The Central Nervous System is made up of 2 parts: the Brain and the Spinal Cord, both of which are connected to each other.
Spinal Cord Terminology
WHITE MATTER – aggregations of myelinated axons from many neurones supported by neuroglia
GREY MATTER – contains nerve cell bodies and dendrites OR bundles of unmyelinated axons and neuroglia
NERVE – a bundle of fibres located outside the CNS
TRACT – a bundle of fibres located in the CNS which may run long distances up and down the spinal cord; tracts are also found in the brain, connecting parts of the brain with each other as well as with the spinal cord; tracts are used in instances where various retractions from various sources are required to work altogether, eg. withdrawal following a burn (hands, feet, body, all working together to move away from the burn source)
NUCLEUS – a mass of nerve cell bodies and dendrites with similar functions located within the CNS
Functions of the Spinal Cord
The spinal cord supports integration of the reflexes. It conveys sensory impulses from the periphery to the brain, and conducts motor impulses from the brain to the periphery.
Reflexes, which are associated with skeletal muscle contraction and body functions such as heart rate, respiration, digestion, urination and defaecation, are fast responses to changes in both the internal and the external environments with the aim of maintaining homeostasis.
Spinal reflexes are reflexes carried out by the spinal cord only
Somatic reflexes are reflexes resulting in skeletal muscle contractions
Visceral reflexes a.k.a. Autonomic reflexes are reflexes resulting in the contraction of smooth or cardiac muscle, as well as gland secretion
The Reflex Arc
The reflex arc contains two or more neurones over which impulses are conducted from a receptor to the brain or spinal cord, and then to an effector.
The receptor initiates a nerve impulse in a sensory neurone in response to a change in the internal or external environment.
A sensory neurone acts as a passageway for an impulse from the receptor to the CNS
The centre is an area in the CNS where an incoming sensory impulse generates an outgoing motor impulse. This impulse may be inhibited, transmitted or rerouted. An association neurone may also be found in the centre, connecting a sensory neurone to a motor neurone which leads to a muscle or a gland
A motor neurone transmits impulses generated by the sensory or association neurone to the responding body organ
An effector is the organ (muscle or gland) that responds to the motor impulse through a reflex
The Stretch Reflex
The stretch reflex is important for the maintenance of the muscle tone. It helps prevent injuries from muscle overstretching, and is vital for muscle functioning during exercise. It is also useful for testing purposes during neurological examinations.
The Tendon Reflex
The tendon is the point of attachment between the neuron and the bone. The tendon reflex is a polysynaptic reflex arc in which more than two neurones are involved, therefore more than one synapse is produced. Tendon organs can detect and respond to changes in muscle tension produced by passive stretching or muscle contraction.
The Flexor Reflex
The flexor reflex a.k.a. withdrawal reflex is based on a polysynaptic reflex as in the tendon reflex. It causes withdrawal following a painful stimulus.
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Cerebrovascular Accident a.k.a. CVA is the medical term used when referring to a stroke. A Cerebrovascular Accident happens when there is an infarction (obstruction) of a part of the brain resulting from ischaemia (insufficient blood supply) or haemorrhage(blood vessel rupture). The blood vessel in which the infarct happens determines the area and the extent of the brain damage caused.
Prognosis
Between 25-35% of patients who experience a cerebrovascular accident end upwith long-lasting and quite often permanent neurologic dysfunction.
Most patients recover within the first few weeks following a stroke.
Up to 1 year following a stroke, minor improvements may occur.
Mortality following a stroke is mostly caused due to respiratory compromise, depression of the vital centres of the medulla, brain stem failure, and haemorrhage.
Ischaemic Cerebrovascular accident
Haemorrhagic Cerebrovascular Accident
Thrombotic Cerebrovascular accident
Arteriovenous Malformation (AVM)
NOTE: Blood clots can ONLY originate from the LEFT side of the heart. From there they travel down to the left ventricle and are pumped out from the Aorta,carrying oxygenated blood to the other parts within the body, including to the brain, which is where a cerebrovascular accident may happen.
Thus, blood clots can NEVER originate from Deep Vein Thrombosis since the venous system carries de-oxygenated blood back to the heart and not to other parts of the body.
Blood Circulation – Arteries vs Veins
Cerebrovascular Accident Risk Factors
HYPERTENSION– causes blood vessel damage through narrowing, rupturing or leaking; may also cause blood clots to form within the arteries which supply blood to the brain, leading to a blockage that can easily result in a cerebrovascular accident.
SMOKING – increases blood pressure, reduces oxygen in the blood, increases blood stickiness resulting in an increased risk of blood clot formation.
HYPERCHOLESTEROLEMIA– increases the risk of cardiovascular disease – a risk factor for stroke. Fat deposits within the arteries due to cholesterol may block the blood flow to the brain, leading to a reduction in oxygenated blood reaching the brain.
DIABETES MELLITUS – excessive sugar in the blood causes damage to the blood vessels, causing blood vessel stiffness and build-up of fat deposits in the arteries.
RACE – there seem to be a higher risk of a cerebrovascular accident to happen in blacks than in whites
Cerebrovascular Accident Clinical Manifestations
Feeling weak
Numbness
Visual impairment
Impaired speech
Lack of coordination
Cranial nerve abnormalities
Transient Ischaemic Attack (TIA) – “mini stroke” or “riħ ta’ puplesija” in Maltese, caused by a temporary disruption in the blood supply to part of the brain.
Cerebrovascular Accident Diagnosis
Patient history
Physical assessment
CT Scan – through a series of x-rays and a computer device, a CT Scan produces 3D imagery of soft tissues and bones. It is painless and non-invasive.
MRI – used to investigate or diagnose conditions affecting soft tissue.
Cerebral angiography – through the use of a catheter, x-ray imaging guidance along with injected contrast material allows the examination of blood vessels in the brain which can help detect vascular abnormalities.
Echocardiogram – transthoracic echocardiography can help identify causes of CVA that may require an intervention (eg. atrial abnormalities and infective endocarditis).
Cerebrovascular Accident Clinical Management
proper patient positioning for the prevention of contractures and aspiration
physical therapy
occupational therapy
speech therapy – SLP review
swallowing therapy
drugs such as Aspirin, Ticlopidine, Warfarin, Heparin, Steroids
CVA Intervention using Stent Retriever
Physical Therapy
Occupational Therapy
Speech Therapy
Swallowing therapy
Cerebrovascular Accident Complications
Complications following a cerebrovascular accident include fatigue, shoulder pain, incontinence, formation of pressure sores, urinary tract infections, depression, as well as a direct impact on the person’s job, transportation, independence and relationships.
Other serious complications include:
Brain stem damage – causes dizziness or lack of motor function; very rarely results also in paralysis, coma or death.
