What are the key concepts of critical appraisal? This blogpost features a very good series of critical appraisal training videos published by Cochrane Mental Health on Youtube (full credits can be found at the bottom of this blogpost).
Hierarchy of Evidence
Critical Appraisal Introduction
In this first video, the key concepts of critical appraisal are introduced, and the learning objectives for the series are clearly defined.
Systematic Reviews and Meta Analysis
In this second video, we are introduced to the fundamentals of systematic reviews and the ways in which we can apply the critical appraisal concepts of validity, trustworthiness of results, and value and relevance using the CASP checklist. The full text version of the study by Hay et al (2019) mentioned in this video can be found here.
Randomised Controlled Trials
In this third video, we are introduced to the fundamentals of randomised controlled trials and the ways in which we can apply the critical appraisal concepts of validity, trustworthiness of results, and value and relevance using the CASP checklist. The full text version of the study by Sugg et al (2018) mentioned in this video can be found here.
Cohort Studies Critical Appraisal
In this fourth video, we are introduced to the fundamentals of cohort studies and the ways in which we can apply the critical appraisal concepts of validity, trustworthiness of results, and value and relevance using the CASP checklist. The full text version of the study by Gerhard et al (2015) can be found here.
Case Control Studies
In this fifth video, we are introduced to the fundamentals of case control studies and the ways in which we can apply the critical appraisal concepts of validity, trustworthiness of results, and value and relevance using the CASP checklist. The full text version of the study by Drucker et al (2018) can be found here.
Cross Sectional Studies
In this sixth video, we are introduced to the fundamentals of cross-sectional control studies and the ways in which we can apply the critical appraisal concepts of validity, trustworthiness of results, and value and relevance. The full text version of the study by Boden et al (2010) can be found here.
Diagnostic Studies Critical Appraisal
In this seventh and last video, we are introduced to the fundamentals of diagnostic studies and the ways in which we can apply the critical appraisal concepts of validity, trustworthiness of results, and value and relevance using the CASP checklist. The full text version of the study by Hollis et al (2018) can be found here.
Reference
The above embedded videos are part of a project which was developed to enhance research use and development across two NHS Trusts.
The project founding partners were:
Cochrane Common Mental Disorders
Northumberland, Tyne and Wear NHS Foundation Trust (NTW), UK
Tees, Esk and Wear Valleys NHS Foundation Trust (TEWV), UK
Delivery of the project was supported by the Centre for Reviews and Dissemination at the University of York.
Funding Acknowledgement: The production of the critical appraisal modules was jointly funded by:
Economic and Social Research Council (ESRC), UK – as part of the University of York ESRC Impact Acceleration Account (ES/M500574/1)
Northumberland, Tyne and Wear NHS Foundation Trust (NTW), UK
Tees, Esk and Wear Valleys NHS Foundation Trust (TEWV), UK
University of York, UK
Cochrane Review Group Funding Acknowledgement: The National Institute for Health Research (NIHR) is the largest single funder of the Cochrane Common Mental Disorders Group.
Disclaimer: the views and opinions expressed herein are those of the module authors and do not necessarily reflect those of the ESRC, NIHR, the National Health Service (NHS), the Department of Health and Social Care or the University of York.
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Patients in the critical care setting are more susceptible to Health Care Associated Infections (HCAIs), making infection prevention and control even more crucial within this setting. Some of the most common infection manifestations in the critically ill patient include pneumonia following intubation, bloodstream infections following IV catheterisation, and UTIs following urinary catheterisation.
Susceptibility to HCAIs within the critically ill population can be due to:
altered immunity – due to steroid use, surgery, anaesthesia and age
invasive lines – provide direct entry of bacteria into the patient’s bloodstream
These risks cause an increased morbidity and mortality rate, a longer hospitalisation stay, and subsequently, higher treatment costs.
Antibiotic Use
We are currently witnessing a dramatic increase in infections by multi-drug resistant pathogens, leading to difficult infection management due to the scarcity of available antibiotics. Even more so, within the critical care setting there is an increased risk of patient-to-patient transmission, increased antibiotic use, and critically sick patients.
Infection Prevention and Control in the ICU Setting
General Preventive Techniques
follow the 5 moments of hand hygiene
alcohol hand rub should be the first hand hygiene choice – unless hands are visibly soiled
nails should be kept well trimmed with no gels
reduce jewellery use to just one plain wedding band if necessary
keep patients with MDRO in isolation rooms if possible
allocate equipment to one patient without sharing
screen patients for MDRO, specifically for MRSA, CRE and VRE on admission and at least weekly thereon
promote awareness on ANTT (aseptic non-touch technique) amongst colleagues
ensure disinfection of shared equipment such as monitoring lines, saturation probes, ECG leads, and blood pressure cuffs
promote education on infection prevention and control for staff and cleaners
educate patients’ relatives on infection prevention and control measures
ensure appropriate antibiotic use
ensure terminal cleaning of bed area upon patient discharge
Glove Use
change gloves between procedures on the same patient when performing dirty vs aseptic tasks
change gloves between patients
don gloves immediately before contact with patient body fluid, mucous membranes, or non-intact skin
remove and discard immediately after a procedure and perform hand hygiene so that contamination is not transferred to another patient
Rectal screening for CRE and VRE
insert a charcoal swab approximately 2cn inside the rectum and rotate gently
ensure swab is brown-stained with faeces to ensure a good sample has been taken, as inadequate samples are not processed by the lab
Bathing Patients in Critical Care Setting
as previously mentioned, there is a high prevalence of MDROs in the critical care setting
daily chlorhexidine bathing of patients in the critical care setting is encouraged since chlorhexidine helps reduce the risk of acquiring MDROs
washing the patient’s body with chlorhexidine has been showing effectiveness in the prevention of carriage and possibly bloodstream infections with Gram-positive MDROs (MRSA and VRE)
chlorhexidine washes have shown possible eradication of carriage and infection prevention of Gram-negative MDROs, however, more evidence is required in this regard
Disinfecting Isolation Rooms
isolation rooms should be disinfected on a daily basis
isolation rooms should be cleaned last using yellow cloths, disposable gloves, and chlorine-based disinfectant
terminal cleaning and disinfection of isolation rooms should be done following patient discharge; all surfaces need to be cleaned with detergent; mattresses and pillows should be cleaned with environmental disinfectant wipes; UV-C disinfection should be performed, by which more than 99.9% of C. difficile spores and MRSA are killed in minutes
DISADVANTAGES OF USING CHLORINE-BASED DISINFECTANT:
corrosive
long contact time
employee complaints
The Nurse’s Role in Proper Antibiotic Management
knowledge on antibiotic resistance
knowledge on the most frequently used antibiotics within the critical care setting
knowledge on the disadvantages of using broad spectrum antibiotics – prolonged use increases risk of C. difficile
administer antibiotics at the recommended dosage intervals for optimal effectiveness
administer IV antibiotics safely and effectively, with diligence to dosage, dilution, timing and calculations
administer IV antibiotics to patients with sepsis within 1 hour following diagnosis to increase risk of survival
list reminders for antibiotic review eg. stop date, reason for prescription, change of route, etc
therapeutic monitoring of antibiotic levels eg. Gentamicin, Amikacin and Vancomycin require serum blood level checking for safe and effective treatment; ensure samples are taken at the appropriate time for best results
understand when to withold an antibiotic dose until results are available eg. in the case of Gentamicin
serum blood level samplings should be properly documented in both the patient’s notes and on the lab request form
proper handover on transfer from ICU to another ward
Ventilator Associated Pneumonia (VAP)
Pneumonia is an infection in the lung parenchyma, particularly in the bronchioles and alveoli, which is caused by pathogens such as bacteria, fungi and viruses.
Ventilated Associated Pneumonia (VAP) is pneumonia which develops 48 hours following intubation and initiation of mechanical ventilation. VAP is considered to be the 2nd most common HCAIs but the most serious one, with 25% of these patients with VAP ending up dead.
VAP happens because intubation bypasses all natural defense mechanisms within the tracheo-bronchial tree that protect the lower respiratory tract from infections.
