other than the ones targeted – cancer cells.

Retrieved from https://www.cell.com/fulltext/S0092-8674(11)00127-9 on 17th January 2022

Immunotherapy

Immunotherapy , which is another type of targeted therapy, stimulates specific components of the immune system and counteracts signals produced by cancer cells that suppress immune responses through checkpoint inhibitors.

Bone Marrow Transplantation

Bone Marrow Transplant (BMT) is a type of cancer (or other diseases) therapy in which cells that are usually found in the bone marrow (eg. stem cells) are filtered and given back to the patient or to another person in need of a bone marrow transplant.

Bone Marrow Transplantation is usually carried out once a patient is in remission. Patient may be sent abroad for this procedure. It is ideal for patients with Leukaemia (the bone marrow is where all blood cells are produced).

Complementary Therapies and Psychological Support for Cancer Patients

  • Homeopathy
  • Detoxification/Antioxidant
  • Nutritional Supplements
  • Diet
  • Acupuncture
  • Aromatherapy
  • Reflexology
  • Therapeutic Massage
  • Reiki / Universal Energy
  • Counseling
  • Psychotherapy
  • Music Therapy
  • Meditation/Relaxation Techniques

NOTE: Homeopathy isn’t recommended when pharmacological therapy for cancer is involved. Similarly, it is important that a cancer patient mentions all medicines and supplements (even vitamins) that are being ingested.


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Preventing Surgical Site Infections SSIs

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Surgical site infections are the second most common types of healthcare associated infections (HAIs). A surgical site is the incision made by the surgeon during a surgical procedure as well as any manipulated surrounding tissue. Surgical site infections may be caused by intrinsic factors (related to the patient) or extrinsic factors (related to the environment or the equipment used). They develop from 2 to 3 days following surgery or during the wound healing period (up to 3 weeks post-surgery).

Pathogenesis of Surgical Site Infections

SSIs develop through an interaction between microorganisms and host, which is also affected by the surgeon and environment. All surgical wounds have microorganisms, including bacteria, but not all develop a clinical infection, since innate host defenses can be very efficient in eliminating contaminants within the surgical site. If however the concentration of microorganisms in the wound is very high, developing a surgical site infection becomes quite possible.

Risk Factors for Surgical Site Infections

Patient-Related Risk Factors:

  • increasing age
  • diabetes
  • obesity
  • smoking
  • immunosuppressants
  • staphylococcus aureus carriage
  • distant infection focus
  • malnutrition

Pre-operative Risk Factors:

  • length of pre-operative stay
  • antibiotic prophylaxis
  • hair removal technique

Operative Risk Factors:

  • wound classification
  • operative technique
  • degree of tissue trauma
  • prolonged duration of surgery
  • traffic intensity in the operating room
  • foreign body presence
Retrieved from https://www.researchgate.net/figure/American-Society-of-Anesthesiologists-classification_tbl1_330901325 on 14th January 2022

Increasing Risk for SSI

intact skin > intact mucous membrane > broken skin or mucous membrane > foreign body implant > foreign body from outside to inside of the body

(foreign body implant eg. prosthetic)

Retrieved from https://www.researchgate.net/figure/Classification-of-surgical-site-infections-according-to-CDC-National-Nosocomial_fig1_44670847 on 14th January 2022

Superficial Incisional SSI:

  • purulent drainage from superficial incision with or without lab confirmation
  • pain OR swelling OR erythema OR heat at incision site (at least one)
  • surgeon deliberately opens incision (unless culture-negative)
Retrieved from https://www.who.int/infection-prevention/tools/surgical/SSI_student-handbook.pdf on 14th January 2022

Deep Incisional SSI:

  • abscess involving deep incision found during radiological exam, direct exam or re-operation
  • deep incision deliberately opened by surgeon when patient has at least one of the following: fever, localised pain, tenderness (unless culture-negative)
  • purulent drainage found during deep incision but not from organ/space component
  • teach patient to monitor for SSIs for 90 days post-operation, and give contact details in case a SSI is suspected
preventing surgical site infections
Retrieved from https://www.who.int/infection-prevention/tools/surgical/SSI_student-handbook.pdf on 14th January 2022