Hemiplegia – a.k.a. Hemiparesis (Hemi = Half); causes weakness, stiffness and lack of control in one side of the body.
Respiratory complications – atelectasis (when one or more areas within in the lung collapses) and pneumonia – infection in the lung parenchyma.
Acute respiratory distress syndrome ARDS – rapid onset of widespread inflammation within the lungs that results in respiratory failure.
Neurogenic pulmonary oedema -increased pulmonary interstitial and alveolar fluid caused by an acute central nervous system injury.
Pulmonary embolism – blood clot formation in a blood vessel (most commonly in the leg) that travels to an artery within the lungs, blocking blood flow.
Seizures – sudden uncontrolled electrical disturbance in the brain that may cause behavioural changes, movements or feelings.
Deep vein thrombosis – blood clot formation in a deep (non-superficial) vein.
Hypothalamic syndrome – a problem within the hypothalamus – the control centre for the pituitary glands and is responsible for multiple body functions; may lead to diabetes insipidus (causes frequent urination and excessive thirst), and hypothermia (loss of bodily heat resulting in lower body temperature).
Nursing Care
Avoid aspiration
Ensure adequate nutrition
Address constipation
Address self-care deficit
Address aphasia (impaired verbal communication)
Address impaired physical mobility – refer for physiotherapy review, encourage mobility exercises, make use of compression socks to avoid possible DVT, and check regarding administration of a blood thinner eg. Clexane or Heparin (depending on the type of CVA – in case of a haemorrhagic CVA do not administer anticoagulants)
Promote independence in relation to activities of daily living
Place patient belongings at reach from the affected side to avoid its neglect
If patient is incontinent, use nappies but change frequently to avoid formation of sacral pressure ulcers. Make sure skin is cleaned well (use a wet incopad to clean patient if needed) and dry thoroughly. If barrier creams are applied, use only a thin layer and make sure it is absorbed well by the skin, as moisture promotes ulcer formation
If a patient is awaiting SLP review, do not give thin fluids as this may cause aspiration. Unless NBM, try feeding with the use of thickeners whilst patient is propped up well. Keep a pulse oxymeter on the patient and monitor SPO2…if the oxygen saturation level decreases whilst patient is being fed, aspiration is to be suspected, in which case feeding should be avoided
Patient Discharge Plan
Ensure home environment is safe and altered to reflect any changes in the patient’s body condition eg. phone with large numbers and mobility requirements.
Teach safety measures such as leaving clear pathways at home, provision of adequate lighting, and Telecare service if recommended.
Teach home care methods, targeting personal hygiene, frequent turning and repositioning, transfer techniques, bowel and bladder training, adequate clothing (to promote positive self-worth feelings), catheter care, tube feeding, as well as social stimulation and emotional support.
Suggest appropriate community services such as support groups, daycare, outpatient services, rehabilitation services, caregiver support, support services, and state-funded programs.
Review
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An average adult’s brain is one of the largest organs of the human body. In brain anatomy we learn that the brain is composed of 4 main parts:
The Brainstem
The Brain Stem a.k.a. Medulla Oblongata is the primitive part of the brain. It is not related to higher intelligence, but it is important for maintaining the breathing rate, heart rate etc.
The brainstem is the part which connects the cerebrum of the brain to the spinal cord and cerebellum. The brainstem is composed of the midbrain, the pons and the medulla oblongata. It acts as a conduction pathway for motor and sensory impulses between the brain and the spinal cord. Some co-ordinations which are considered as non-vital that are also produced from the Medulla include swallowing, vomiting, coughing, sneezing and hiccuping.
Within the medulla oblongata is an area known as the Reticular Formation where there is dispersed grey matter containing white fibres (portions of the Reticular Formation are also located within the spinal cord, pons, midbrain and diencephalon). This area is responsible for consciousness and arousal.
The Reticular Formation has 3 vital reflex centres, namely the Cardiac Centre, which regulates the heartbeat and force of contraction; the Medullary Rhythmicity Area, which adjusts the basic breathing rhythm; and the Vasomotor Centre, which regulates the blood vessels’ diameter.
The Diencephalon
The Diencephalon is a rather hidden small structure within the brain which can be found just above the brainstem, right between the cerebral hemispheres. It houses the epithalamus, thalamus, subthalamus and hypothalamus.
The Thalamus consists of two oval masses made of mostly grey matterwhich is organised into Nuclei forming the lateral walls of the third ventricle. Additionally the thalamus acts as an interpretation centre for some sensory impulses, such as pain, temperature, light touch and pressure. Certain nuclei within the thalamus serve as relay stations for all sensory impulses (other than smell) to the cerebral cortex. Other nuclei are centres for synapses in the somatic motor system.
The Hypothalamus, which is partially protected by the cella turcica of the sphenoid bone, is a small portion of the diencephalon, forming the floor and part of the lateral walls of the third ventricle. Afferent pathways originating in the peripheral sense organs make way for information from the external environment in relation to sound, taste, smell and somatic sensations, to travel to the hypothalamus. Similarly, it is also associated with feelings of rage and aggression; it regulates food intake through the feeding centre and the satiety centre, and maintains the waking state and sleep patterns.
The hypothalamus is also responsible for the monitoring of water level, hormone concentrations and blood temperature. Additionally, the hypothalamus is the principal intermediary between the nervous system and the endocrine system, releasing chemicals called regulating factors following body changes, leading to the stimulation or the inhibition of the anterior pituitary gland. Two particular hormones which are produced by the hypothalamus are the Antidiuretic Hormone (ADH) and Oxytocin.
The hypothalamus controls and integrates the autonomic nervous system by stimulating smooth muscle, regulating the cardiac muscle contraction rate as well as the secretion of many glands.
The Cerebrum
The Cerebrum makes up the largest part of the brain. It is involved in reasoning, personality, emotional intelligence, sensory, and motor functions.
The Cerebrum – the front part of the brain which comprises of gray matter (peripheral cerebral cortex) and white matter within its centre. It occupies most of the cranium space and comprises of around 7/8 of the total brain weight. The cerebrum houses a number of nuclei, including the basal ganglia, the thalamus and the hypothalamus.
The basal ganglia are paired masses of grey matter found within each cerebral hemisphere, interconnected by many fibres, and also connected to the cerebral cortex, thalamus and hypothalamus.
The caudate nucleus and the putamen control large subconscious movements of the skeletal muscles, such as arm swinging whilst walking. Gross movements are also consciously controlled by the cerebral cortex.
The globus pallidus is associated with the regulation of the muscle tone required for specific body movements.
The cerebral cortex is divided into the Sensory Areas, which interpret sensory impulses; the Motor Areas, which control muscular movement; and Association Areas, which are related to emotional and intellectual processes.