Causative organisms, some of which are often present in the oropharyngeal cavity and the gastrointestinal system, are:
There are 5 defense mechanisms which are bypassed during ventilation:
The Larynx and the Glottis – prevent aspiration of oral content
The Coughing Reflex – helps in the expelling of secretions and aspirated matter from the larger airways
Mucous – helps trap small particles
Cilia – hair-like structures which help move mucous up from the lower respiratory tract towards the larynx to be expelled
Phagocytic Cells – engulf bacteria if or when they manage to reach the alveoli
Aspiration of contaminated fluids and secretions into the lungs can happen in various ways:
colonisation of pathogenic bacteria within the oropharynx or tracheo-bronchial tree
the stomach, through enteral feeding, certain drugs (eg. stress ulcer prophylaxis), and supine patient positioning, may act as a source of pathogens for VAP
inhalation of aerosols through contaminated intubation or nebulisation equipment
Pathological development of pneumonia
aspiration of contaminated fluids or secretions into the lungs
initiation of the inflammatory response
swelling of the mucous membranes of the alveoli and bronchi
pus collects within the alveoli
interference of pus with the gas exchange process
development of pneumonia
Signs & Symptoms of VAP Pneumonia
temperature of >38°C
tachypnoea and/or dyspnoea
purulent sputum (off-white, yellow or green, and opaque)
worsening ABGs – poor SaO2 and increased ventilatory demands
positive sputum and/or blood cultures
leukocytosis >12,000 WBC/mm2
chest x-ray or CT scan with evidence of pneumonia
NOTE: Diagnosing VAP can be difficult!
VAP Risk Factors
length of time in which the patient is exposed to the healthcare environment
predisposing host-related factors such as age, malnutrition etc
choose non-invasive ventilation over invasive ventilation where possible
elevate head of bed 30-45° especially for patients receiving enteral feeding
minimise aspiration of contaminated oropharyngeal and tracheal secretions
suction subglottic secretions
avoid gastric over distention
avoid unplanned extubation
maintain correct ETT cuff pressure (20cm H2O)
provide frequent oral hygiene – suctioning, toothbrushing, and using chlorhexidine mouthwashes
use HME filters rather than heated humidifiers
remove condensate from ventilatory circuits periodically
extubate as soon as possible
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One of the most common measures required in neonatal and paediatric intensive care nursing is respiratory support. Such assistance for the neonate or paediatric patient may include the use of nasal prongs, high flow nasal cannulae, non-invasive ventilation, or invasive ventilation. Invasive ventilation should be left as a last resort in babies.
Respiratory Support Devices
BAG & MASK VENTILATION
NEOPUFF
NASAL PRONGS
OPTIFLOW
Non-Invasive Ventilation
Non-invasive ventilation (NIV) is a well recognised and increasingly prevalent intervention in the paediatric critical care setting. In the acute setting NIV is used to provide respiratory support in a flexible manner that avoids a requirement for endotracheal intubation or tracheostomy, with the aim of avoiding the complications of invasive ventilation.
Morley, 2016.
EasyFlow nCPAP Non-Invasive Ventilation
CPAP non-invasive ventilation leaves extra air in the lungs to keep the lungs slightly inflated; this minimises the effort required for the progressive breath.
Complications of Non-invasive Ventilation
Nasal Septum Injury –
Nasal Bridge Injury –
Eye Puffiness & Hyperemia –
Abdominal Distention –
Pneumothorax –
Nasal Septum – retrieved from https://www.drugs.com/health-guide/deviated-septum.html; Nasal Bridge – retrieved from https://www.mountsinai.org/health-library/symptoms/low-nasal-bridge; Abdominal Distention – retrieved from https://adc.bmj.com/content/97/Suppl_2/A160.4.short on 27th January 2023
Ventilation
Ventilation is used as a last resort on babies.
CHILD VS ADULT AIRWAY
Unlike the adult’s airway, a baby’s airway is funnel-like, and the cricoid sits lower than in adults.
PAEDIATRIC LARYNGOSCOPY
The type of laryngoscope commonly used in case of ventilation of paediatric patients is the Miller Blade Laryngoscope with Fibre Optic.
CUFFED VS UNCUFFED ETT
we are moving towards commonly using the inflated microcuff ETT for paediatric patients, since it helps minimise the risk of aspiration
an inflated microcuff seals the trachea so as to prevent positive pressure from escaping the lower airway
an inflated microcuff also seals the upper airway so that material above the glottis cannot enter the trachea
Intubation Drugs
Babies that are intubated right after birth are NOT administered any intubation drugs during the procedure. Otherwise, babies being intubated later on are administered drugs from the following intubation drugs list:
RAPID SEQUENCE INTUBATION DRUGS (RSI)
Fentanyl – analgesic opioid
Atropine – treats symptomatic bradycardia
Suxamethonium – muscle relaxant
MAINTENANCE DRUGS
Morphine – analgesic opioid
Midazolam – benzodiazepine
Atracurium – muscle relaxant
DOSAGE CALCULATION
Rapid Sequence Intubation Drugs and Maintenance Drugs dosages are administered based on the baby’s weight according to protocol.
For antibiotic and other pharmacological drug use:
mg of drug required X volume of fluid drug is in
____________________________
mg of drug in the volume you have
NOTE: many drugs need to be administered slowly by IV infusion over half an hour.
Neonatal and Paediatric Intensive Care Nursing
WetFlag Acronym Table
Procedural Pain Relief
Measures related to the baby’s surrounding environment, preparation, and use of non-pharmacological pain relief methods can be taken for support:
warmed area
calm surrounding
parental presence
reduction of light, noise, and handling
available staff to reduce interruptions and prepare requirements beforehand
available staff to assume a parental role if parents are unavailable
promote swaddling, nesting, tucking, holding, cuddling, skin-to-skin care, breast feeding, non-nutritive sucking, clean nappy, and distraction techniques.
24% sucrose solution ampoules (Babycalmine S) can be administered as a mild analgesic for short term pain and distress in neonates and infants up to 4 months of age during minor procedures, such as bloodletting and cannulation, invasive procedures including urinary catheterisation and lumbar puncture, as well as during IM or SC immunisation and other procedures which may require pain relief.
comprehensive assessment
Comprehensive assessment in neonatal and paediatric intensive care nursing needs to be based on observing and reading clinical signs, as well as interpreting different parameters:
heart rate
blood pressure
signs of distress
abdominal distention
pressure exerted by lines
cannula observation
signs of sepsis
functioning equipment observation
NOTE: a low temperature in a baby may be a sign of sepsis; capillary refill on a newborn is checked on the sternum.
The Nurse’s Role
INFANTS:
prompt treatment may be required by premature babies suffering from respiratory difficulties
nutritional needs of premature babies and sick neonates are calculated on the baby’s weight in kg
encourage parents to stay with their infant
provide the baby with opportunities for sucking
provide toys to provide comfort and stimulate interest
provide pharmacological and non-pharmacological pain control
encourage continuation of toilet-training regime, accepting regression during hospitalisation
provide vigilance and safety within the toddler’s environment
provide short and simple explanations
reward appropriate behaviour
PARENTS:
support the parents, considering their possible anxiety and stress
encourage an active role in the care of their own child
teach parents to administer medications safely, to use any necessary equipment, to insert and/or use a feeding tube if needed
discuss with parents subjects related to home routine, safety, and how to coax a reluctant baby to feed
teach parents Basic Life Support
provide reassurance during discharge planning, since this transition may be quite difficult and scary for the parents
The Parents’ Role
Parents of young patients staying at NPICU are usually allowed to enter, excluding time in which ward rounds, handover, emergencies and admissions are being performed. The NPICU promotes:
family centered care
parents’ empowerment to prevent loss of parental role
interventions such as skin-to-skin contact and positive touch
Reference
Morley S. L. (2016). Non-invasive ventilation in paediatric critical care. Paediatric respiratory reviews, 20, 24–31. https://doi.org/10.1016/j.prrv.2016.03.001
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The first 28 days of life are the most crucial for survival. While on a global scale neonatal mortality is declining, 54% of the total deaths amongst Europe’s children under 5 occur in neonates. This sheds a light on the importance of adequate monitoring and care at the NPICU neonatal and paediatric intensive care unit.
Local causes of mortality in children under 5 years of age include:
The NPICU – Neonatal & Paediatric Intensive Care Unit
Malta’s only NPICU caters for limitless admissions of neonates and children up to 3 years of age, with the majority of these young patients being premature babies (babies born before the 37th week of gestation) and neonates (from birth to 28 days of age).