Organ/Space SSI:

Involves organs or spaces other than the surgical incision site such as:

  • Mediastinitis
  • Endocarditis
  • Osteopmyelitis
  • Meningitis
  • Ventriculitis
  • Intra-abdominal

Organ/Space SSI should also include at least one of the following: purulent drainage, organisms isolated from an aseptically obtained culture of fluid or tissue in the organ/space, abscess or other evidence of infection.

preventing surgical site infections
Retrieved from https://www.who.int/infection-prevention/tools/surgical/SSI_student-handbook.pdf on 14th January 2022

Wound Healing

Phases of Wound Healing

preventing surgical site infections
Retrieved from https://journals.rcni.com/nursing-standard/clinical-management-of-nonhealing-wounds-aop-ns.2018.e10829 on 14th January 2022

Surgical Wound Classification

preventing surgical site infections
Retrieved from https://www.semanticscholar.org/paper/The-Impact-of-Preoperative-Hair-Removal-on-Surgical/53d485e036b989f207f9694eebf663be46eae8d8 on 14th January 2022

Post-Discharge Surveillance for Surgical Site Infections

Post-discharge surveillance for surgical site infections are important for early detection of SSIs. Following surgery, the nurse should advise the patient to watch out for signs of SSIs for 30 days post-operation, and give contact details the patient should use in case a SSI is suspected.

Post-discharge SSI surveillance methods include:

  • medical records review
  • admission
  • readmission
  • patient charts for SSI signs and symptoms
  • lab, imaging and other diagnostic tests
  • clinician notes
  • questionaires
  • patient surveys (may be performed through phone or mail)

If an SSI is suspected, or if there is no sign of healing, or if there is unexpected wound healing process deterioration, a specimen should be collected as soon as possible, ideally prior to starting antibiotic treatment.

Organisms Causing SSIs

  1. Staphylococcus aureus
  2. Coagulase-negative staphylococci
  3. Gram negative bacilli
  4. Anaerobes
  5. group B streptococci

WHO Guidelines on Surgical Site Infections

preventing surgical site infections
Retrieved from https://www.theific.org/wp-content/uploads/2017/10/36.pdf on 14th January 2022
preventing surgical site infections
Retrieved from https://www.theific.org/wp-content/uploads/2017/10/36.pdf on 14th January 2022
preventing surgical site infections
Retrieved from https://www.theific.org/wp-content/uploads/2017/10/36.pdf on 14th January 2022

Surgical Handrubbing Technique

Retrieved from https://www.journalofhospitalinfection.com/article/S0195-6701(09)00257-6/references on 14th January 2022
preventing surgical site infections
Retrieved from https://www.journalofhospitalinfection.com/article/S0195-6701(09)00257-6/fulltext on 14th January 2022
preventing surgical site infections
Retrieved from https://www.swissnoso.ch/fileadmin/module/ssi_surveillance/Dokumente_F/7_Presentations/05___E_B-Allegranzi_WHO.pdf on 14th January 2022
preventing surgical site infections
Retrieved from https://www.swissnoso.ch/fileadmin/module/ssi_surveillance/Dokumente_F/7_Presentations/05___E_B-Allegranzi_WHO.pdf on 14th January 2022
preventing surgical site infections
Retrieved from https://www.swissnoso.ch/fileadmin/module/ssi_surveillance/Dokumente_F/7_Presentations/05___E_B-Allegranzi_WHO.pdf on 14th January 2022

Hyperglycaemia and Surgical Site Infections

Hyperglycaemia is associated with an increased risk of developing surgical site infections, especially in the post-operative period. Early post-operative glycaemic control should reduce the incidence of surgical site infections eg. diabetic protocol.