The Cerebellum
The Cerebellum is involved in fine movements.
The Cerebellum – a structure located at the back of the brain which lies inferior to the cerebrum and posterior to the brainstem. It is a motor area of the brain which is concerned with certain subconscious movements in the skeletal muscles – muscles which are required for the provision of postural adjustments for balance maintenance.
Motor areas of the cerebral cortex are able to initiate muscle contraction voluntarily. During movement, sensory areas of the cortex receive impulses from the joint nerves, which point to the extent of muscle contraction and joint movement. This action is referred to as proprioception. Proprioception determines which muscles need to contract and the strength of contraction required. The cerebral cortex then generates impulses to the pons and midbrain, which then relay the impulses over the middle and superior cerebellar peduncles to the cerebellum. A very short delay then occurs to allow the coordination of muscle contractions sequence.
The Limbic System
BRAIN ANATOMY – PROTECTION
The brain is protected by 8 cranial bones and the meninges…
Cranial Bones
Meninges
The meninges are made up of 3 main layers, namely the Dura Mater (outer layer), the Arachnoid (middle layer), and the Pia Mater (inner layer). Between the Arachnoid Mater and the Pia Mater is the Subarachnoid Space, which contains Cerebrospinal Fluid (CSF) that provides protection, as well as cleans and nourishes the brain.
CSF Flow
The CSF circulates through the subarachnoid space around the brain and spinal cord as well as through the brain’s ventricles…
Brain Anatomy – Ventricles
There are 4 cavities within the brain:
2 Lateral Ventricles
Third Ventricle
Fourth Ventricle
Brain Anatomy – Blood Supply
The brain utilises approximately 20% of the entire body’s oxygen supply. The Cerebral Arterial Circle is a collection of blood vessels that supply the brain with oxygen, glucose and nutrients.
Since the brain’s capacity for carbohydrate storage is limited, continuous glucose supply is a must.
Cerebral blood flow depends on Carbon Dioxide and Oxygen supply.
Functions of the Main Parts of the Brain
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Leg ulcers can be defined as loss of skin in areas below the knee (on the leg or foot) which take longer than 6 weeks to heal.
Factors Related To Leg Ulcers
venous disease (60-80% of all leg ulcers are of venous origin) – conditions that damage the veins eg. blood clots, deep vein thrombosis, phlebitis, varicose veins, spider veins, and chronic venous insufficiency.
arterial disease (10-30% of all leg ulcers are of arterial origin) – a.k.a. artery disease is a vascular disease affecting the body’s arteries.
diabetes mellitus – metabolic diseases characterised by hyperglycaemia due to problems with insulin secretion, insulin action, or both.
rheumatoid arthritis – an autoimmune inflammatory disease in which the immune system attacks the body’s healthy cells, leading to inflammation in the affected parts, most commonly the joints.
sickle cell anaemia – red blood cell disorder, usually inherited, in which there is lack of healthy red blood cells. In normal circumstances, red blood cells are flexible and round, thus can move easily through the blood vessels. In sickle cell anaemia, red blood cells are shaped like sickles or crescent moons.
lymphoedema – a chronic condition that causes the body’s tissues to swell, most commonly affecting the arms or legs as a result of an inefficient lymphatic system.
tumors – abnormal mass of tissue resulting from excessive cell division or cells that do not die when they should.
Sustained Venous Hypertension
Sustained Venous Hypertension happens when valves are damaged, leading to increased blood pressure in the leg veins, possibly causing ulcer formation. Sustained Venous Hypertension is caused by:
Superficial Venous Incompetence – a common condition occurring due to decreased blood flow from the leg veins up to the heart. Lack of adequate blood flow results in blood pooling in the leg veins, leading to conditions such as spider veins, reticular veins and varicose veins.
Deep Venous Incompetence – a problem with the valves of the veins of the legs, blockage of the veins, or both, leading to leg ulcers, pain and swelling.
Deep Venous Obstruction– partial or complete occlusion of the lumen leading to decreased blood flow and increased blood pooling (frequently mistaken as DVT – diagnosis requires ultrasound investigation).
Previous Deep Vein Thrombosis – a medical condition resulting from blood clot formation within a deep vein.
Impaired Calf Muscle Pump Function – issues related to vein patency, valve competence, and proper calf muscle function.
Immobility – lack of ability to move freely
Joint Disease – a common wear and tear disease typically caused by repetitive motions resulting in inflammation and structural joint damage, leading to pain, redness and swelling.
Paralysis – loss of muscle function resulting from issues with the way messages are passed from the brain to the muscles. Paralysis can be complete or partial, on one or two sides of the body, in one area or widespread.
Obesity – a complex disease involving excessive amounts of body fat, possibly leading to immobility, femoral vein compression, and high abdominal pressures.
Congestive Cardiac Failure – heart disease which is caused by the cardiac muscle pumping blood in a less efficient manner than it should.
Chronic Venous Insufficiency
Rare Causes Of Leg Ulcers
Pyoderma Gangrenosum
Vasculitis
Factors Associated With Venous Ulcers VS Arterial Ulcers
VENOUS ULCERS
eczema
skin staining
ankle flare
varicose veins
oedema
leg fracture
previous deep vein thrombosis
history of pulmonary embolism
history of varicose vein surgery
ARTERIAL ULCERS
intermittent claudication
diabetes
rheumatoid arthritis
previous arterial surgery
non-palpable foot pulses
shiny hairless skin
poor capillary refill
cold bluish foot
white colourless leg
history of heart disease
history of stroke or transient ischaemic attack
NOTE: patients who complain of not being able to walk for a while without resting, or needing to get out of bed at night to sleep on an armchair sitting down due to pain most probably have arterial ulcers.
Leg Ulcers Assessment and Management
Assessing the patient accurately leads to an accurate diagnosis. This is crucial for leg ulcers healing since different medical supplies are used for different diagnosis.
Investigating a leg ulcer should start by questioning its history – how long has it been there? Is there a pedal pulse present? Absent pedal pulse may indicate arterial deficiency.
A doppler ultrasound, which works like a blood pressure pump, allows correct diagnosis of arterial disease if present.
Graduated external compression is an important factor resulting in the treatment of venous leg ulcers, since such treatment overcomes the effects of venous hypertension by reducing venous stasis and preventing oedema. Compression treatment provides external pressure that counteracts the hydrostatic pressure within the veins whilst standing. The external pressure that compression treatment provides depends on the affected limb’s size and shape, the technique used, and the used product’s characteristics.
Ideally, a compression level of 40 mmHg at the ankle area is recommended to overcome venous hypertension.
Compression therapy should NOT be used for arterial disease!!