Classification of care in the NPICU is as follows:
Intensive Care – 1 or 2:1 care ratio
High Dependency Care – 1:1 care ratio
Special Care – 1:2 care ratio
Nursery – 1:4 care ratio
Apart from being allocated according to experience and training needs, NPICU nurses may need to act as transport team members, Basic Life Support educators, and link nurses.
nuchal cord (umbilical cord wrapped around baby’s neck)
ventouse (vacuum cup) / KIWI (most common type of ventouse that does not use a suction machine)
cesarean
Baby factors
CHANGES AT BIRTH:
independent breathing
foetal to neonatal circulation
metabolic adaptation to thermoregulation, glucose homeostasis, and fluid balance
POST-NATAL CHANGES:
baby’s lungs become the primary respiratory organs
lungs’ blood vessels respond to oxygen increase from vasodilation, promoting blood flow to the lungs
increase in oxygen causes heart ducts to close, leading to neonatal circulation to establish itself
NORMAL CHANGES:
during the baby’s first breaths, air replaces the fluid within the lung
THERMOREGULATORY CHANGES:
at birth, intrauterine heat reservoir and heat exchange through the placenta is lost
following birth, thermal stability is normally achieved independently, as they adapt to the new environment by the non-shivering thermogenesis process
the newborn baby should be kept warm and dry straight from delivery, since becoming cold causes the brown fat stores to become depleted, leading to neonatal hypoxia and hypoglycaemia
GLUCOSE HOMEOSTASIS CHANGES:
at birth, the baby stops obtaining glucose from the mother through the placenta, and starts to produce glucose independently, which, following birth, may cause a decrease in the baby’s blood glucose levels
normally, if kept warm and is fed appropriately within the first few hours after birth, a full term baby is able to control his/her own blood glucose levels within normal limits
FLUID BALANCE CHANGES:
at birth, fluid balance undergoes significant adaptive changes, including extra-cellular fluid contraction following delivery, where neonates may lose up to 10% of their total birth weight
respiratory distress syndrome (due to surfactant deficiency)
chronic lung disease of prematurity (caused by oxygen dependency and persistent inflammatory changes of the lungs past 28 days following birth)
apnoea of prematurity (due to immature brain stem)
NPICU Admission Guidelines
23 weeks-35 weeks or more than 42 weeks gestation
birth weight of 450g – 2kgs, SGA (small for gestational age) and LGA (large for gestational age)
respiratory issues – apnoea, cyanotic episodes, need for positive pressure ventilation, concerning respiratory distress, tachypnoea for over 1hr, perinatal asphyxia, and meconium aspiration
gastrointestinal issues – feeding problems, bile-stained vomiting, signs of obstruction
infection – sepsis suspicion, herpes, chlamydia, group B streptococcus
malformations
congenital heart defects
infants of mothers with diabetes
hypoglycaemia
seizures
surgical complications
neonatal abstinence syndrome – conditions caused when a baby withdraws from certain drugs he’s been exposed to in the womb prior to birth
hyperbilirubinaemia – higher-than-normal amount of bilirubin in the blood, causing jaundice
others as needed eg. haemoglobin, electrolytes, etc.
Central Lines
CVCs (central venous cannulas) can be used for longer than PVCs (peripheral venous cannulas). IV treatments as well as higher concentration IV fluids and TPN can be administered via a CVC with less irritation and damage to the veins.
UMBILICAL CATHETERS
A umbilical cord typically has 2 arteries and 1 vein. Catheters are placed into the blood vessel using sterile technique, followed by a confirmation x-ray to determine position.
An umbilical arterial catheter is used for:
blood sampling
ABGs
invasive blood pressure monitoring
DO NOT ADMINISTER IV FLUIDS IN AN ARTERIAL CATHETER!
An umbilical venous catheter is used for:
IV fluid administration
IV treatment
exchange transfusion
emergency access during resuscitation
PICC LINE
A PICC line – Peripherally Inserted Central Catheter – is a thread-like tube which is inserted in a small vein and threaded into a larger vein leading to the Superior Vena Cava.
when handling the baby, the nurse should be extra careful as to not pull the catheter
infusion lines should be carefully changed on alternate days using a sterile technique
NOTE: Neonatal PICC lines SHOULD NOT be used for blood sampling!
TUNNELED LINES
a tunneled catheter is a catheter inserted under the skin, exiting on the chest a.k.a. Hickman
the line is anchored in place by the Dacron cuff, helping to prevent infection
NON-TUNNELED LINES
femoral line
jugular
subclavian
brachiocephalic
INTRA-OSSEOUS LINES
TIVAD – TOTALLY IMPLANTED VENOUS ACCESS DEVICE
Totally Implanted Venous Access Devices are only used in older children
accessed and de-assessed by a certified nurse with a special needle – once needle is in place, it can be used like any other central line
PERIPHERAL ARTERIAL LINES
used for frequent blood sampling
provide accurate invasive blood pressure monitoring
high risk
CENTRAL LINE MONITORING
Central line monitoring is very important since signs and symptoms may be indicating line blockages, vein irritation, thrombus, migration, and CLABSI (central line-associated bloodstream infection). Signs and symptoms that the nurse should watch out for include:
extremity discolouration
bleeding
swelling
extravasation
dislodgement
signs of sepsis
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Burn patient rehabilitation is both a philosophy and an attitude which needs to start from the day in which the burn injury was inflicted.
Adequate nutrition is one of the most important aspects required for burn patient rehabilitation. Burn patients have increased caloric intake requirements. Lack of caloric intake leads the patient’s body to start metabolising protein, subsequently causing muscle wasting.
The Role of Nutrition in Burn Patient Rehabilitation
In patients with a burn injury, feeding should be established as early as possible, and ideally should be administered enterally. The patient’s weight should be monitored, especially since a 10% or more decrease in weight is considered to be a failure. However, it is important to note that while the catabolic state of large burn injuries result in a rapidly falling albumin level causing a decrease in dry weight, this decrease is masked due to the large fluid resuscitation volume administered in the first few days following the injury.
NOTE: patients requiring starvation for anaesthesia should be kept starved for the least time possible, starting from 6hrs pre-anaesthesia administration.
Basal Metabolic Rate – BMR
The Basal Metabolic Rate is the body’s resting rate of energy expenditure. The BMR doubles in cases where the patient has experienced more than 50% TBSA (Total Body Surface Area) burn. The larger the TBSA burned, the higher the hypercatabolism degree (excessive metabolic breakdown of complex substances including protein, within the body). The patient typically also experiences hyperglycaemia resulting as another endocrine response.
Typically, the patient’s BMR continues to increase and the core temperature resets to 1-2°C higher than normal, until the burn wound heals. During this healing process, the ambient temperature should be kept around 26-30°C to reduce the body’s energy demands.
NOTE: TBSA does not take into consideration superficial burns where only the epidermis is involved.
Nutritional Intake During Admission Stage
the patient is weighed so that dry weight measurement is established and recorded
a nasogastric tube is inserted, and feeding is started at low volume
feed volume is gradually increased if the nurse determines that the feed is actually being absorbed
Caloric requirements are calculated by a dietician based on the TBSA burned. In burn patients the Curreri formula is used to determine nutritional intake requirement:
The Curreri Formula
(25 x weight in kg) + (40 x TBSA percentage)
Enteral Feeding
studies show that patients receiving enteral feeding have a decreased mortality and morbidity rate
enteral feeding is relatively easy to establish early on, and this helps decrease caloric deficit
in patients with extensive burns obviously requiring a longer hospital stay, a PEG ornasojejunal tube is recommended, since this helps avoid repeated periods of starvation, and can also be passed at the bedside; since by using this way of feeding, nutritional intake bypasses the stomach and goes directly into the intestines, the patient would not require starvation pre-anaesthesia
PEG feeding is used less in burn patients, especially if the abdomen has suffered from a burn injury, or if the abdominal skin may be required as donor skin
Total Parenteral Nutrition TPNis only indicated if enteral feeding cannot be established, since studies have shown an increase in burn mortality with IV supplemental feeding in severely burned patients; additionally, due to an increase in burn patients’ core temperature, phlebo-fix used to hold in place a central line tends to keep coming off, thus, a central line is ideally avoided
Burn Patient Co-morbidities
A burn patient may have other primary diseases such as diabetes, high cholesterol, and obesity. Such diseases are referred to as co-morbidities. For this reason, every burn patient needs to be managed in a holistic way, where all pre-existing medical conditions, any related social circumstances, and obviously the patient’s age, are taken into consideration when drawing a burn patient rehabilitation plan.