Pre-operative Hair Removal

Unless the presence of hair at the surgery site may interfere with the surgery itself, hair should not be removed. However, if required, hair should be removed with the use of surgical hair clippers with disposable heads. This should be done on the ward at the latest time possible – NEVER at the theatre due to potential contamination of the sterile field. Shavers should NOT be used since these create micro-abrasions in the skin, increasing the of infection.

Following hair removal, patients need to shower with 4% chlorhexidine solution.

Normothermia

Hypothermia increases the risk of developing a SSI since it causes physiological changes, impairs the immune system, causes subcutaneous vasoconstriction, and tissue hypoxia at the incision site. Additionally, hypothermia increases the risk of bleeding, risk of haematoma, and risk of needing a blood transfusion. Thus, pre-operative and intraoperative normothermia should be targeted – ideal temperature is that of 36°C or more.

MRSA and Surgical Site Infections

MRSA carriage increases the risk of developing a SSI. For this reason, patients are screened prior to surgical procedures such as Coronary Artery Bypass Graft, Aortic Valve Replacement, Total Knee Replacement, Total Hip Replacement, cardiac implants, renal catheter insertions, and central venous catheters.

If MRSA is cultivated, decolonisation treatment in the form of washes and mupirocin nasal ointment is required. The patient is screened three times for MSSA (methicillin-susceptible Staphylococcus aureus) prior to the procedure.

Preoperative Washing

Preoperative bathing or showering should aim to reduce skin bacterial load, leading to a reduction in the development of endogenous surgical site infections.

4% Chlorhexidine Solution for MRSA Colonisation: 4% Chlorhexidine solution is a topical antibiotic commonly used as a skin cleanser prior to surgery due to its protective effects against gram-positive and gram-negative organisms, facultative anaerobes, aerobes, and yeast. This is ideal if MRSA colonisation is present.

2% Chlorhexidine Solution for Prolonged/Deep Surgeries: Skin disinfection with 2% Chlorhexidine is enough in the case of prolonged surgery or deep surgery.

Plain Soap for Minor Surgeries: For other minor surgeries, washing with plain soap is enough.

NOTE: Make sure the patient stays warm prior to being operated upon, since this reduces the chance of developing SSIs.

Prophylactic Use of Antibiotic

CHOICE OF ANTIBIOTIC TREATMENT

Antibiotic treatment choice for prophylactic use should be based on the wound contamination level and efficacy against expected pathogens related to the specific surgery being performed.

TIMING

First dose of prophylactic antibiotic should be given 60-120 minutes prior to surgery being performed, as this ensures bactericidal concentration in serum and tissues from incision until closure. Additional doses may be required for longer surgeries.

DURATION

Unnecessary continuation of antibiotic treatment may contribute to the ever-growing problem of antibiotic resistance.

Retrieved from https://www.who.int/docs/default-source/antibiotic-awareness-week/infographic-ssi-sap011118-bis.pdf on 15th January 2022

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Infection Prevention and Control

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Infection prevention and control (IPC) is a practical, evidence-based approach which prevents patients and health workers from being harmed by avoidable infection and as a result of antimicrobial resistance.

No one should catch an infection while receiving health care, yet, these infections can spread through outbreaks and many regular care practices, affecting hundreds of millions of people across the world every year.

World Health Organisation

The Chain of Infection

infection prevention and control
Retrieved from https://activesocialcare.com/handbook/infection-prevention-and-control/the-chain-of-infection on 12th January 2022

A HAI (hospital acquired infection) occurs:

  • up to 48 hours after hospital admission
  • up to 3 days after discharge
  • up to 30 days after an operation

RESERVOIR:

A microorganism lives and multiplies in what we call ‘reservoirs’: humans (eg. chickenpox, hepatitis B, and HIV), animals (eg. rabies, and salmonella), or inanimate objects (eg. tetanus).