Studies have shown that designer dressing materials have no additional effect on wound healing than the healing achieved by the use of simple low adherent dressings covered with multilayer compression bandaging. Commonly used dressings include Aquacel Ag (absorbs and controls exudate), Inadine, and silicone-impregnated dressings.
NOTE: Avoid compression bandaging bony prominences as doing so can easily lead to pressure ulcer formation.
Other Therapies & Management
Total Negative Pressure
Maggot Therapy
Schlerotherapy
Stockings – for long term management
Barriers To Leg Ulcers Healing
dry wound bed
wet / highly exuding wound
slough presence
infection
poor nutrition
anaemia / poor blood supply
venous hypertension
Leg Ulcers Patient Education
Educate the patient with leg ulcers about:
the disease
recurrence and management of leg ulcers
the importance of exercise
the effect of obesity on leg ulceration
how better nutrition promotes better wound healing
leg elevation
mobility and its relevance to leg ulcer formation
skin care, including dry skin care to prevent further skin tissue damage
available treatments
when to seek help
NOTE: Patient should be warned that while changes in relation to the abovemay reduce the probability of leg ulcers to reappear, it may still happen.
Leg Ulcers Nursing Care
Take detailed history
Assess wound thoroughly and document all findings
Make sure the patient receives a correct diagnosis
Use appropriate dressings and correct compression bandaging
In case of infection, liaise with medical professionals for possible additional treatment
Topical antibiotic treatment should be avoided especially due to the problematic antibiotic resistance frequently encountered
Consider relevant therapies in relation to the patient’s individual needs
Identify patients in need of medical review
Refer to specialist professionals if needed in a timely manner
Be aware of the patient’s psychosocial impact of the wound
Educate patient
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When talking about electrical signals in neurons we are referring to action potentials that transmit information from one neuron to another.
Neurons are said to be electrically excitable since upon sensing factors from the surrounding environment, excitability helps in providing impulses. There are 2 types of electrical signals in neurons:
GRADED POTENTIALS – these electrical signals, which happen when a stimulus causes ligand-gated or mechanically-gated channels to open or close in an excitable cell’s plasma membrane, are active only over short distances within the body. Such a graded potential is featured as a small deviation from the membrane potential, making it either more polarised (hyperpolarising graded potential) or less polarised (depolarising graded potential).
ACTION POTENTIALS – these electrical signals are active for both short and long distances within the body. During action potentials, 2 types of voltage-gated channels open and close: Na+ channels open and let Na+ rush in the cell, causing depolarisation, while K+ channels open, causing K+ to flow out, causing repolarisation.
Both graded potentials and action potentials are produced thanks to the plasma membrane’s 2 main features:
Ion Channels
Resting Membrane Potential
Impulse Generation
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The nervous system is the body’s control centre and communications network – it is the main controlling, regulatory and communicating system within the body. It is responsible for all mental activity, including thought, learning and memory.
The nervous system works in conjunction with the endocrine system to regulate and maintain homeostasis by picking up information about the external and internal environment through its receptors.
The 3 Functions of the Human Nervous System
SENSORY – senses changes within the body as well as within the outside environment
INTEGRATIVE – is able to interpret and understand changes
MOTOR – provides a responsive action to its interpretation of sensed changes through muscular contractions or glandular secretions
The 2 Principal Divisions Emerging From The Nervous System
The Central Nervous System
Consists of the brain and the spinal cord
Controls the entire nervous system
Responsible for thoughts, emotions and memories
Integrates and correlates all kinds of incoming sensory information thanks to receptors that relay the information
Triggers nerve impulses to stimulate muscle contractions and gland secretions
The Peripheral Nervous System
Made up of various nerve processes which connect the brain and spinal cord through receptors, muscles and glands
Divides into the Afferent System (nerve cells ‘afferent neurones’ that convey information from peripheral receptors to the CNS) and the Efferent System (nerve cells ‘efferent neurones’ that convey information from the CNS to muscles and glands)
The Efferent System subdivides into the Somatic Nervous System (voluntary effect by efferent neurones conducting impulses from the CNS to the skeletal muscle tissue) and the Autonomic Nervous System (involuntary effect by efferent neurones conveying impulses from the CNS to smooth muscle tissue, cardiac muscle tissue and glands)
Nervous Tissue Histology
Nervous tissue consists of 2 types of cells:
NEURONS:
Contain well developed excitability and conductivity properties that have the ability to respond to adequate stimulus by initiating an action potential that reaches to the cell’s other end, relaying the action potential to another
Responsible for the receiving and transmitting of nerve impulses such as sensing, thinking, remembering, controlling muscle activity, and regulating glandular secretions
Is made up of 3 parts, namely the CELL BODY, which contains a nucleus surrounded by cytoplasm with all organelles and nissl bodies; DENDRITES, responsible for receiving or input; and the AXON, which propagates nerve impulses towards another neuron, muscle fibre or gland cell
Neuron Types
BIPOLAR NEURON (a.k.a. Interneuron)
One main dendrite
One axon
Commonly found in the retina of the eye, the inner ear and the brain’s olfactory area
UNIPOLAR NEURON (a.k.a. Sensory Neuron)
Begins in the embryo as bipolar neurons
Dendrites extend into the periphery from the axon
Axon branch extending into the CNS ends in synaptic end bulbs
MULTIPOLAR NEURON (a.k.a. Motor Neuron)
Several dendrites
One axon
Commonly found in the brain and the spinal cord
NEUROGLIA:
Smaller in size than neurons
Constitute half the CNS volume
Do not generate or propagate action potentials
Have the ability to multiply and divide within the mature nervous system
Support, nourish and protect neurons
Maintain homeostasis in the interstitial fluid that surrounds the neurons
Nervous System Cell Types
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Pressure ulcers, also known as decubitus ulcer, decubiti, bedsores, pressure sores, pressure injuries, and pressure necrosis, are basically ulcers caused by pressure. Similarly, pressure ulcers can also develop following shearing and friction.
Intrinsic & Extrinsic Causative Factors Leading To Pressure Ulcers
Intrinsic Factors:
Age
Malnutrition
Chronic Illness
Ischaemia
Tissue Tolerance – how much the skin and its supporting structures are able to redistribute pressure
Extrinsic Factors:
Pressure over bone-prominent areas
Shearing forces eg. patient slides down the bed
Friction – rubbing of epithelial layer of the skin against another surface
Capillary Pressure
Blood pressure at the arterial end of the capillaries is around 32mmHg, dropping to 10mmHg at the venous end.
Average mean capillary pressure is around 17mmHg. External pressures exceeding this amount is set to cause capillary obstruction.
Tissues dependent on these capillaries become deprived of blood supply, and eventually, these ischaemic tissues die.