Diabetes
diabetesaffects the healing process of the burn injury due to poor circulation leading to less oxygen perfusion
burn wounds, like any other wound, is likely to become infected in a patient with diabetes, thus, patients with diabetes are frequently checked for microbe presence by wound swabbing
careful monitoring and control of blood glucose levels in patients with diabetes promote better clinical outcomes, therefore this should be monitored right from admission stage
antibiotic administration is likely to help improve graft take as well as healing period in patients with diabetes
upon admission of a diabetic patient with a burn injury, the diabetic liaison nurse should be informed
Obesity
obesity limits burn injury outcome in various ways
typically, the force of abdominal viscera on the diaphragm limits lung tidal volumes
Age
young burn injury patients are quite resilient especially since their skin is relatively thin but the ratio of their skin surface area to blood volume is relatively high
elderly patients have very thin skin, and so, burn injuries endured by patients over 65 years of age are typically classified as full thickness burns; superficial burns in the elderly tend to progress to full thickness burns due to lack of nutrition, lack of self care, and sluggish circulation
Burn Reconstructive Procedures
Reconstructive procedures are performed following burns as well as cancer tumour removal. Plastic surgery uses the Aucher classification to classify burn reconstructive procedures according to their urgency. Burn reconstruction involves scar release or excision. Closure is done either by using a normal flap or by recruiting local skin.
Primary Intention Burn Injury Healing – done through surgery; surgery however doesn’t restore sensory functioning
Secondary Intention Burn Injury Healing – done through normal wound healing, with dressing changes as required and antibiotics to avoid infection; normal wound care without plastic surgery tends to lead to contractures that limit the patient’s functionality
An injury in which part of the body is lost eg. dog bites, human bites, woodwork injuries, butchers etc, is ideally subjected to secondary intention healing, since unintentionally closing the wound with microbes inside may lead to infection and subsequent surgical reconstruction or possibly amputation.
Skin Grafts
A skin graft is a surgical intervention in which tissue is moved from one area (donor site) to another (recipient area). The donor area can be either from the same body or from another.
FULL THICKNESS SKIN GRAFTS
include the epidermis and dermis
full thickness grafts can be harvested from only a few body sites
may be used to cover bone exposure
donor sites require direct closure or split thickness graft closure
uptake rate is higher than that by split thickness grafts since the dermal layer is involved
antibiotics are administered as prophylaxis to avoid infection of skin grafts
SPLIT THICKNESS GRAFTS
include the epidermis and less than the whole thickness of the dermis
is commonly done for acute burn wound closure
healing is done through secondary intention
uptake rate is less than full thickness skin grafts since only the epidermis is involved, and this is mashed, causing fenestrations in the graft area, and is also quite stretched
Care of Grafts
foam is usually sutured or stapled over the graft to increase pressure
foam is removed after 5 days so that the graft is reviewed
graft is covered with antibacterial dressings
alternate removal of staples from graft is carried out after 2 days
Care of Donor Site
following harvesting of the skin, the donor site is covered with an alginate dressing (kaltostat) to control bleeding and protect the wound from becoming infected through contamination
donor site is exposed after 15 days so as to minimise bleeding; DO NOT REMOVE, even if bleeding is noted – remove ONLY if the wound becomes very smelly, signalling infection
Flaps – Local and Distant
flaps refer to the transferring of tissue that contains its own blood supply since vascularity is moved along with the flap during surgery
local flaps have some continuity with the defect they cover
distant flaps are separated by distance through the use of micro-surgery
flaps need to be kept warm at all times
The difference between grafts and skin flaps is in the fact that grafts do not bring their own blood supply, however, skin flaps carry their own blood supply to the recipient area.
Care of Flaps
flaps are held in place by staples or sutures
removal of staples or sutures is done based on the surgeon’s advice
NOTE: NEVER apply pressure over the flap since this impedes circulation to the area, causing flap necrosis.
Burn Patient Rehabilitation Into Society
Burn injuries have comprehensive needs which are best treated with adequate resources. This is why a multidisciplinary team, commonly managed by a lead consultant, is involved in the burn patient rehabilitation process.
Physiotherapy
physiotherapy is focused on the anatomical and physiological factors related to patient rehabilitation, helping in preventing or treating impairments or disabilities
physiotherapy promotes exercises aimed at regaining strength, range of motion, and stretching of the scar area
physiotherapy may also include chest physio which helps during the healing process, especially in patients who were exposed to smoke inhalation
occupational therapy
occupational therapy focuses on the functional aspect of the patient’s ability to participate in the daily activities of life, providing functional training to promote improvement
occupational therapy helps prepare the patient for discharge in relation to required support and services, including necessary equipment and environmental adaptations, assessment and provision
Burn Patient Challenges Prevention
Burn patients may experience various challenges during their healing process, some of which may result in disabling and disfiguring contractures. Challenges may include:
pain
scarring
acute and/or chronic oedema
muscle wasting (caused by immobilisation and long periods of reduced functionality)
psychological pain caused by trauma and body image changes
physical, mental and social limitations when compared to pre-injury
There are things we can do or promote as nurses so as to decrease or ideally prevent such challenges. These include:
educating, motivating, and empowering the patient through promoting understanding of the healing process
positioning the patient in a way as to protect the joints, reduce pressure, immobilise, and decrease oedema
splinting to protect, immobilise, prevent contractures and regain range of movement
promoting passive, active, and active assisted exercises to prevent loss of range whilst strengthening the muscles
scar massage, silicone, and pressure garments
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A burn injury happens when the skin comes into contact with something hot, causing disruption within the skin’s cell structure, resulting in skin cell death.
NOTE: Throughout this blogpost, the various burns listed are classified into burn degrees, however, this method of classification does not indicate the injury depth, and so, focus should be on the type of burn eg. superficial burn, and the percentage of skin area affected using the Lund and Browder Chart (featured further down).
The Zone of Stasis
The Zone of Stasis is the surrounding area of the burn. It is characterised by decreased tissue perfusion. Nonetheless, the skin within this zone is potentially salvageable:
the burn injury dressing should be chosen with the aim of promoting wound moisture
burnt area should be elevated so as to minimise oedema
smoking should be avoided by the patient since it puts the patient at increased risk of poor outcomes and complications
systemic diseases eg. diabetes should be managed; blood sugar levels should be kept stable
Assessing Burn Injury Surface Area
Prior to assessing a burn injury and its depth, DO NOT apply any silver sulfadiazine or any other topical agents, since doing so gives an inaccurate indication of the wound’s depth.
Superficial Burn Injury
A superficial burn, also called a 1st degree burn, is characterised by the following features:
painful
no blisters are present
only the epidermis layer is involved
erythema (redness) present due to vasodilation
complete healing typically takes up to 7 days due to re-epithelialisation
Care of Superficial Burn
superficial burns require no dressings
patient should be advised to apply emollient cream
patient should be advised to apply sunblock and to avoid the sun
Superficial Partial Thickness Burn Injury
A superficial partial thickness burn, also called a 2nd degree burn, is characterised by the following features:
very painful
pink or red
blisters present
wet and weepy
complete healing with relatively little scarring
Care of Superficial Partial thickness Burn
if available apply Aquacel (silver dressing) in the 1st 24 hours following injury
de-roof and debride the blisters UNLESS they are located on the palms or soles of the feet due to excessive pain as well as superficial nerves, to which debridement may cause irreparable problems
assess wound depth
apply silver sulfadiazine and cover with non-adherent dressing for the first 3 days following burn injury
advise patient that a lot of exudate is expected to come out from the wound
advise patient to take regular analgesia for pain management
Deep Partial Thickness Burn Injury
A deep partial thickness burn, also called a 3rd degree burn, is characterised by the following features:
usually lacks physical sensation
red with overlying eschar
scarring expected
delayed healing potential
Care of Deep Partial thickness Burn
de-roof and debride blisters (if any) UNLESS they are located on the palms or soles of the feet due to excessive pain as well as superficial nerves, to which debridement may cause irreparable problems
assess wound depth
apply silver sulfadiazine and cover with light dry dressing
inform patient that some exudate should be expected
advise patient to take regular analgesia for pain management
Full Thickness Burn Injury
A full thickness burn, also called a 3rd or 4th degree burn, is characterised by the following features:
lacks physical sensation
white, brown, tan, or black
dry and leathery
firm non-blanche
scarring expected
no healing potential
Care of Full Thickness Burn
following diagnosis of burn wound stage, refer patient to the Burns Unit
apply aquacel
elaborate surgical debridement, reconstruction, or amputation, may be indicated, depending on the case
Thermal Burns
The WHO estimates that thermal burns account for around 6.6 million injuries and 300,000 deaths yearly, worldwide. A thermal burn can be experienced through the following:
scalding (commonly caused by hot drinks in children)
direct contact with hot materials
flash and flame burns
can be a 1st, 2nd, 3rd or 4th degree burn (most full thickness burns are classified under thermal burns)
1st, 2nd and 3rd Degree Thermal Burn – Retrieved from https://burncenters.com/burns/burn-services/thermal-burns/ on 22nd January 2023
Chemical Burns
Chemical burns can be caused by direct contact with, or fumes of a chemical, usually an alkali or a strong acidic substance. Such burns can happen within various settings, including homes, work, or during an assault.