INFECTION SOURCE:

This is the source of infection – a specific infection outbreak or an individual infection. An endogenous infection refers to an infection caused by the patient’s own microflora, while an exogenous infection refers to an infection caused through an environmental source. Zoonosis refers to an infection originating from an animal source.

ENTRY PORTALS:

  • respiratory tract eg. pneumonia
  • GI tract eg. Clostridioides difficile or C. difficile
  • genito-urinary tract eg. CAUTI (catheter acquired urinary tract infection)
  • skin breaks (including traumatic and surgical wounds)
  • blood (through needles and catheters)

All patients are at risk of acquiring a MDRO (multi-drug resistant organism)!

TRANSMISSION ROUTES

  • direct and indirect contact
  • air
  • food
  • drink
  • water
  • insects

Direct or indirect contact include transmission via hands, transmission by inanimate objects, transmission by contact with blood, and transmission through sex…

Transmission via Hands:

  • Staphylococcus aureus can be spread by staff, either through spreading their own nasal staph to their patients, or spreading staph from one patient to another.
  • Gram-negative bacteria can be found colonising a patient’s skin, and then transmitted onto staff hands.
  • Enteric Infections such as shigella and rotavirus (commonly found in children) are faecal-oral spreads transmitted via hands in the community and hospital setting.

Transmission via Inanimate Objects a.k.a. Fomites:

This type of transmission happens passively from one inanimate object to another. Objects include surgical instruments as well as more common objects such as pens, stethoscopes, books, suction catheters, bedpans etc.

Transmission via Sexual Contact:

Sexually transmitted diseases (STDs) are considered to be very fragile and so, they do not usually survive on inanimate objects. STDs include syphilis gonorrhoea, chlamydia, HIV, herpes, etc.

Transmission via Blood:

Transmission by contact with infected blood happens through wounds, menses, human bites, blood products, specimens, contaminated needles (including needle-stick injuries), and during traumatic sexual intercourse.

Endemic Hepatitis B is transmitted during birth from the mother to her baby. Other infections which can pass to the foetus during pregnancy includes rubella, cytomegalovirus and syphilis.

Transmission via Air a.k.a. Airborne Transmission

Transmission via air happens through sneezing, coughing and speaking. Small droplets (<0.1mm) evaporate; Solid droplet nuclei may remain airborne…these may be eventually inhaled. Measles, chickenpox and tuberculosis are spread in this way. Large droplets fall to the ground.

Transmission via Food, Drink, and Water:

Transmission of infection via food, drink and water usually happens in enteric infections via faecal-oral spread.

In food poisoning, bacteria multiply in food prior to ingestion, producing enteric toxin (eg. in staph aureus) or multiply and produce toxin in bowel lumen (eg. in cholera and E.coli). Salmonella happens through infection following ingestion of poorly-cooked food. Brucellosis is an infection resulting from drinking unpasteurised contaminated milk. In water-borne cholera, faecal excretion by-carriers contaminate river water which is then consumed downstream.

Transmission via Insects a.k.a Anthropod-borne Infections:

Anthropod-borne infections are transmitted by blood-sucking insects such as mosquitos (malaria). These parasites have the ability to multiply in their hosts.

The Infection Spectrum

Contamination => Colonisation => Critical Colonisation => Infection

Colonisation is the presence of multiplying bacteria with no reaction or symptoms.

Infection is the presence of multiplying bacteria which affects the host’s defenses, causing clinical symptoms.

Bacteria can be transmitted even if no infection is present. This explains why Staphylococcus aureus, which is endemic, can be found outside the hospital, within the community, undetected.

MRSA – Methicillin Resistant Staphylococcus Aureus

MRSA is resistant to common antibiotics such as penicillins and cephalosporins. MRSA can be carried around by healthy individuals without any symptoms for weeks to years.

MRSA in a patient with a low colonisation level may not be detected by culture. Anterior nares specimen testing result in the highest identification rate for MRSA. Gloves should be worn when caring for infected wounds of patients with MRSA.

Patients are screened for MRSA on admission and more importantly before important procedures.