Hyperemia – pressure applied for up to 30 minutes (resolves after an hour)
Ischaemia – unrelieved pressure for up to 6 hours (may require up to 36 hours to resolve)
Necrosis – develops after 6 hours of unrelieved pressure with microvasculature collapse and thrombosis
Ulceration – presents within 2 weeks after necrosis
Pressure Sores Etiology
Avoidable Pressure Ulcers
Pressure ulcers development can be avoided if the healthcare provider follows these 4 steps:
EVALUATE the patient’s clinical condition and perform a pressure ulcer risk assessment
DEFINE & IMPLEMENT interventions based on the patient’s individual needs and goals
MONITOR & EVALUATE how the patient is responding to the interventions
REVISE interventions as / if necessary
Pressure Ulcers Risk Assessment
Bed-bound and chair-bound individuals should be considered as being at risk for pressure ulcers
Assess higher-risk individuals at admission. Keep assessing at regular intervals as well as with any change in condition.
Assess patients in acute care on admission and at least every 24 hours, increasing assessment times in case of any change in condition
Assess patients receiving long term care on admission, followed by weekly assessments for four weeks, spacing to quarterly. Increase frequency of assessment with any change in patient’s condition
Assess patients receiving community care at home on admission and at every visit
Consider all risk factors, including decreased mental status, exposure to moisture, incontinence, device-related pressure, friction and shearing, immobility and inactivity, as well as lack of proper nutrition
Based upon the noted individualised risk assessment, guide patient on related preventative measures and modify or refer to any needed multi-disciplinary team services when necessary
Document risk assessment and work on the implementation of the individualised prevention and care plan
The Braden Risk Assessment Scale
Waterlow Pressure Ulcer Prevention Assessment
Pressure Injury Staging
Pressure injury staging requires the following considerations:
history
visual observation and palpation
full body (head to toe) skin assessment – consider patient’s position
Following the above, the following is required:
clean the pressure ulcer
note the deepest anatomic type of soft tissue that has been damaged
Mucosal Membrane Pressure Injuries
Mucosal membrane pressure injury is injury on mucous membranes on which medical devices had to be used. Pressure applied to mucous membranes can cause ischaemia, which then turns into ulceration. Such injuries cannot be staged.
Mucosal membrane pressure injury examples include pressure ulcers which develop on the nasal mucosa from pressure exerted by nasal prongs, and pressure ulcers which develop on the inner lip due to pressure exerted by an endotracheal tube.
Device-Related Pressure Injuries
Device-related pressure injuries are injuries incurred following the use of medical devices applied for diagnostic or therapeutic purposes (excluding devices that come into contact with the mucosal membranes, as mentioned above). Staging of such injuries should be done using the normal staging system.
use a dressing just to cover for protection if necessary
STAGE 2:
primary non-adherent dressing / antimicrobial dressing for susceptible patients
secondary absorptive dressing based on exhudate amount
STAGE 3:
where depth of wound is minimal follow directions for stage 2 (above)
STAGE 4:
where depth is very deep with dead spaces, manage exhudate and infection, and consider antimicrobials in susceptible patients
UNSTAGEABLE:
debride if indicated
if debridement is not indicated, minimise risk of infection by using non-adherent antimicrobial dressing which is ideal for dry wounds
Diagnosis of Pressure Ulcers
Pressure ulcers are sometimes confused with wounds caused by moisture, such as the development of wounds on an incontinent person left with a soiled diaper for a long time. Proper diagnosis is of utmost importance since prevention and treatment varies between pressure ulcers and moisture associated skin damage (MASD).
Tunneling and Undermining
Effective Wound Care Process
Negative Pressure Wound Therapy
Preventing Pressure Ulcers
The Rule of 300
SSkin Care Bundle
Patient Skin Assessment
At least once daily (or as suggested further above), perform a head-to-toe skin assessment. Note in particular common sites of pressure ulcer formation, such as the sacrum, ischium, trochanters, heels, elbows, and the back of the head
Provide individualised care when it comes to bathing frequency and cleansing agents. Mild cleansing agents are preferred. Do not use hot water and do not towel-rub eccessively so as to avoid damaging the skin. Follow bathing with the use of an appropriate lotion or moisturising agent
In patients with incontinence, cleanse skin following soiling and apply a topical barrier to protect the area. Aldanex is an ideal barrier product that helps prevent, protect and promote healing. A pouching system or collection device for faeces can also be considered so as to provide further protection to the skin
Use moisturising agents for dry skin and reduce environmental risk factors such as low humidity and cold air. Do not massage bony prominences
Positioning
Encourage mobility for patients able to move
Reposition bed-bound patients at least every 2 hours; make use of lifting devices during transferring and repositioning of patients
Reposition chair/wheelchair-bound patients every 1 hour; consider positional alignment, distribution of weight, balance and stability, and pressure redistribution
Use pillows or foam wedges to protect bony prominences from direct contact with each other
Follow a written repositioning schedule – if none is available, be proactive!
Use pressure-redistributing mattresses and chair cushion surfaces for high-risk patients; DO NOT use donut-type devices and sheepskin for pressure redistribution!
Pressure-redistributing devices should also be used in the operating room for high-risk individuals
Nutrition & Hydration
Identify patient’s nutrition needs in relation to protein and caloric intake required for individualised care
In patients with caloric or nutrition deficit, consider nutritional supplementation
Discuss multivitamin and mineral needs for the patient with the physician if needed, and administer as per physician’s orders
Further Considerations
Is there enough pressure ulcer relief equipment available for high-risk patients?
Are nursing assessments carried out as per recommendation to avoid the development of pressure ulcers?
Are nurses providing patient centered care so as to avoid development of pressure ulcers and unnecessary complications in wound care?
Is enough education on the prevention of pressure ulcers to health care providers, patients and their families, and caregivers, being provided?
Kennedy Terminal Injury
A kennedy terminal injury is a pressure injury which at times tends to develop in individuals who are dying.
These types of pressure injuries start out larger and more superficial than other pressure ulcers, yet develop rapidly in size, depth and colour. In other words, a patient may have no sign of an ulcer in the morning, yet by the afternoon, a dark flat blister would have appeared. Usually, a patient exhibiting a kennedy terminal injury tends to have a life expectancy of between 8 and 24 hours.
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The skin is an organ responsible for many of the body’s reactions to the environment, such as protection, temperature control and sensory information. It provides non-verbal information on one’s condition. It also has a profound effect on the psychological well-being of the individual. But like every other organ, it needs to be well cared for to provide optimum functionality. Wound care in nursing practice requires the knowledge of various techniques used in the assessment, treatment and care of the patient with one or multiple wounds. Techniques include debridement, cleaning, bandaging, as well as liaising with the multi-disciplinary team for better and quicker treatment.