One such commonly used chemical is hydrofluoric acid – a colourless highly corrosive solution containing hydrogen fluoride in water. It is stored in a plastic container and is commonly used in industrial chemistry, glass finishing, and cleaning. Liquid hydrofluoric acid has the potential to interfere with calcium metabolism. It can cause deep skin burns, which though initially painless, may lead to a cardiac arrest and subsequent death, whilst in gas form, it can cause immediate and permanent lung damage, as well as damage to the eyes’ corneas.
Acid Attack Victim – Retrieved from https://www.bbc.com/news/uk-40559973 on 22nd January 2023
care of a chemical burn
A chemical burn requires special care and attention so as to stop the substance from spreading within the skin. When caring for a chemical burn:
obtain information as to what caused the chemical burn
obtain information on how long the area was exposed to the chemical
remove any contaminated clothing that the patient may still be wearing
wash area to dilute or remove the substance
keep the wound under running water for 20 minutes
Smoke Inhalation
Smoke inhalation, which includes inhalation of heat, chemicals, and soot, can lead to a burn injury to the airway. To confirm smoke inhalation, it is important to assess for:
burns in mouth area
sooty sputum
voice change
difficult cough
If in doubt one should still provide oxygen therapy following intubation whilst protecting the cervical spine.
TREATMENT
Based on the inhalation severity:
patient may be intubated for minimal upper airway swelling
if soot is present in large amounts, patient’s airway may need suctioning
if the respiratory tract requires support, an aggressive approach should be taken…
chest physiotherapy
bacteriological surveillance – prophylactic antibiotic is administered
administration of The Galvenstone Protocol: inhaled H1 blockers, inhaled heparin, and nebulised acetyl cysteine
Electrical Burns
Electrical burns are caused by exposure to an electric source. They typically have both an entry and an exit site. The extent of such an injury ranges from minimal injury to severe multi-organ involvement.
An electrical burn needs to be evaluated by a medical professional despite the patient’s condition, be it stable or not.
Retrieved from https://link.springer.com/article/10.1007/s12262-012-0476-x on 22nd January 2023
Radiological Burns
Radiological burns are caused by the exposure to radiation. Whilst the most common cause of a radiation burn is through UV radiation as sunburn, patients undergoing radiation may present with radiation ulcers following radiotherapy, which unfortunately increases cancer risk and causes cell death.
Retrieved from https://www.curriculumnacional.cl/link/http:/mlrd.net/radiation-burn-5b5d.SHTML on 22nd January 2023
Burn Injury Nursing Care
A patient with burns is ideally kept in a positive-pressure room when hospitalised. Positive-pressure rooms have higher air pressure than the adjoining areas, preventing airborne pathogens from entering the room to avoid the air inside becoming contaminated. This reduces the risk of burn patients acquiring infection and causing further complications in their healing process.
Shock and Fluid management
In patients with critical burns, shock causes progressive failure of the circulation, leading to a decrease in oxygen perfusion within the vital organs. Fluid resuscitation aims to:
maintain vital organ function especially when it comes to renal function
replace fluid lost within the first 8 hours following burn infliction
Fluid Resuscitation Formula – Hartmann’s
4ml x weight x affected Total Body Surface Area (TBSA)
to be administered over the first 24 hrs
(Half of the prescribed volume should be administered over the first 8 hours from burn infliction, with the rest over the following 16 hours)
CRYSTALLOIDS VS COLLOIDS
The most commonly used resuscitation fluid for initial resuscitation is the Ringer’s Lactate (Hartmann’s) or other crystalloids. Crystalloids make up a balanced solution which helps balance electrolytes in large fluid replacements.
When compared to colloids, crystalloids have a less prominent affect of volume expansion, however colloids tend to exacerbate third space losses. In burn patients, colloids (commonly used being albumin) are added to decrease the total volume of resuscitation fluid needed, since these reduce capillary leakage. Albumin is however commonly used as a rescue approach since it increases mortality in critically ill patients. Albumin:
reduces fluid creep (fluid overload)
tends to cause haemodynamic instability – hypotension, oliguria, and increasing haematocrit
If Albumin is indicated as an adjunct to the fluid resuscitation protocol, it should replace HALF of the crystalloid amount.
URINE OUTPUT
Urine output is vital for indicating successful fluid resuscitation. A urine catheter should be inserted whenever fluid resuscitation is being performed, since in burn patients, the nurse needs to monitor:
urine output
heart rate
blood pressure
ABGs
pH (patient may experience lactic acidosis)
Expected Urine Output in Patients Undergoing Fluid Resuscitation:
Adults: 0.5ml/kg/hr
Children: 1.0ml/kg/hr
NOTE: fluid resuscitation increases oedema. Fluid formulae should only be used as guidelines, and fluid calculations need to be calculated from the time at which the burn was inflicted. Ideal fluid resuscitation should include the LEAST amount of fluid necessary to maintain tissue perfusion, maintain vital physiological functions, and return physiology to normal as soon as possible.
Retrieved from https://slideplayer.com/slide/13463859/ on 23rd January 2023
THE GASTROINTESTINAL SYSTEM OF A PATIENT WITH BURNS
In burn patients, the liver’s function forms part of the systemic response to the burn injury, excreting glucagon and inflammatory markers.
Secondary Abdominal Compartment Syndrome (SACS) is a common crystalloid resuscitation complication caused by increased intra-abdominal pressure which may cause a secondary organ infarction if ignored. Typically, a patient with SACS has reduced urinary output which may also be bloody.
To avoid SACS, the patient’s intra-abdominal pressure should be measured, either via the patient’s bladder, or by measuring the intra-vesical pressure.
cleaning the burn Injury
a new burn is considered to be sterile, thus, it is important to attempt to keep it that way
clean thoroughly with an antibacterial wash eg. betadine surgical scrub
antibiotics should not be prescribed as prophylaxis, but only if infection is noted (a temperature of up to 38.5°C is considered to be normal in patients with burn injuries)
de-roof and debride large blisters UNLESS they are located on the palms or soles of the feet due to excessive pain as well as superficial nerves, to which debridement may cause irreparable problems
debride any dead skin to promote healing
Change of Dressings
in the initial stage, dressings should be changed daily, especially since at this stage these are usually found soaked
once healing starts to progress, change of dressing should be performed every 3-5 days, however, if the wound becomes painful, smelly, or soaked at any time, it should be immediately changed
encourage sunblock use over healed areas for 6-12 months
advise patient that pruritus is a common problem following burn injury, and that advise should be sought if this becomes problematic
provide patient with support and reassurance, without any false hopes
NOTE: unhealed burns lasting 3 weeks should be referred to the Burns Unit.
Renal Failure
Renal failure in a patient with burns is usually a late septic complication, especially since within the acute stage the patient would be receiving aggressive fluid resuscitation. To avoid such complication, haemofiltration is commonly considered in large burn injuries. Renal failure signs include:
oliguria of <4o0ml per day
a decline in the GFR
a rise in Urea and Creatinine
A patient needing kidney relief may be put on the PrismaFlex System.