Treatment for MRSA decolonisation:

  • 2% Mupirocin (Bactroban) nasal ointment 3 times per day for 5 days (apply small amount to inner nostrils using tube, press nostrils together and massage for about 1 minute).
  • Daily full body and hair washes with 4% chlorhexidine gluconate.

Isolation and Contact Precautions for Infection Prevention and Control

Isolation and contact precautions should be put in place in the case of current or previous 6 months colonisation or infection with MDRO. Contact precautions notice should be put up on the patient’s door, and related information should be provided for both the patient and relatives.

Contact precautions can be stopped:

  • if the organism is not cultured again
  • in case of 3 consecutive negative MRSA screen cultures

Terminal cleaning of patient’s room must be performed!

Infection Prevention and Control

5 Moments for Hand Hygiene

  1. BEFORE patient contact
  2. BEFORE aseptic task
  3. AFTER body fluid exposure
  4. AFTER patient contact
  5. AFTER leaving patient surrounding
  • Soap & Water mechanically remove microorganisms and soil but DO NOT kill microorganisms; remove transient skin flora, but only limited resident flora.
  • Alcohol Rub DOES NOT mechanically remove microorganisms or soil, but kills microorganisms; kills transient skin flora, but only limited resident flora.
  • Aqueous Antiseptic Solutions mechanically remove and kill microorganisms and soil; remove and kill transient and some resident skin flora.

Standard Precautions for Infection Prevention and Control

Standard precautions should be applied by all staff in all healthcare settings to all patients regardless of diagnosis and infection status all the time.

  1. Good hand hygiene practice
  2. Use waterproof dressings to cover wounds or skin lesions
  3. Use cough etiquette
  4. Do not touch your eyes, nose, mouth or face, or adjust PPEs with contaminated hands or gloves
  5. Limit contact with patient’s items in immediate surrounding area to the minimum
  6. Use recommended PPEs for required tasks anticipating possible risks

Donning PPEs Sequence:

  1. Gown
  2. Mask
  3. Visor
  4. Gloves

Doffing PPEs Sequence:

  1. Gloves
  2. Visor
  3. Gown
  4. Mask

Swabbing Methods

Staphylococcus aureus produces a higher cultivation of bacteria in the nose and throat, thus swabbing methods used for MRSA are the nasal swab or the throat swab. Note however, that MRSA can also be found in other locations within the body, such as in wounds.

Nasal Swab

Throat Swab

Wound Swab

Urine Sampling

Sputum Sampling

Stool Sampling

Blood Cultures

Retrieved from https://studylib.net/doc/8188811/bd-vacutainer%C2%AE-system—st-vincent-s-university-hospital on 13th January 2022

Peripheral Vascular Catheter Care

Retrieved from https://www.facebook.com/641909052635080/photos/visual-infusion-phlebitis-score-detail-has-been-attached-hereindetail-topic-will/1149380728554574/ on 13th January 2022

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Nutrition and Hydration for Older Adults

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Nutrition and hydration for older adults are key elements for better health and good quality of life. Unfortunately, malnutrition is very common in older adults. The older the person, the less nutrients are absorbed by the body from food. Adequate food intake and proper hydration promote quicker recovery and shorter hospitalisation periods, as well as avoidance of hospital readmission, following illness and surgery in older adults.

Nutrition and Hydration for Older Adults
Retrieved from https://www.facebook.com/narayanisfitnactive/posts/new-food-pyramid-for-healthy-diet-narayanis-fit-active-gymwardhaman-nagar-nagpur/689653301412038/ on 9th January 2021
Nutrition and Hydration for Older Adults
Retrieved from https://www.hsph.harvard.edu/nutritionsource/healthy-eating-plate-vs-usda-myplate/ on 9th January 2021

Ideal Meal Plan

An ideal meal plan should include:

  • Breakfast
  • Snack
  • Lunch
  • Snack
  • Dinner

Nutrition for Older Adults

A healthy balanced diet helps maintain physical and mental well-being. Eating less than required may lead to weight-loss, vulnerability to infection, reduced muscle strength, and fatigue. Causes of weight loss may include:

  • reduced appetite
  • cooking difficulties
  • inability to recognise hunger cues
  • inability to ask for food
  • lack or poor coordination skills
  • cognitive impairment
  • physical disabilities
  • sensory disabilities
  • depression
  • medication
  • fatigue
  • dysphagia
  • inability to chew properly
  • lack of physical activity
  • pain (denture problems, sore gums, painful teeth, lack of oral hygiene)

In older adults with late-stage dementia, the nurse should ensure adequate nutrition is being provided, and in some cases, a high-calorie diet may also be appropriate.

An older adult experiencing weight-loss should be referred to a nutritionist or dietitian.

Meal Supplementation for Older Adults

Meal supplement options for older adults include:

  • Snacks
  • Yoghurts
  • Protein Powder (check liver/kidney function prior to administering protein powder)
  • Enteral Feeds (can be administered in between meals or as replacements if needed)

Vitamin supplements can be avoided if the person eats a varied and balanced nutritional diet.

Common Chronic Illnesses in Older Adults

  • Diabetes
  • Hypertension
  • Hyperlipidaemia
  • Renal Disease
  • Cancer
  • Gum Disease
  • Arthritis (certain proteins eg. nuts, legumes, and seeds, deposit fats in joints, which is very helpful for patients with arthritis)
  • Refeeding Syndrome (shifts in fluids and electrolytes resulting from hormonal and metabolic changes which may occur in malnourished individuals receiving enteral or parenteral artificial feeding that may lead to death)

Common Problems in Older Adults

  • anaemia
  • depression
  • overweight / underweight
  • constipation
  • food allergies
  • inability to chew food appropriately
  • dysphagia (problems encountered in swallowing)
  • cooking methods

Assessing Older Adults

Nutrition and hydration in older adults should be assessed:

  • to identify any existing problems
  • to provide help with existing problems
  • to promote safety
  • to improve quality of life
  • to improve current available services
  • to create new / better services

Encouraging Nutrition Intake in Older Adults

  • provide regular snacks or small meals
  • foods with low glycemic index (low GI) are more digestible
  • provide food that the older adult actually likes
  • provide appealing foods for appetite stimulation
  • experiment with different types of food such as smoothies and milkshakes
  • experiment with foods containing strong flavours and sweet flavours
  • find the right time to offer foods based on the individual’s day/night routines
  • provide dessert even if main meal is left unfinished or untouched, as it may be preferred
  • avoid giving cold food – reheat if necessary
  • if the older person finds it difficult to chew or swallow food, try opting for softer-textured foods such as scrambled egg or stewed apple before considering pureed food
  • provide encouragement
  • provide a relaxed friendly atmosphere

The Importance of Hydration for Older Adults

Water is helpful for bloating, oxygen saturation, headaches, circulation, depression, digestion, kidney function, metabolism, and promotes healthy skin. Moreover, the brain requires water to function well. More than 2/3 of the brain is made up of water. With age increase comes a reduction of thirst sensation, which may lead to dehydration.

Older adults with dementia may become easily dehydrated if they are unable to communicate or recognise thirst cues, or if they forget to drink. Dehydration may lead to headaches, confusion, UTIs and constipation, all of which can worsen the symptoms of dementia.

  1. Older adults should be encouraged to drink between 1.5-2.5 liters of fluid on a daily basis.
  2. Older adults may be taught to check their hydration level by observing their urine’s colour and smell.
Retrieved from https://www.pinterest.com/pin/174162710566911662/ on 9th January 2021
Retrieved from https://www.quotemaster.org/water+drinking on 9th January 2021
Retrieved from https://www.continencesupportnow.com/topic/Fluid%20intake on 9th January 2021
Retrieved from https://www.healthworks.my/hydrate/ on 9th January 2021

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