Optimum wound care requires:
Good relevant patient history taking
Detailed documentation
Identification of the patients requiring a multidisciplinary approach
Early complication detection and referral to the appropriate specialists
Patient education
Awareness on the psychosocial impact that the skin has on the individual
Wound Healing Process
A wound is the discontinuity of the skin, mucous membrane or tissue caused by physical, chemical or biological insult. Wound healing requires:
The replacement of injured tissue with new tissues
An increased consumption of energy
HAEMOSTASIS – The body aims to stop the bleeding through vasoconstriction, platelet formation, etc. In other words, haemostasis is the body’s natural physiological response for the prevention and stopping of bleeding.
REMODELLISATION – Takes up to around 2 years of healing. This is why a visibly healed wound can just open by itself, even if untouched. Some ‘simple’ dry skin can trigger a wound to re-open.
Moist Wound Healing in Wound Care
In moist occlusive and semi-occlusive environments, epithelialisation happens at twice the rate when compared to dry environments. Moist wound healing can be achieved through the use of advanced wound care dressings. However, a wet environment can be detrimental to wound care, as this may lead to maceration as well as tissue breakdown. The key to wound healing is to keep the wound bed balanced between dry and wet – find moisture balance!
NOTE: Iodine-impregnated dressings and silver dressings can be used if wound exudate is present. Alginates, which are made of seaweed extract, can absorb exudate. Aquacel AG has the ability to absorb up to 3 times more than alginates.
NOTE: Moist wound healing shouldn’t be used for necrotic digits (fingers and toes) due to ischaemia and/or neuropathy. Necrotic digits should be kept thoroughly dry. If kept wet, infection may travel up through the whole leg, leading to the amputation of not just one toe but a whole foot.
Acute VS Chronic Wounds – chronic wounds happen when things go wrong. This usually happens within the inflammatory phase of wound healing (hours to days following wound infliction).
Problem Wounds – These are wounds that don’t heal due to other local issues, such as infections, individuals on steroidal drugs, immunocompromised individuals, etc.
Local Factors Affecting Wound Healing
Wound healing can be delayed by various factors local to the wound itself. Such factors include:
local infection
necrotic tissue or foreign body presence
poor blood supply / low oxygen perfusion
venous stasis – loss of proper vein function of the legs that would normally carry blood back towards the heart
lymph stasis – lymph circulation disorder that leads to oedema
tissue tension – a state of equilibrium between tissues and cells that prevents over-action of any part
haematoma and dead space
large defect or poor opposition
recurrent trauma
x-ray irradiated area
wound location – eg. wound over joint
Complications of Wound Healing
Infection – red, swollen, painful wound with discharge, pus or bad smell
Avoidable scar
Excess healing-keloid and hypertrophic scar
Skin pigmentation
Marjolin ulcer-occurs due to scar tissue
Contractures
Incisional hernia and wound dehiscence
Wound Descriptive Terms for Wound Care
Necrotic Eschar
Necrotic Slough
Infective
Granulation
Hyper-granulation
Poor quality granulation
Epithelialisation
Maceration
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Skin care in nursing practice is very important, especially since the skin is responsible for protection, sensation, heat regulation, excretion, secretion and absorption.
Protection – from wear and tear (subcutaneous fat beneath the skin acts as a shock absorber and helps to protect the body from trauma); against infection and chemicals (microorganisms cannot breach the barrier created by intact healthy skin); against UV radiation (melanin absorbs UV light and prevents it from damaging cellular DNA);
Sensation – the skin is the body’s largest sensory organ. Its nerve receptors detect a number of different stimuli, including mechanical (eg. pressure) and thermal (heat or cold);
Heat Regulation – the hypothalamus (found within the brain), which contains the temperature regulating centre, can trigger changes within the skin in response to temperature changes;
Excretion – the skin excretes Carbon Dioxide, water, and sweat along with a number of waste products such as Sodium Chloride and Urea;
Secretion – Sebacious glands (outgrowths of hair follicles) within the dermis secrete sebum, making the skin water-resistant;
Absorption – the skin is a useful absorbent medium for medicines such as hormones and glyceryl trinitrate (for angina treatment), as well as for the application of topical medications aimed to treat skin diseases.
Skin, including intact skin, requires ongoing care. It needs to be kept clean, moisturised and free from infection, and this can be achieved through the use of emollient (moisturiser) therapy.
Moisturisers
Moisturisers come in the form of creams, lotions and ointments. The greasier they are, the better they are at rehydrating the skin.
Moisturiser Creams
Moisturiser creams are a mixture of oil and water, but they require stabilisers (chemicals) to prevent the cream from become contaminated by bacteria and fungi. Chemicals pose a risk for irritations. The upside to moisturiser creams is that they rub easily into the skin without leaving greasy traces.
NOTE: Always test moisturiser creams on a small area eg. on the patient’s back for a minimum of 48 hours – any persistent redness signals allergic reaction.
Moisturiser Lotions
Moisturiser lotions are liquid creams which tend to have a cooling effect on the skin. Whilst moisturiser lotions tend to be less effective at moisturising the skin than creams and ointments, they are considered to be a good choice for normal routine skincare.
NOTE: Moisturiser lotions contain preservatives/chemicals. Test lotions on a small area for a minimum of 48 hours – any persistent redness signals allergic reaction.
Moisturiser Ointments
Moisturiser ointments are oil-based, with the main ingredient usually being white soft paraffin, containing very little water. This makes ointments very greasy and messy. However, ointments are more effective than creams, and are ideal for very dry and inflamed skin especially when applied during night time. Ointments form a layer on the skin that prevents water loss, while providing further hydration to the skin.
NOTE: Ointments are unlikely to cause adverse reactions since preservatives are not needed as bacteria and fungi cannot grow within this medium.
Dry carefully by patting – DO NOT rub vigorously as doing so will damage delicate and dry skin, as well as aggravate itchy skin.
Apply moisturiser immediately after while skin is warm and at its most receptive state. Start from the top and work downwards using downward strokes parallel to the direction of the hair follicles’ growth…this will prevent hair follicles from becoming blocked, leading to folliculitis (inflamed or infected follicles).
Bathing
Evaporation of water from the epidermis causes skin tightening, leading to dry skin. Hospital ambience, including the hot dry conditions and high temperature and chemical use on bed sheets, increases risk for dry skin.
DO…
MOISTURISE the patient’s skin to reduce water loss (the surface film created by moisturisers help slow down water loss)
ADD BATH OIL such as Oilatum, E45 Wash, or Aqueous Cream to the water, instead of soap, to promote rehydration of the skin due to the increased oil-to-water ratio (attn. patient safety – oils make baths slippery!)