Patient Education on Burns First Aid Care
always aim to stop the burning process by removing the heat source and any affected clothing
if clothes catch on fire, “STOP, DROP & ROLL”
put burn wound under running water for 20 minutes following a burn injury
protect the burn by covering it with a sterile non-adhesive bandage
manage pain through analgesia eg. paracetamol
DO NOT use ice water since this causes vasoconstriction, leading to burn progression
DO NOT apply any creams or ointments to burn injuries since these may cause further complications
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Shock can be classified into 3 different types: Hypovolaemic Shock, Cardiogenic Shock, and Septic Shock. Whilst the management of shock varies based on the type of shock it is, the resulting effect of all 3 types of shock is the same – decreased tissue perfusion.
Features of a Hypovolaemic Shock
Hypovolaemic shock is the most commonly occurring type of shock, which is also easily reversible if treated in a timely manner. Features of a hypovolaemic shock include:
loss of circulating or intravascular volume
impaired tissue perfusion
inadequate delivery of oxygen and nutrients
may be caused by relative and absolute hypovolaemia, or loss of blood or other fluids
Absolute Hypovolaemia
The phrase Absolute Hypovolaemia refers to external loss of fluids from the body. Fluid loss may be that of whole blood (through trauma or major surgery), loss of plasma (through burns) and loss of other fluids such as massive diuresis (through skin loss), severe vomiting, diarrhoea, and dehydration (through diabetes insipidus – a rare condition unrelated to type 1 or 2 diabetes which causes diuresis and polydipsia, diabetic ketoacidosis, and HONK – hyperglycaemic hyperosmolar non-ketotic coma – coma resulting from very high blood glucose levels in a patient with normal ketone levels; very high blood glucose levels combined with high ketone levels may be due to ketoacidosis).
Internal Haemorrhage
Internal Haemorrhage may be caused by:
fractures
GI bleeding
organ rupture (eg. spleen, liver, and kidneys)
pregnancy complications (eg. ectopic pregnancy or post-partum haemorrhage)
Fluid Loss – from intravascular space to extravascular space – may be caused by:
burns
pleural effusion
peritonitis – inflammation of the peritoneum
pancreatitis – inflammation of the pancreas
ascites – a condition in which fluid collects in spaces within the abdomen
signs of bleeding (decreased Haematocrit & Haemoglobin)
Retrieved from https://twitter.com/misirg1/status/1382458804995035144 on 19th January 2023
Management
Identify & Treat the Underlying Cause
Restore Intravascular Volume & Blood Pressure
Redistribute Fluids to Ensure Perfusion
Prevent Shock Progression
Avoid onset of Cardiogenic Shock
stop the bleeding by applying pressure to injured site and prepare patient for surgery
administer antiemetics for severe vomiting, antidiarrhoeal agents to treat diarrhoea, insulin for dehydration caused by diabetes, and desmopressin for diabetes insipidus
establish good venous access through large peripheral lines and central venous catheters
insert a urinary catheter to monitor renal perfusion and fluid balance
monitor haemodynamic parameters and the patient’s condition, and titrate fluid administration according to patient’s needs
crystalloids are electrolyte solutions such as Isotonic (eg. normal saline or RLactate), Hypertonic (eg. 10% Dextrose) or Hypotonic (eg. 0.45% NaCl – Sodium Chloride); these address both fluid and electrolyte loss
colloids include blood and its products such as Fresh Frozen Plasma (FFP), as well as synthetic plasma expanders such as Gelafundin (a colloidal plasma volume substitute in an isotonic balanced whole electrolyte solution that can be used for prophylaxis and therapy of hypovolaemia and shock); ADVANTAGES: colloids remain in the intravascular space, restoring fluids faster and with less volume, while blood restores Hgb; DISADVANTAGES: colloids are expensive, may cause reactions, and may also leak out of damaged capillaries, causing additional problems including cardiac failure and peripheral oedema
based on the patient’s blood group and cross match, administer infusions of packed red blood cells to increase circulatory volume and oxygen carrying capacity; fresh frozen plasma, platelets, and cryo precipitate (the insoluble portion, or precipitate, that remains when the liquid portion of the plasma drains away) may also be indicated – blood products are commonly administered through a blood warmer so as to prevent or manage hypothermia
during surgical procedures such as cardiothoracic surgery, chest and abdominal trauma, and orthopaedic surgery, the patient can receive own blood through the intra-operative blood salvage machine, which collects lost blood through a filtered tube and readministers it within 4 hours; this reduces the risk of reactions and infections, however, it does carry an increased risk of haemolysis and microemboli formation during the collection and administration period
pay attention to any arising complications of fluid administration eg. allergic reactions and infection, electrolyte imbalance, dilution of haemoglobin and clotting factors, and pulmonary oedema (higher risk in older adults, and patients with chronic heart failure or renal failure); monitor patient’s urine output and fluid balance, haemodynamic monitoring, fluid responsiveness, and lung sounds
haemorrhagic stroke drug therapy may include inotropes and vasopressors (typically adrenaline or noradrenaline and dobutamine) to increase cardiac output and blood pressure for better perfusion; these however increase oxygen demands; ensure secure airway and administer oxygen if needed to treat hypoxia; antifibrinolytics such as tranexamic acid may be required to prevent the breakdown of fibrin, which is the main protein in a blood clot
Retrieved from https://www.getdoc.com/blood-type-basics-blood/ on 19th January 2023
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Shock can be classified into 3 different types: Hypovolaemic Shock, Cardiogenic Shock, and Septic Shock. Whilst the management of shock varies based on the type of shock it is, the resulting effect of all 3 types of shock is the same – decreased tissue perfusion.
Distributive Shock
impaired distribution of circulating blood volume
vasodilation
capillary leaks
Distributive Shock is sub-classified into 3 other types of shock: septic shock, anaphylactic shock and neurogenic shock. In this blogpost we will be focusing on Septic Shock.
Septic Shock
While sepsis is defined as a life-threatening organ dysfunction caused by dysregulated host response to infection, a septic shock is defined as a subset of sepsis in which underlying circulatory, cellular and metabolic abnormalities and profound enough to substantially increase the risk of mortality.
microorganism entry into the patient’s body
dysregulated host response characterised by excessive peripheral vasodilation, causing maldistribution of blood volume, over-perfused peripheral areas and under-perfused central areas
is the major cause of admission in the critical care setting
Septic Shock may originate from the community (>80% of cases) or during a stay in a healthcare facility. Common sites for origin of septic shock include:
Rapid recognition and resuscitation is crucial for survival, and so, deteriorating patients should be investigated for infection in a timely manner.
Sepsis
Septic Shock
presence of infection
adequate fluid resuscitation not enough
acute change in SOFA score of 2 points or more from baseline
vasopressors required to keep MAP at >65mmHg and Serum Lactate at >2mmol/L
Sequential Organ Failure Assessment Score (SOFA)
SOFA is a bedside tool that helps identify patients with infection at an increased risk of death or prolonged ICU stay. SOFA is considered to be positive when the patient has at least 2 of the following 3 criteria:
respiratory rate of >22 breaths/minute
altered mental state with a GCS <15
systolic blood pressure <100mmHg
Retrieved from https://www.crit.cloud/summaries–reviews/the-bat-and-the-sofa-the-3rd-consensus-definitions-for-sepsis-are-out on 20th January 2023
Multiple Organ Dysfunction Syndrome (MODS)
MODS refers to a clinical syndrome characterised by acute potentially reversible dysfunction of two or more organs or organ systems not directly involved in the primary disease process. It is the ultimate complication of Septic Shock.
Airway Support
stabilise the patient’s airway
maintain oxygen saturation >94% (unless patient has COPD)
mechanical ventilation may be required to improve oxygenation and neutralise metabolic acidosis
Identifying Source of Sepsis + Treatment
Microbiology – blood, sputum, CSF, urine, wound swab specimens should be sent immediately for Culture & Sensitivity (2 sets of blood cultures should be taken, the 2nd one being with increased sensitivity for detecting bacteraemia); IMPORTANT: take cultures BEFORE antibiotics are administered (even though broad antibiotics should be started within 1 hour)!
Radiology – x-ray and CT scan should be performed to check for signs of infection
IV Antibiotics – start broad spectrum IV antibiotics within one hour to cover likely causative agents such as resistant organisms like MRSA, VREs and Klebsiella, or endogenous infections by colonising bacteria
Adjust Antibiotic Regime – upon identification of specific pathogens
Eliminate Sepsis Source within 12 Hours – debride any infected or nectrotic tissue, drain abscesses and secretions, and remove infective invasive devices
Fluid Resuscitation
Fluids are required to counteract absolute hypovolaemia (sweating, diarrhoea, hyperventilation) and relative hypovolaemia (vasodilation and peripheral blood pooling).
start crystalloids within one hour using the fluid challenge – 30ml/kg over 3 hours, titrating according to response
if necessary, colloids may be administered to patients who had to receive large volumes of crystalloids
CAUTION: watch out for fluid and chloride overload
Inotropes and Vasopressors
If fluid administration is unsuccessful in maintaining physiological parameters and adequate perfusion (MAP should be maintained at >65mmHg), or in the case of myocardial dysfunction, inotropes and vasopressors may be required.
administer noradrenaline to revere inappropriate vasodilation, lower risk of tachycardia and arrhythmias with less adverse metabolic effects
adrenaline may also be added as an adjunct if required
dobutamine may also be added if the patient remains unstable; this may also help counteract excessive vasoconstriction, especially within the peripheries
Corticosteroid Use
corticosteriods (hydrocortisone 200mg/day) may be indicated due to their anti-inflammatory effects in patients unresponsive to fluids and vasopressors NOTE: corticosteroids should not be discontinued abruptly!
Nutrition
nutritional support is particularly important for patients with septic shock since this helps improve their immune response
in case of patients with wounds, a high protein diet is recommended since it helps speed up the healing process
maintain the patient’s blood glucose level at <10mmol/L but avoid excessive glucose control to prevent hypoglycaemia
General Support
maintain temperature control to decrease metabolic demands
provide skin care and pressure ulcer prophylactic measures
provide prophylactic therapy to prevent venous thromboembolism
prevent over-sedation
aim to prevent ventilator-acquired pneumonia and infections related to lines/catheter use
provide blood transfusions only if the patient’s Hgb is <7mmol/L, or in case of bleeding, myocardial ischaemia, and severe hypoxia
Give high-flow oxygen via non-rebreathe bag. Take blood cultures and consider source control. Give IV antibiotics according to local protocol. Start IV fluid resuscitation Hartmann’s or equivalent. Check lactate. Monitor hourly urine output consider catheterisation. within one hour….plus Critical Care support – Retrieved from https://slideplayer.com/slide/12865670/ on 20th January 2023
Retrieved from https://slideplayer.com/slide/17346484/ on 20th January 2023
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Shock can be classified into 3 different types: Hypovolaemic Shock, Cardiogenic Shock, and Septic Shock. Whilst the management of shock varies based on the type of shock it is, the resulting effect of all 3 types of shock is the same – decreased tissue perfusion.
Cardiogenic Shock
impaired ability of the heart to pump blood as it should (left or right ventricle dysfunction), causing systemic hypoperfusion and tissue hypoxia
may be caused by cardiac injury (eg. cardiac tamponade), cardiopulmonary arrest, following cardiac surgery, dysrhythmias (severe tachycardia or bradycardia), myocardial tissue necrosis following a Myocardial Infarction, or structural problems (eg. valvular damage or regurgitation, pulmonary embolus, acute myocarditis, papillary muscle rupture, intracardiac tumour, and congenital defects
compensatory mechanisms may worsen the situation…eg. reduced cardiac output due to myocardium death causes increased contractility which further increases the heart’s workload and oxygen demand; reduced blood pressure causes the release of catecholamines which leads to vasoconstriction, subsequently leading to a further increase in cardiac workload and oxygen demand
signs of pulmonary oedema eg. hypoxaemia, crackles, and frothy sputum
Management
Treat Underlying Cause to Prevent Further Damage & Preserve Healthy Myocardium
Enhance Pumping Effectiveness by Increasing Cardiac Output
Improve oxygen perfusion in the heart as well as other organs and tissues
Increase oxygen supply and reduce oxygen demand of the heart
provide oxygen therapy through supplementary oxygen or mechanical ventilation due to cardiac ischaemia and chest pain
administer morphine for analgesia and sedation, and promote rest
if patient has pulmonary oedema, administer diureticseg. furosemide or bumetanide, and oxygen whilst monitoring haemodynamic status and ABGs of the patient; diuretics reduce fluid accumulation which causes a decrease in preload – monitor for fluid and electrolyte imbalance
provide mechanical reperfusion through PCI (percutaneous coronary intervention) eg. angioplasty and coronary stents, or a coronary artery bypass graft (CABG)
providethrombolytic therapy through pharmacologic agents eg. streptokinase, urokinase, tissue plasminogen activator TPA, which dissolve clots in coronary artery BEFORE cardiogenic shock sets in; ATTENTION: watch out for bleeding!
provide drug therapy that helps improve cardiac output by increasing cardiac contractility, decreasing preload and afterload, and stabilising the heart rate
provide fluids with great caution since this increases risk of pulmonary oedema
administer inotropes (eg. dobutamine or milrinone) to improve contractility and reduce afterload, and vasopressors (eg. adrenaline or noradrenaline) to increase contractility, vasoconstriction, blood pressure, and heart rate NOTE: inotropes and vasopressors can be given in combination
administer vasodilatorseg. nitrates to reduce oxygen demands by reducing preload through venous dilation, reducing afterload by arterial dilation due to less resistance, increasing oxygen supply to the myocardium due to coronary vasodilation, but ATTENTION – vasodilators cause hypotension!
treat arrhythmias with anti-arrhythmic drugs eg. amiodarone to help increase time for ventricular filling
make use of the intra-aortic balloon pump – a long balloon attached to a large bore catheter inserted through the femoral artery to the descending aorta, with the balloon tip placed just below the aortic arch, and the bottom tip above the renal artery; the attached machine helps by inflating the balloon with helium at the start of diastole when the aortic valve closes, and rapidly deflating it at the start of ventricular systole, just before the aortic valve opens; ATTENTION to possible complications eg. dislodgement of clots, limb ischaemia / neuropathy (check pedal pulses), bleeding (check clotting time before insertion and removal), infection, balloon rupture, and improper position
if indicated, the Left Ventricular Assist Device may be used – flow pump which is placed across the aortic valve into the left ventricle; it draws blood continuously from the left ventricle to the proximal aorta; may be used prior to transplantation or long term for transplantation-ineligible patients
the VA-ECMO is a device through which deoxygenated blood is drained through the central vein; blood is then oxygenated outside of the patient’s body, before being returned through the large artery; it helps improve aortic flow and organ perfusion, however, it may increase afterload and worsen pulmonary oedema; note increased risk of acute kidney injury, severe bleeding, lower limb ischaemia, and stroke
if indicated, a patient with cardiogenic shock may undergo surgical interventions such as human heart transplantation, repair of septal, ventricular, or papillary muscle rupture, or valve repair or change
Retrieved from https://www.magonlinelibrary.com/doi/abs/10.12968/bjca.2021.0055?journalCode=bjca on 20th January 2023
Retrieved from https://www.facebook.com/jamajournal/photos/a.10158814898548341/10158814906348341/?type=3&locale=zh_HK on 19th January 2023
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Shock nursing management depends on the accurate and timely identification of shock. This can be obtained through an accurate assessment, thorough investigations, and a proper diagnosis, following which, the right treatment and requirements can be planned and provided to the patient.
Assessment
When assessing for shock, one should keep in mind that clinical changes are initially quite subtle. Still, the following aspects must be taken into account during an initial patient assessment…
patient history
level of consciousness
signs of internal or external bleeding
skin colour and/or moisture
respiratory rate and effort
heart rate and rhythm
body temperature
blood pressure
urine output
Retrieved from https://www.grepmed.com/images/4224/types-table-signs-classification-symptoms on 16th January 2023
Retrieved from https://doctorlib.info/medical/harrisons-manual-medicine/12.html on 16th January 2023
Investigations
Clinical tests should be carried out to confirm shock and identify the patient’s array of needs…
CBC – a complete blood count test measures the amount of red blood cells (which carry oxygen) and white blood cells (which fight infection); this test gives a good indication of bleeding and infection.