DO NOT…
Do not use soap on dry skin as soap worsens the problem since it removes the skin’s natural oils, increasing dehydration
Do not over-wash the skin as this removes natural oils and commensal (harmless) bacteria that helps in the prevention of pathogen growth
The Scalp
The scalp is prone to becoming dry. Patients with a dry scalp usually respond well to appropriate shampoos which usually contain coal tar (eg. Polytar and T-Gel). Such shampoos need to be used on alternate days.
In case of irritation, a milder form of shampoo should be used. If dry scalp persists apply coconut oil at night.
Infections
Human skin is covered in commensal (harmless) bacteria and fungi. When the balance of commensal organisms is disrupted or when the skin integrity is breached, organisms penetrate the skin’s protective surface, resulting in cutaneous infections.
Bacteria
Bacteria can multiply quickly at body temperature, reaching harmful levels very fast. MRSA (Meticillin-Resistant Staphylococcus Aureus) and C.Diff (Clostridium Difficile) are two examples of such harmful bacteria.
Skin bacterial infections are most commonly caused by Staphylococcal and Streptococcal bacteria (eg. Impetigo and Folliculitis). These are more prominent in low hygienic conditions and in hot and wet climates. Such infections can be treated with a combination of antibiotics and good hygiene. Although superficial bacterial infections may respond to topical antibiotic treatment, oral antibiotics may be required for complete treatment. Additionally, topical antibiotics may also cause allergies, thus should be used with caution. NOTE: skin bacterial infections may be avoided by maintaining good hygiene and not itching.
Fungi
Fungi are organisms that live on both living and dead hosts.
Types of Fungal Infections include:
Tinea (Ringworm) can affect the body or the scalp. It is easily spread amongst children, and is often passed on from animals.
Candidiasis (Yeast) is usually found within skin folds following instances in which the skin is left wet. Pregnant women, the immuno-compromised, individuals on a broad spectrum of antibiotics, diabetics and HIV-positive individuals are more prone to getting Candidiasis.
Treatment for superficial fungal infections (eg. Tinea and Candidiasis) respond well to topical anti-fungal treatment, which should be applied diligently for the recommended time to avoid re-infection. Candida infection beneath the nail bed requires oral anti-fungal treatment, as topical treatment is unable to penetrate effectively in this case.
NOTE: Fungal infections can be avoided through proper skin care, including extra attention to skin folds with regards to washing and drying.
Athlete’s FootCandidiasisTinea (Ringworm)Athlete’s Foot (left) retrieved from https://health.clevelandclinic.org/how-you-can-stop-foot-and-toe-fungus-in-its-tracks/ on 15th October 2021; Candidiasis (middle) retrieved from https://www.mymed.com/diseases-conditions/candida/signs-and-symptoms-of-candidiasis on 15th October 2021; and Ringworm (right) retrieved from from https://www.askdrsears.com/topics/health-concerns/skin-care/ringworm/ on 15th October 2021
Parasites
Parasites are organisms that live on or within a host such as an animal or plant, getting food from the same host. Scabies, caused by mites, burrow into the skin, resulting in severe itching.
Scabies ParasiteScabiesScabies Parasite (left) retrieved from https://www.webmd.com/skin-problems-and-treatments/ss/slideshow-pictures-of-parasites, and Scabies (right) retrieved from https://www.webmd.com/skin-problems-and-treatments/ss/slideshow-scabies-overview on 22nd October 2021
Viral Infections
Herpes Zoster (Shingles), a viral infection which is caused by the Varicella Zoster Virus (Chickenpox), is most commonly seen in individuals over 40 years of age. It causes pain which at times may be suicidal.
Herpes Simplex (causes Herpes), another viral infection, can be found in almost the whole adult population, although it may not produce visible symptoms.
Human Papilloma Virus (Warts) can affect people of all ages.
TREATMENT:
Herpes Simplex and Herpes Zoster are most commonly treated by Acyclovir, an antiviral treatment which can be used either topically or orally. Warts are usually removed with over-the-counter treatments containing salisylic acid, which basically burns away the thickened hard skin. Common warts may also be removed with Cryotherapy through the use of liquid nitrogen.
Herpes ZosterHerpes SimplexHPV Human Papilloma VirusVaricella Zoster Virus Herpes Zoster (top left) retrieved from https://www.straitstimes.com/singapore/health/5-things-to-know-about-shingles on 16th October 2021; Herpes Simplex (top right) retrieved from https://en.wikipedia.org/wiki/Herpes_simplex on 22nd October 2021; Human Papilloma Virus (bottom left) retrieved from https://www.skincarenetwork.co.uk/dermatology/men/genital-warts/ on 16th October 2021; and Varicella Zoster Virus (bottom right) retrieved from https://www.healthychildren.org/English/safety-prevention/immunizations/Pages/Chickenpox-Vaccine-What-You-Need-to-Know.aspx on 15th October 2021
Infestations
When living creatures invade the body, an infestation occurs. Such living creatures may be seen miroscopically, and include mites (Scabies: see further up) and lice.
Lice (parasites – left) retrieved from https://www.medicalnewstoday.com/articles/318001, and Lice + Nits on hair (right) retrieved from https://www.liceclinicshawaii.com/how-to-identify-head-lice/ on 22nd October 2021
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Skin lesions can be defined as a part of the skin that has an abnormal growth or appearance when compared to intact skin. Skin lesions can be classified into 4 types:
Infections
Allergies
Burns
Skin Cancer
1. Skin Lesions – Infections
Athlete’s Foot
Retrieved from https://health.clevelandclinic.org/how-you-can-stop-foot-and-toe-fungus-in-its-tracks/ on 15th October 2021
Athlete’s foot presents as itchy red peeling in the skin between the toes as a result of infection by the fungus tinea pedis. Athlete’s foot is common due to the said areas being prone to sweat or when left wet/ not thoroughly dried.
Candidiasis
Retrieved from https://www.mymed.com/diseases-conditions/candida/signs-and-symptoms-of-candidiasis on 15th October 2021
Candidiasis is a fungal infection caused by Candida (a yeast). Candida usually presents on the skin and/or within the body, in areas such as the mouth, throat, gut, vagina, as well as areas prone to sweat (eg. under the breasts) and wetness (eg. nappy rash following prolonged humid environment).
When presenting in the mouth, Candidiasis (also known as Thrush) is characterized by white discolorations in the tongue, around the mouth, and the throat. Sometimes, irritation that causes discomfort when swallowing may occur. Oral Candidiasis can at times be caused in prolonged use of oral steroid medication eg. in asthmatic patients.
When presenting within the skin, Candidiasis causes itching, irritation, chafing or broken skin.