ABGs – an arterial blood gases test measures the acidity (pH) and the levels of oxygen and carbon dioxide in arterial blood; this test determines how well the patient’s lungs are performing gas exchange.
Lactate Level – normal blood lactate levels are 1.3 mmol/L; an increase in lactate production is usually caused by impaired tissue oxygenation whereby the lungs switch from performing aerobic to anaerobic respiration.
Cross Match – this is done in case the patient is found to be needing a blood transfusion.
Electrolytes – electrolyte imbalance can be indicative of shock in the progressive phase.
Clotting – impaired coagulation and microclots are indicative of shock in the progressive phase.
Alcohol Levels – these are tested if the patient suffered from trauma.
Cardiac Enzymes – cardiac enzymes a.k.a. cardiac biomarkers are released by the heart in the case of heart damage or stress caused by low oxygen; Troponin and creatinine phosphokinase (CPK) levels rise following a heart attack; elevated heart enzyme levels may also indicate acute coronary syndrome or ischaemia.
X-rays, CT scan of the Patient’s Chest, Abdomen and Spine – determines if there is infection, injury, and fluid loss.
Retrieved from https://oxfordmedicalsimulation.com/learning/blood-gases/normal-blood-gas-sig001us/ on 16th January 2023
Retrieved from https://veteriankey.com/blood-gas-acid-base-analysis-and-electrolyte-abnormalities/ on 16th January 2023
Diagnosis
Clinical manifestations of shock vary according to both the underlying cause and the stage it is at, varying based on the cause of shock as well as the patient’s physiological response.
Typically, a patient is considered to be in shock when the following signs are noted:
RESTORE ADEQUATE TISSUE PERFUSION – this can be achieved through ensuring adequate oxygen delivery to the cells in relation to gas exchange, cardiac output, and haemoglobin, as well as improving oxygen utilisation by the cells
PREVENT SHOCK PROGRESSION INTO FURTHER STAGES
Thus, in shock nursing management, the following steps need to be tackled as needed:
improving oxygen supply
administering fluid therapy
administering cardiovascular drugs
providing nutritional support
providing psychosocial care
1. Improving Oxygen Supply
With adequate oxygen supply we aim to:
achieve adequate gas exchange – ensure the patient has a patent airway, and improve ventilation and oxygenation by providing supplemental oxygen and mechanical ventilation if required
achieve adequate cardiac output – aim to control the patient’s heart rate, preload and afterload, and cardiac contractility through the administration and titration of fluids and cardiovascular drugs
2. Administering Fluid Therapy
Fluid therapy administration is necessary for all types of shock, though the type of fluid administered and the amount and speed of delivery varies with every patient.
Fluids help increase oxygenation since oxygenation is partly affected by circulation. Types of fluids administered include:
crystalloids – electrolyte solutions such as Isotonic (eg. normal saline or RLactate), Hypertonic (eg. 10% Dextrose) or Hypotonic (eg. 0.45% NaCl – Sodium Chloride)
colloids – types of colloids, which contain large molecules, include blood and its products such as Fresh Frozen Plasma (FFP), as well as synthetic plasma expanders such as Gelafundin (a colloidal plasma volume substitute in an isotonic balanced whole electrolyte solution that can be used for prophylaxis and therapy of hypovolaemia and shock); ADVANTAGES: colloids remain in the intravascular space, restoring fluids faster and with less volume, while blood restores Hgb; DISADVANTAGES: colloids are expensive, may cause reactions, and may also leak out of damaged capillaries, causing additional problems especially within the lungs
fluid administration Complications
Common fluid administration complications include cardiovascular overload and pulmonary oedema.
Patients with increased risk include elderly patients and patients with a history of chronic renal failure or heart failure.
To avoid fluid administration complications, the nurse should:
monitor and document urine output and fluid intake
anti-dysrhythmic agents such as Amiodarone prevent or treat abnormal heart rates and rhythms
Vasodilators
vasodilators such as nitrates cause arterial dilation by decreasing the afterload following decreased resistance to blood ejection, leading to an increase of cardiac output without increased oxygen demands
vasodilators also cause venous dilation by reducing the preload and subsequently reducing the filling pressure on the failing heart
NOTE: Vasodilators REDUCE BLOOD PRESSURE! Monitor patient at all times whilst on vasodilators!
Inotropes and Vasoconstrictors
inotropes and vasoconstrictors increase myocardial contractility leading to an increase in cardiac output
inotropes stimulate adrenergic receptors, causing similar effects to the fight or flight reaction; types of sympathomimetic agents include naturally occurring catecholamines eg. adrenaline, noradrenaline and dopamine; synthetic cathecolamines eg. dobutamine
NOTE: Vasoconstrictors INCREASE BLOOD PRESSURE!
ADRENALINE (EPINEPHRINE)
binds to beta 1 and beta 2 receptors
cause an increase in heart rate, cardiac contractility, vasodilation, and cardiac output
with an increasing rate of infusion also comes an increase in alpha receptors, which result in increased blood pressure and vascular resistance through vasoconstriction
the heart now needs to work harder and so, its oxygen demand increases too
NORADRENALINE
binds to beta 1 receptors only
does not cause an increase in heart rate
a low dose of noradrenalineincreases cardiac contractility, leading to an increase in cardiac output
higher doses tend to limit effect due to alpha stimulation which causes massive vasoconstriction
whilst this causes an increase in blood pressure, it compromises peripheral circulation and increases the workload of the heart
DOPAMINE
dopamine is the chemical precursor of noradrenaline
a low dose of dopamine stimulates dopaminergic receptors, causing renal and mesentric vasodilation, leading to a good urine output
a moderate dose of dopamine stimulates beta 1 receptors, causing an increase in cardiac contractility and cardiac output
a high dose of dopamine stimulates alpha receptors, causing massive vasoconstriction, an increase in blood pressure, and an increase in the workload of the heart
DOBUTAMINE
dobutamine causes no dopaminergic effects
dobutamine mainly stimulates beta 1 receptors, causing an increase in cardiac contractility and cardiac output; dobutamine may also stimulate beta 2 receptors, causing mild vasodilation, causing a reduction the the preload, afterload, and stress on the heart
dobutamine is helpful in treating heart failure, especially in hypotensive patients who are unable to tolerate vasodilators
dobutamine may also be used as an adjunct therapy to adrenaline or noradrenaline and dopamine to reduce vasoconstriction effect
ADMINISTRATION OF INOTROPES:
correct dilution of inotropes is of utmost importance
inotropes are administrated as infusions through electronic pumps so that consistent administration is ensured
administration of inotropes is done through a central line
careful haemodynamic monitoring is very important especially since it help in the titrating process of inotropes dosage as needed
inotropes should NOT replace fluid and electrolyte balance
Shock causes increased metabolic rates, which in return increase the patient’s energy requirements. Catecholamines (adrenaline and noradrenaline) deplete glycogen stores in 8-10 hours, after which the body starts breaking down skeletal muscle for energy. This prolongs recovery period unless it is prevented.
Typically, a patient in shock may require >3000kcal daily, however, the patient is usually unable to eat due to intubation, sedation, and anxiety. For this reason, enteral or parenteral nutrition should be initiated within 48 hours, and increased to full nutrition by day 3-7, if the patient is haemodynamically stable (excessive nutrient intake should be avoided in the early phase of critical illness).
NOTE: patients diagnosed with shock are also prone to develop pressure ulcers.
5. Providing Psychosocial Care
Psychological care should be provided throughout the whole course of hospitalisation, especially within the critical care environment. Liaise with other healthcare professionals as needed.
Whilst adopting an empathic approach, provide information and reassurance to both the patient (if conscious; if unconscious still talk to your patient as if he/she is listening, making him/her aware of what is going on in relation to care) and relatives, as this reduces anxiety. Communicate with the patient’s relatives about the patient’s condition as well as procedures being performed.
Shock Nursing Management Additional Interventions
ensure good vascular access for fluid administration, central venous pressure (CVP) monitoring, and to draw blood for investigations
insert a NGT (or OGT if patient has facial trauma) so that emesis (vomiting) and aspiration are prevented
insert a urinary catheter to monitor urine output and fluid balance accordingly
monitor the patient’s temperature and ensure maintenance of normal body temperature
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