Ringworm
Retrieved from https://www.askdrsears.com/topics/health-concerns/skin-care/ringworm/ on 15th October 2021
Ringworm, a fungal infection of the skin, can affect both humans and animals. Typically, humans acquire ringworm from strays or pets. Ringworm usually presents in areas on the skin such as on the scalp, feet, groin and beard.
Mild ringworm is usually treated successfully by antifungal topical medication (cream). However, more severe ringworm infection usually requires antifungal oral medication to be successfully treated.
Boils and Carbuncles
Boil (left) vs Carbuncles (right) – Retrieved from https://www.diagnose-me.com/symptoms-of/boils-abscesses-carbuncles.php on 15th October 2021
Boils and Carbuncles are classified as bacterial infections. They happen as a result of inflammation of the hair follicles and sebaceous glands, and quite commonly present on the dorsal neck. Usually, local antibacterial topical medications (eg. Fucidin) don’t work on boils and carbuncles – they are usually treated through oral antibiotics.
Impetigo
Retrieved from https://www.nhs.uk/conditions/impetigo/ on 15th October 2021
Impetigo is a bacterial (staphylococcus) infection of the skin, commonly found in young children. It is highly contagious – in fact, children with Impetigo are required to be kept home so as to avoid spreading of the infection. Impetigo is commonly found around the mouth and nose, and presents as pink water-filled raised lesions which turn into a yellowish crust, which eventually ruptures.
Cold Sores
Retrieved from https://www.evansondds.com/cold-sores-what-are-they-how-to-avoid-them/ on 15th October 2021
Cold sores are small fluid-filled blisters presenting around the lips and in the oral mucosa, that cause itching and a stinging sensation. They are caused by Herpes Simplex infection. Herpes Simplex is a lifelong virus that once acquired remains dormant for long periods of time until it causes an outbreak following a trigger.
Chickenpox
Retrieved from https://www.healthychildren.org/English/safety-prevention/immunizations/Pages/Chickenpox-Vaccine-What-You-Need-to-Know.aspx on 15th October 2021
Chickenpox is caused by the Varicella Zoster virus. It presents as a very itchy skin rash with blisters. The Varicella Zoster virus is a lifelong virus that once acquired stays in the body, specifically in the sensory nerve ganglia, as a dormant infection.
Shingles
Retrieved from https://www.straitstimes.com/singapore/health/5-things-to-know-about-shingles on 16th October 2021
Shingles is the reactivation of the Varicella Zoster virus (which initially causes Chickenpox). Typically, Shingles causes pain in a particular area in the body, which is later on followed by a rash, which initially appears as red spots before turning into blisters that eventually dry up and form scabs.
Warts
Retrieved from https://www.skincarenetwork.co.uk/dermatology/men/genital-warts/ on 16th October 2021
Warts are a type of skin infection resulting from the Human Papillomavirus (HPV). Warts present as rough, skin-coloured bumps on the skin which are highly contageous and can be easily spread through skin-to-skin contact. There is currently a vaccine which is offered to girls aged 12 years (ideally administered prior to 1st sexual encounter) to prevent development of the HPV.
2. Skin Lesions – Allergies
Contact Dermatitis
Retrieved from https://nationaleczema.org/eczema/types-of-eczema/contact-dermatitis/ on 16th October 2021
Contact Dermatitis is caused by the irritation or inflammation of the skin following direct contact with a substance or material that triggers an allergic reaction. It causes itching, redness as well as swelling of the skin which eventually progresses to blistering.
Psoriasis
Retrieved from https://infusionassociates.com/infusion-therapy/psoriasis/ on 16th October 2021
Psoriasis is a chronic condition whereby overproduction of skin cells occurs. It presents as reddened epidermal lesions covered by dry silvery scales, and is commonly triggered by trauma, infection, hormonal changes and stress.
3. Skin Lesions – Burns
Retrieved from https://urgentcaresouthaven.com/burn-care-at-home-the-dos-and-donts-to-keep-in-mind/ on 16th October 2021
Burns are tissue damage and cell death that result from heat, UV radiation, chemicals or electricity. Burns can be minor medical problems or life-threatening emergencies, and treatment depends on their location and severity.
Life-threatening problems happen since in burns:
the body loses fluids, causing dehydration and electrolyte imbalance, which may lead to circulatory shock;
the burned skin is only sterile for 24 hours, after which the resulting wound becomes prone to infection.
Retrieved from https://pt.slideshare.net/winreyes/burn-injury-13545329/3 on 16th October 2021
Estimating the extent of burns in percentages using the rule of nines…
Following calculation of the extent of burns in a patient, a patient is considered critical if:
>25% of the body has 2nd degree burns
>10% of the body has 3rd degree burns
3rd degree burns are present on the face, hands or feet
Retrieved from https://www.chegg.com/homework-help/human-anatomy-8th-edition-chapter-5-problem-6cr-solution-9780134243818 on 16th October 2021
4. Skin Lesions – Skin Cancer
There are 3 major types of skin cancer:
Basal Cell Carcinoma
Squamous Cell Carcinoma
Malignant Melanoma
Basal Cell Carcinoma
Retrieved from (left image) https://cbdskincancer.com.au/skin-cancer/basal-cell-carcinoma-bcc/ and (right image) https://www.skincancer.org/skin-cancer-information/basal-cell-carcinoma/bcc-warning-signs-images/ on 16th October 2021
Basal Cell Carcinoma is the least malignant but most common type of skin cancer that most often develops on areas of skin exposed to the sun. This type of cancer arises from cells within the stratum basale and presents itself as shiny dome-shaped nodules which eventually develop a central ulcer.
Squamous Cell Carcinoma
Retrieved from (left image) https://www.researchgate.net/figure/SQUAMOUS-CELL-CARCINOMA-Source-Genetic-home-Reference_fig2_326252787 and (right image) https://www.verywellhealth.com/squamous-cell-carcinoma-1068874 on 16th October 2021
Squamous Cell Carcinoma is the second most common form of skin cancer which is characterised by abnormal accelerated growth of squamous cells. Squamous Cell Carcinoma arises from cells within the stratum spinosum and presents itself as a scaly, reddened papule that gradually forms a shallow ulcer with a firm raised border.
Malignant Melanoma
Retrieved from https://www.medpagetoday.com/resource-centers/advances-hematologic-malignancies/noncutaneous-second-primary-malignancy-patients-melanoma/2864 on 16th October 2021
Malignant Melanoma, the most deadly form of skin cancer, develops from the pigment-producing cells known as melanocytes. It may develop spontaneously or from existing moles that suddenly start exhibiting changes, indicating cancer growth.
Retrieved from https://miiskin.com/melanoma/symptoms-signs/ on 16th October 2021
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